Gene interactions and pathways from curated databases and text-mining

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CDKN1A — IFI27

Text-mined interactions from Literome

Chang et al., Cancer Lett 1999 (Lung Neoplasms) : Moreover, mimosine induced p21CIP1 expression in H226 and H358 cells, while it activated p27KIP1 expression in H322 cells
Sasaki et al., Brain Res Mol Brain Res 2000 : In a mutant P19 cell line, RAC65, treatment with ATRA induced neither p27 accumulation nor neuronal differentiation, but p21 mRNA expression increased markedly
Wartenberg et al., Biochim Biophys Acta 2002 (Prostatic Neoplasms) : Staurosporine induced upregulation of p21 ( WAF-1 ) whereas p27 ( Kip1 ) remained unaltered
Pozo-Guisado et al., Biochem Pharmacol 2002 (Breast Neoplasms) : Simultaneously, p21 expression was markedly induced in presence of high levels of p27 and p53
Jackson et al., Oncogene 2002 (Cell Transformation, Neoplastic...) : Collectively, our data suggest that p21 ( Cip1 ) suppresses tumor formation elicited by multiple agents and that p21 ( Cip1 ) and p27 ( Kip1 ) suppress tumor formation in different ways
Kim et al., Angiogenesis 2005 : In Western blot analysis, bFGF induced cytoplasmic translocation of p21 ( Waf1/Cip1 ) and p27 ( Kip1 ) and phosphorylation of p27 ( Kip1 ) but rk-2 treatment inhibited translocation of p21 ( Waf1/Cip1 ) and p27 ( Kip1 ) from nucleus to cytoplasm and phosphorylation of p27 ( Kip1 )
He et al., Br J Cancer 2006 : Moreover, DAP induced p21 promoted the selective increase of p27 in the CDK2 complex, but not in CDK4 complex, and this selective increase contributed to inhibition of the CDK2 kinase activity