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CDKN1A — IFNG

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CDKN1A → IFNG (increases)
  Evidence: p53 and p21 protein levels were increased and pRb protein level was decreased in IFN-g-treated cells.

Text-mined interactions from Literome

Xaus et al., Immunity 1999 : Interferon gamma induces the expression of p21waf-1 and arrests macrophage cell cycle, preventing induction of apoptosis ... Inhibition of p21Waf1 with antisense oligonucleotides or using KO mice shows that the induction of p21Waf1 by IFN gamma mediates this protection
Hobeika et al., J Interferon Cytokine Res 1999 (Colonic Neoplasms) : IFN-gamma induction of p21 ( WAF1 ) is required for cell cycle inhibition and suppression of apoptosis
Kominsky et al., J Interferon Cytokine Res 2000 (Brain Neoplasms...) : The cooperative effect of ACV and IFN-gamma against the glioblastomas appears to be due to direct inhibition of DNA synthesis by ACV in the S phase of the cell cycle and induction by IFN-gamma of the tumor suppressor gene p21wAF1/CIP1 , which in turn acts at the level of proliferating cell nuclear antigen ( PCNA ) and cyclin E/cyclin dependent kinase 2 (Cdk2) binding and inhibition of function
McCullough et al., Int J Exp Pathol 2006 : We show that the hepatocyte response to IFNgamma is modulated by external survival factors and that this survival signalling requires p21 ( waf-1 )
Chen et al., Biochem Pharmacol 2010 : Furthermore, SPI-112Me enhanced interferon-gamma (IFN-gamma) stimulated STAT1 tyrosine phosphorylation, ISRE-luciferase reporter activity, p21 expression, and the anti-proliferative effect
Oya et al., Int J Oncol 1997 : At 10 ( 3 ) IU/ml, IFN-gamma inhibited p21 ( WAF1 ), increased the expression of STAT1 alpha, and sustained the elevated STAT1 alpha for up to 96 h
Kano et al., J Biochem 1997 : Northern blot analysis demonstrated that IFN-gamma enhanced p53 mRNA expression as well as p21 ( WAF1/Cip1/Sdi1 ) mRNA expression, which is mediated by the increased expression of the p53 protein
Mandal et al., Oncogene 1998 : In addition, we also show that IFN-gamma induces expression of CDK-inhibitors p21WAF1 and p27Kip1 and inhibited the H-1 kinase activity associated with CDK-2 or CDK-4
Subramaniam et al., Oncogene 1998 (Burkitt Lymphoma) : The type II IFN IFNgamma , which does not inhibit the growth of Daudi cells, did not induce the expression of p21WAF1 , nor affect the expression of surface IgM
Hobeika et al., Int J Cancer 1998 (Neoplasm Invasiveness...) : IFNgamma induction of p21WAF1 in prostate cancer cells : role in cell cycle, alteration of phenotype and invasive potential ... We now show that the type II IFN IFN gamma similarly induces the expression of p21WAF1 and inhibits the cell cycle of DU145 cells