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HGF — IFNG

Text-mined interactions from Literome

Noguchi et al., Inflammation 1999 : In the present study, the effect of prostaglandin E2 ( PGE2 ) on intercellular adhesion molecule-1 ( ICAM-1 ) expression in interferon-gamma (IFN-gamma) stimulated human gingival fibroblasts (HGF) was investigated ... Both the agents downregulated ICAM-1 expression in IFN-gamma stimulated HGF
Nagahori et al., Am J Respir Cell Mol Biol 1999 (Lung Injury...) : Interferon-gamma upregulates the c-Met/hepatocyte growth factor receptor expression in alveolar epithelial cells
Gohda et al., Cytokine 2000 : We examined the combined effect of IFN-gamma and various HGF inducers on HGF production in human skin fibroblasts ... IFN-gamma synergistically enhanced HGF production stimulated by 8-bromo-cAMP, one of the most effective inducers of HGF : HGF secreted from cells incubated with 1 mM of 8-bromo-cAMP, 1000 U/ml of IFN-gamma and both of these was approximately 8, 1.5 and 24 times, respectively, that secreted from untreated cells ... IFN-gamma also synergistically augmented HGF production induced by interleukin-1beta and cAMP increasing agents cholera toxin, forskolin and prostaglandin E ( 2 ) ... HGF gene expression upregulated by cholera toxin, forskolin and 8-bromo-cAMP was markedly enhanced by IFN-gamma , which was detected as early as 3 h after its addition ... The synergy between HGF inducers and IFN-gamma is not common to all HGF inducers, because HGF production stimulated by epidermal growth factor and protein-kinase-C activating phorbol esters was significantly inhibited by IFN-gamma ... These results indicate that IFN-gamma synergistically stimulates cAMP induced HGF production and inhibits HGF production induced by growth factors and protein kinase C activators in human skin fibroblasts
Kuroiwa et al., J Clin Invest 2001 (Disease Models, Animal...) : HGF also markedly suppressed IFN-gamma and TNF-alpha expression in the intestine and liver and decreased the serum IL-12
Takami et al., Am J Respir Cell Mol Biol 2002 : The mitogenic effect of HGF is dependent on costimulation with serum and is completely abrogated by interferon-gamma (IFN-gamma)
Tamai et al., Infect Immun 2002 : In CD14 ( high ) HGF, IFN-gamma markedly up-regulated CD14 and MyD88 but not TLR4 protein and MD-2 mRNA expression, while in CD14 ( low ) HGF , IFN-gamma slightly increased MyD88 and scarcely affected CD14, TLR4 protein, and MD-2 mRNA levels
Armbrust et al., Liver 2002 (Drug-Induced Liver Injury) : Hepatocyte growth factor in MNP is not directly induced by interferon-alpha, interferon-gamma or tumour necrosis factor-alpha (TNF-alpha)
Matsumoto et al., Biochem Biophys Res Commun 1992 : Tumor necrosis factor-alpha and interferon-gamma but no other cytokine tested had slightly stimulatory effects on HGF production
Takami et al., Biochem Biophys Res Commun 2004 : In the presence of interferon (IFN)-gamma , however, cholera toxin- and 8-bromo-cAMP induced HGF production was not inhibited by IL-1beta
Takami et al., Biochem Biophys Res Commun 2005 (Inflammation) : Candidates of the factors are inflammatory cytokines released by polymorphonuclear and mononuclear cells infiltrating the wounded area, but HGF production in human dermal fibroblasts is only slightly induced by interleukin (IL)-1, tumor necrosis factor (TNF)-alpha or interferon (IFN)-gamma
Futamatsu et al., Circ Res 2005 (Autoimmune Diseases...) : HGF suppressed T cell proliferation and production of IFN-gamma and increased production of IL-4 and IL-10 secreted from CD4 positive T cells in vitro
Shimabukuro et al., Immunology 1992 : The present results suggest that IFN-gamma stimulated HGF would modulate the immune responses of locally infiltrated T cells in periodontal lesions
Mahanonda et al., J Immunol 2007 : HGF production of IDO in response to P. gingivalis LPS, IFN-gamma , or the two in combination inhibited T cell proliferation in MLRs
Ryan et al., Clin Exp Immunol 2007 : The proinflammatory cytokine interferon (IFN)-gamma did not ablate MSC inhibition of alloantigen-driven proliferation but up-regulated HGF and TGF-beta1
Mahanonda et al., J Dent Res 2008 : Thus, IL-17 and IFN-gamma induce different HGF responses when administered separately
Shimabukuro et al., J Periodontal Res 1996 (Periodontitis) : Stimulation of HGF with IFN gamma clearly induced HLA-DR expression and enhanced expression of intercellular adhesion molecule-1 ( ICAM-1 ) on HGF ... Although it can not be concluded from this study that HGF are incapable of effectively presenting antigenic peptides to autologous T cells bearing appropriate T cell receptors, present results suggest that HGF may be affected by locally secreted IFN gamma and that the IFN gamma stimulated HGF may play a role in regulating immune responsiveness in inflammatory periodontal lesions
Gohda et al., J Cell Physiol 1998 (Leukemia) : Induction of hepatocyte growth factor/scatter factor by interferon-gamma in human leukemia cells ... Interferon (IFN)-gamma remarkably stimulated HGF/SF production in both cell lines at concentrations of more than 0.1 or 1 IU/ml. IFN-alpha and IFN-beta were as effective as IFN-gamma in RPMI-8226 cells, but less than IFN-gamma in KG-1 cells ... HGF/SF gene expression in KG-1 cells was also up-regulated by IFN-gamma ... These results indicated that IFN-gamma is a potent inducer of HGF/SF in human leukemia cells