Li et al., American journal of physiology. Renal physiology 2002
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TRAF6 , in turn, activates SAPK/JNK and p38 MAPK phosphorylation, which in turn stimulates IL-8 and MCP-1 production in these cells
Mason et al., Infect Immun 2004
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Studies using Western blot analysis of wild-type and TRAF6 ( -/- ) macrophages revealed that stimulation with STAg resulted in the rapid TRAF6 dependent phosphorylation of p38 and extracellular signal related kinase, which differentially regulated the production of IL-12 ( p40 )