◀ Back to PTEN
HIF1A — PTEN
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
HIF1A
→
PTEN
(decreases, PTEN Activity)
Evidence: it was found that activation of the PI-3 kinase/ Akt pathway through enhanced growth factor signaling or inactivation of negative regulators including PTEN or TSC2 also increased HIF activity (Figure 2).53–56
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OpenBEL Selventa BEL large corpus:
HIF1A
→
PTEN
(decreases, PTEN Activity, HIF1A Activity)
Evidence: the PI3K pathway is inhibited by PTEN and mutations in PTEN enhance HIF1-activated response
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OpenBEL Selventa BEL large corpus:
HIF1A
→
PTEN
(decreases, PTEN Activity, HIF1A Activity)
Evidence: mutations resulting in loss of function of the tumor suppressor PTEN result in increased activation of HIF1 and increased VEGF transcription
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OpenBEL Selventa BEL large corpus:
HIF1A
→
PTEN
(decreases, HIF1A Activity)
Evidence: increases protein - ligands of other receptors (thrombin, angiotensin), RAS expression, small G-protein RAC1, PTEN inhibition, diacyl glycerol kinase
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OpenBEL Selventa BEL large corpus:
HIF1A
→
PTEN
(decreases, HIF1A Activity)
Evidence: PTEN loss of function and EGFR gain of function are commonly observed in primary GBM, and are known to increase HIF-1a levels48,49. GBMs are highly vascularized tumours that are characterized by areas of necrosis surrounded by PSEUDOPALISADING CELLS that express high levels of HIF-1a protein and VEGF mRNA.
Text-mined interactions from Literome
Laughner et al., Mol Cell Biol 2001
(Breast Neoplasms) :
Increased phosphatidylinositol 3-kinase (PI3K) and AKT or decreased
PTEN activity in prostate cancer cells also
increases HIF-1alpha expression by an undefined mechanism
Bárdos et al., Mol Cell Biol 2004
:
We found that growth factor stimulation, overexpression of Akt/PKB, or loss of
PTEN resulted in enhanced expression of both
HIF-1alpha and HDM2
Phillips et al., J Biol Chem 2005
(Anoxia...) :
A molecular analysis of these events indicated that augmented CXCR4 expression was regulated by the phosphatidylinositol
3-kinase/PTEN/AKT/mammalian target of rapamycin signal transduction pathway,
activation of hypoxia inducible factor
(HIF) 1alpha , and ultimately HIF-1 dependent transcription of the CXCR4 gene
Fang et al., Cell Signal 2007
(Neovascularization, Pathologic...) :
Immunohistochemical staining indicated that
PTEN expression
suppressed HIF-1alpha , VEGF and PCNA expression in the tumor xenographs
Emerling et al., Proc Natl Acad Sci U S A 2008
:
PTEN and FOXO3a
regulate the transactivation domain of
HIF-1alpha
Mahimainathan et al., J Biol Chem 2009
(Angiomyolipoma...) :
Interestingly, increased
HIF1alpha activity present in Tsc2 null cells is
required for
PTEN transcription and protein expression