Gene interactions and pathways from curated databases and text-mining

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IGFBP1 — MTOR

Text-mined interactions from Literome

Patel et al., Biochem J 2002 : Our results support the view that the insulin mediated repression of IGFBP-1 gene expression is partly mTOR dependent , and demonstrate that H ( 2 ) O ( 2 ) selectively antagonizes mTOR dependent insulin action
Mounier et al., Endocrinology 2006 : In confluent hepatocytes, insulin could not activate the phosphatidylinositol 3-kinase ( PI3 kinase ) -Akt-Foxo1/Foxo3 pathway, but still inhibited IGFBP-1 gene expression in an mTOR dependent manner
Patel et al., J Biol Chem 2002 : We propose that these observations indicate that an mTOR dependent, but S6K independent mechanism regulates the suppression of IGFBP-1 ( but not G6Pase ) gene expression by insulin