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HPD — IFNG

Text-mined interactions from Literome

Othieno et al., Infect Immun 1999 : Suppression of PPD induced IFN-gamma in PBMC containing both rTGF-beta1 ( 1 ng/ml ) and rIL-10 ( 100 pg/ml ) was 1.5-fold higher ( P < 0.05 ) than cultures containing TGF-beta1 alone and 5.7-fold higher ( P < 0.004 ) than cultures containing IL-10 alone ... Also, neutralization of endogenous TGF-beta1 and IL-10 together enhanced PPD induced IFN-gamma in PBMC in a synergistic manner
Hirsch et al., J Infect Dis 1999 (HIV Infections...) : At the time of diagnosis, purified protein derivative (PPD) stimulated production of interferon (IFN)-gamma by peripheral blood mononuclear cells from TB patients was depressed, compared with that of healthy control subjects, whereas levels of transforming growth factor ( TGF ) -beta and interleukin (IL)-10 were increased
Black et al., J Infect Dis 2001 (Mycobacterium Infections...) : The BCG-attributable increase in IFN-gamma response to M. tuberculosis PPD was greater for individuals with low initial responsiveness to MAIS antigens than for those with high initial responsiveness
Wood et al., Tuberculosis (Edinb) 2001 (Tuberculosis, Bovine) : TB infection is indicated by a predominant IFN- gamma response to bovine PPD
Black et al., Int J Tuberc Lung Dis 2001 (Hypersensitivity, Delayed...) : The 6 day IFN-gamma response to PPD correlates well with Mantoux skin test induration
Black et al., Lancet 2002 (Tuberculosis) : 483 adolescents and young adults in Malawi and 180 adolescents in the UK were tested for interferon-gamma (IFN-gamma) response to M tuberculosis purified protein derivative (PPD) in a whole blood assay, and for delayed type hypersensitivity ( DTH ) skin test response to tuberculin PPD, before and 1 year after receiving BCG ( Glaxo 1077 ) vaccination or placebo or no vaccine
Barth et al., J Neuroimmunol 2002 (Multiple Sclerosis, Chronic Progressive...) : Furthermore, the frequency of a type 0 profile ( simultaneous PPD induced IFN-gamma and TT-induced IL-5 production ) was fourfold higher in rr than in the rp patients ( 43 % vs. 10 %, p < 0.05 )
Rajavelu et al., Clin Diagn Lab Immunol 2003 (Tuberculosis) : The standard PPD and heat killed H37Rv antigens induced the maximum levels of T-cell proliferation and IFN-gamma secretion but low levels of IL-12
Garcia et al., Comp Med 2004 (Monkey Diseases...) : Lastly, the IFNgamma response to bovine PPD was significantly lower in infected cynomolgus macaques
Green et al., Clin Exp Immunol 2004 : We also demonstrate that a substantial proportion of the cells that produce IFN gamma directly ex vivo in response to PPD are gamma delta T cells and that gamma delta T cell activation requires contact with cells of human origin
Gormley et al., Vet Immunol Immunopathol 2004 (Tuberculosis, Bovine) : No significant differences were measured in the IFN-gamma responses of the reactor animals to PPD-bovine and PPD-avian for up to 65 days
Elias et al., Trans R Soc Trop Med Hyg 2005 (Tuberculosis) : PPD induced in vitro interferon gamma production is not a reliable correlate of protection against Mycobacterium tuberculosis
Winkler et al., Microbes Infect 2005 (Tuberculosis, Pulmonary) : Higher levels of PPD induced IFN-gamma in the supernatants from TB patients than from controls were found, which correlated with its intracellular expression
Buddle et al., N Z Vet J 1994 : However, from the first test after calving, the interferon-gamma responses of peripheral blood cultures to bovine PPD were low compared with the responses prior to calving
Buddle et al., Vet Immunol Immunopathol 2005 (Tuberculosis, Bovine) : This protection was associated with strong whole blood IFN-gamma responses to bovine PPD 2-4 weeks after vaccination, but within the BCG vaccinated groups, these responses were not correlated with protection
Martins et al., Tuberculosis (Edinb) 2007 : PPD stimulated peripheral leukocytes expressing CD4, CD69, cutaneous lymphocyte associated antigen ( CLA ) and intracellular IFN-gamma were enumerated in whole blood and compared with the size of in vivo PPD induced induration and IFN-gamma production levels as measured by ELISA in supernatants of PPD stimulated peripheral blood mononuclear cells
McIlleron et al., Tuberculosis (Edinb) 2007 (Tuberculosis, Pulmonary) : Drug concentrations were not associated with outcome although rifampin exposure correlated with IFN-gamma response to PPD ( p=0.0132 )
Fan et al., Scand J Immunol 2007 (Tuberculosis) : Three weeks after the last immunization, antigen-specific interferon (IFN)-gamma secreted upon stimulation with BCG-PPD or ESAT-6 protein by splenocytes of the different groups was determined by an ELISA
Diness et al., Am J Clin Nutr 2007 (Hypersensitivity, Delayed) : The ex vivo interferon-gamma response to PPD was increased by VAS ( means ratio : 1.40 ; 95 % CI : 1.03, 1.91 )
Winek et al., J Physiol Pharmacol 2008 (Tuberculosis, Pulmonary) : PPD induced IFNgamma formation was higher in TB patients than in controls
Lalor et al., J Infect Dis 2009 : We hypothesized that Mtb PPD induced IFN-gamma after BCG vaccination would be similar in infants from these 2 countries
Bezos et al., Vet Immunol Immunopathol 2010 (Goat Diseases...) : At necropsy, a positive correlation between pathology score and bovine PPD specific IFN-gamma response was found
Elliott et al., J Infect Dis 2009 (HIV Infections...) : Greater increases in interferon gamma (IFN-gamma) and skin test responses to PPD were seen at week 24 and 12 in participants with TB-IRIS ( P < or = .04 ), respectively
Dauby et al., PLoS Negl Trop Dis 2009 (Chagas Disease...) : M+B- infants produced more IFN-gamma in response to PPD than the other groups
Debebe et al., J Immunoassay Immunochem 2010 : The mean IFN-gamma response to bovine purified protein derivative, PPD in vaccinated group ( Mean +/- SEM, 0.541 +/- 0.216 ) was greater than the mean IFN-gamma response to bovine PPD in non vaccinated group ( Mean +/- SEM, 0.253 +/- 0.101 )
McFarland et al., Tuberculosis (Edinb) 2010 (Disease Models, Animal...) : Prior BCG vaccination significantly reduced lung and spleen bacterial loads by 1-1.5log CFU and upregulated PPD induced proliferation and production of IFNgamma in lymphocyte cultures
Tsumura et al., Lab Anim Sci 1989 : The in vivo IFN-alpha/beta production in NOD mice induced by NDV was also very similar to that in ICR mice, whereas the in vivo IFN-gamma production in the BCG sensitized NOD mice, which was induced by purified protein derivative (PPD) , was greater than that in the ICR mice
Onwubalili et al., Clin Exp Immunol 1985 (Tuberculosis, Pulmonary) : In all nine patients effective chemotherapy restored cutaneous reactivity, PBMC proliferative responses, neutrophil counts and IFN-alpha responses to virus by 6 months, and also IFN-gamma responses to PPD in one patient re-tested
Huygen et al., Cell Immunol 1983 (Splenomegaly) : Three different mouse strains -- BALB/c, C57BL/6J, and CBA/Ca -- were compared for their production of viral interferon upon Newcastle disease virus ( NDV ) inoculation and of interferon gamma upon antigenic stimulation with PPD following BCG sensitization
Hayashi et al., Microbiol Immunol 1981 : The interferon induced by SSM in both groups of mice shared certain physicochemical properties with the immune interferon induced by PPD in BCG sensitized mice
Link et al., J Neuroimmunol 1995 (Inflammation...) : Femtogram concentrations of rTGF-beta 1 suppressed MBP-, PLP- and PPD induced upregulation of IFN-gamma , IL-4, IL-6, tumor necrosis factor-alpha (TNF-alpha), TNF-beta and perforin in MS, and acetylcholine receptor ( AChR ) -induced augmentation of these pro-inflammatory cytokines in MG, but had no effects on autoantigen- or PPD induced expression of IL-10 or TGF-beta itself
Wood et al., Vet Microbiol 1994 (Tuberculosis, Bovine) : The problem of false positive reactions, due to the cross-reactive nature of the antigen preparations used, can largely be overcome by using a comparative assay in which an animal 's IFN-gamma response to bovine PPD and avian PPD are compared
Shinde et al., Int J Lepr Other Mycobact Dis 1993 (Leprosy...) : The tuberculoid leprosy patients showed increased lymphocyte proliferation and IFN-gamma production in response to stimulation with ICRC, M. leprae, and PPD antigens compared to other groups of LL patients and healthy donors
Hirsch et al., Proc Natl Acad Sci U S A 1996 (Tuberculosis, Pulmonary) : Production of interferon gamma (IFN-gamma) in response to PPD also was depressed by 78 %
Sugiyama et al., Acta Otolaryngol 1977 : Tonsillar lymphocytes produced classical interferon ( Type I ) in response to NDV infection and produced immune interferon ( Type II ) in response to PHA, PPD or histo-incompatible antigens
Mahanty et al., Infect Immun 1997 (Elephantiasis, Filarial) : As expected, BMA stimulated little or no gamma interferon ( IFN-gamma ) secretion in MF individuals, whereas PPD stimulated IFN-gamma in all but one
Ng et al., Vet Immunol Immunopathol 1997 (Tuberculosis, Bovine) : At 7 and 20 weeks after inoculation, bovine PPD induced IFN-gamma and IL-2 mRNA expression was detected in all animals with tuberculous lesions and in a proportion of the M. bovis inoculated animals with no lesions
Kemp et al., Scand J Immunol 1997 : It was found that IFN-gamma was produced in response to both PPD and Leishmania stimulant by T cells in the cultures