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HSF1 — PRKACB

Text-mined interactions from Literome

Ferguson et al., Genetics 2005 : Previous studies had proposed that the stress response transcription factors Msn2p/4p, but not Hsf1p , are repressed by PKA
Melling et al., J Mol Cell Cardiol 2006 (MAP Kinase Signaling System) : Recently, we reported that administration of a protein kinase A (PKA) inhibitor suppressed exercise induced hsp70 gene expression, suggesting a role for PKA in the regulation of HSF1 activation in vivo ... While the mechanism by which PKA regulates HSF1 is unclear, studies in vitro have reported that HSF1 is phosphorylated on two serine residues by mitogen activated protein kinases ( MAPKs ) ; ERK1/2 ( ser307 ) and JNK/SAPK ( ser363 ) ... Given that ERK1/2 has been shown to be a negative regulator of HSF1 in vitro, these results suggest a role for ERK1/2 in the PKA mediated regulation of HSF1 activation following exercise
Murshid et al., PloS one 2010 : These findings of PKA regulation of HSF1 through S320 phosphorylation add to our knowledge of the signaling networks converging on this factor and may contribute to elucidating its complex roles in the stress response and understanding HSF1 dysregulation in disease