◀ Back to STAT1
IFNA14 — STAT1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
IFNA14
→
STAT1
(indirect_complex)
You et al., Mol Cell Biol 1999, Mowen et al., Mol Cell Biol 2000, Xu et al., Frontiers in bioscience : a journal and virtual library 2008, Müller et al., Nature 1993
-
Reactome Reaction:
IFNA14
→
STAT1
(reaction)
Mowen et al., Mol Cell Biol 2000, Wesoly et al., Acta biochimica Polonica 2007, Shuai et al., Cell 1994, Müller et al., Nature 1993, Li et al., J Biol Chem 1996
Text-mined interactions from Literome
Ito et al., Blood 1999
:
Interleukin-10 inhibits expression of both
interferon alpha- and interferon gamma-
induced genes by suppressing tyrosine phosphorylation of
STAT1
Duong et al., Gastroenterology 2004
(Carcinoma, Hepatocellular...) :
Increased expression levels of Protein Phosphatase 2A were found in liver extracts from HCV transgenic mice and in liver biopsies of patients with chronic hepatitis C. Overexpression of PP2Ac in Huh7 cells resulted in hypomethylation of STAT1, increased binding to PIAS1, and reduced
interferon-alpha induced DNA binding of
STAT1
Zhang et al., Exp Eye Res 2005
:
Retinas from embryonic and neonatal stages showed that STAT3 but not
STAT1 was activated in
response to ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), fibroblast growth factor-1 (FGF1), fibroblast growth factor-2 (FGF2), epidermal growth factor (EGF),
interferon-alpha ( IFN-alpha ) and interferon-gamma (IFN-gamma) in distinct patterns
Critchley-Thorne et al., PLoS Med 2007
(Melanoma...) :
The median percentage of lymphocytes that phosphorylate
STAT1 in
response to
interferon-alpha was significantly reduced ( Delta = 16.8 % ; 95 % confidence interval, 0.98 % to 33.35 % ) in melanoma patients ( n = 9 ) compared to healthy controls ( n = 9 ) in Phosflow analysis
Wang et al., Nat Immunol 2008
:
CaMK inhibition suppressed
STAT1 mediated
interferon-alpha signaling in a mouse model of systemic lupus erythematosus
Lesinski et al., Cancer Immunol Immunother 2009
(Melanoma) :
Bortezomib pre-treatment prolongs
interferon-alpha induced
STAT1 phosphorylation in melanoma cells
Stancato et al., J Biol Chem 1996
:
Our data suggest that
interferon-alpha /beta induced tyrosine phosphorylation
increases the stability of a preexisting, latent,
STAT1-STAT2 signaling complex
Yan et al., J Biol Chem 1998
:
This same fragment inhibits
interferon-alpha dependent tyrosine phosphorylation of TYK2,
STAT1 , and STAT2