Gene interactions and pathways from curated databases and text-mining

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HIF1A — PTEN

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: HIF1A → PTEN (decreases, PTEN Activity)
    Evidence: it was found that activation of the PI-3 kinase/ Akt pathway through enhanced growth factor signaling or inactivation of negative regulators including PTEN or TSC2 also increased HIF activity (Figure 2).53–56
  • OpenBEL Selventa BEL large corpus: HIF1A → PTEN (decreases, PTEN Activity, HIF1A Activity)
    Evidence: the PI3K pathway is inhibited by PTEN and mutations in PTEN enhance HIF1-activated response
  • OpenBEL Selventa BEL large corpus: HIF1A → PTEN (decreases, PTEN Activity, HIF1A Activity)
    Evidence: mutations resulting in loss of function of the tumor suppressor PTEN result in increased activation of HIF1 and increased VEGF transcription
  • OpenBEL Selventa BEL large corpus: HIF1A → PTEN (decreases, HIF1A Activity)
    Evidence: increases protein - ligands of other receptors (thrombin, angiotensin), RAS expression, small G-protein RAC1, PTEN inhibition, diacyl glycerol kinase
  • OpenBEL Selventa BEL large corpus: HIF1A → PTEN (decreases, HIF1A Activity)
    Evidence: PTEN loss of function and EGFR gain of function are commonly observed in primary GBM, and are known to increase HIF-1a levels48,49. GBMs are highly vascularized tumours that are characterized by areas of necrosis surrounded by PSEUDOPALISADING CELLS that express high levels of HIF-1a protein and VEGF mRNA.

Text-mined interactions from Literome

Laughner et al., Mol Cell Biol 2001 (Breast Neoplasms) : Increased phosphatidylinositol 3-kinase (PI3K) and AKT or decreased PTEN activity in prostate cancer cells also increases HIF-1alpha expression by an undefined mechanism
Bárdos et al., Mol Cell Biol 2004 : We found that growth factor stimulation, overexpression of Akt/PKB, or loss of PTEN resulted in enhanced expression of both HIF-1alpha and HDM2
Phillips et al., J Biol Chem 2005 (Anoxia...) : A molecular analysis of these events indicated that augmented CXCR4 expression was regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signal transduction pathway, activation of hypoxia inducible factor (HIF) 1alpha , and ultimately HIF-1 dependent transcription of the CXCR4 gene
Fang et al., Cell Signal 2007 (Neovascularization, Pathologic...) : Immunohistochemical staining indicated that PTEN expression suppressed HIF-1alpha , VEGF and PCNA expression in the tumor xenographs
Emerling et al., Proc Natl Acad Sci U S A 2008 : PTEN and FOXO3a regulate the transactivation domain of HIF-1alpha
Mahimainathan et al., J Biol Chem 2009 (Angiomyolipoma...) : Interestingly, increased HIF1alpha activity present in Tsc2 null cells is required for PTEN transcription and protein expression