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IGF1 — IRS4

Pathways - manually collected, often from reviews:

• Reactome Reaction: IGF1 → IRS4 (reaction) Qu et al., J Biol Chem 1999*, Karas et al., Endocrinology 2001, Huang et al., FEBS Lett 2001*, Schreyer et al., Endocrinology 2003, Kim et al., Oncogene 2004, Karlsson et al., Eur J Biochem 2004*, Rakatzi et al., Arch Physiol Biochem 2006, Cuevas et al., J Hepatol 2007, Craparo et al., J Biol Chem 1995*, He et al., J Biol Chem 1995*, Siemeister et al., J Biol Chem 1995, Xu et al., J Biol Chem 1995, Takahashi et al., Endocrinology 1997, Fantin et al., J Biol Chem 1998, Kim et al., Endocrinology 1998, Kim et al., J Biol Chem 1998
• Reactome Reaction: IGF1 → IRS4 (indirect_complex) Qu et al., J Biol Chem 1999*, Karas et al., Endocrinology 2001, Huang et al., FEBS Lett 2001*, Schreyer et al., Endocrinology 2003, Kim et al., Oncogene 2004, Karlsson et al., Eur J Biochem 2004*, Rakatzi et al., Arch Physiol Biochem 2006, Cuevas et al., J Hepatol 2007, Craparo et al., J Biol Chem 1995*, He et al., J Biol Chem 1995*, Siemeister et al., J Biol Chem 1995, Xu et al., J Biol Chem 1995, Takahashi et al., Endocrinology 1997, Fantin et al., J Biol Chem 1998, Kim et al., Endocrinology 1998, Kim et al., J Biol Chem 1998

Text-mined interactions from Literome

Schreyer et al., Endocrinology 2003 : In human skeletal muscle cells, both IRS-1 and IRS-2 are rapidly phosphorylated on tyrosine in response to insulin, whereas essentially no tyrosine phosphorylation of IRS-4 was observed in response to both insulin and IGF-I
Cuevas et al., J Hepatol 2007 : Herein, we report IRS-4 expression in a human hepatoblastoma cell line ( HepG2 ) and IGF-I dependent IRS-4 tyrosine phosphorylation
Madoff et al., Biochem J 1988 : Whereas pp160 remains maximally phosphorylated on tyrosine for up to 60 min in the presence of 100 nM-insulin, IGF-1 at the same concentration induces only a transient response that is maximally 50 % of that observed with insulin