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IGFBP5 — MAPK3

Text-mined interactions from Literome

Fleming et al., J Endocrinol 2007 (MAP Kinase Signaling System) : The IGFBP-5 mRNA response to MAPK inhibitors was specific for MEC, as blocking MAPK activity decreased the ability of IGF-I to induce IGFBP-5 in MF
Kim et al., Biofactors 2007 : In addition, because extracellular signal regulated kinases 1 and 2 ( Erk 1/2 ) affect cell growth, we evaluated the effects of IGFBP-5 on Erk 1/2 phosphorylation in MC3T3-E1 cells ... These data suggest that IGFBP-5 regulates Erk 1/2 phosphorylation in cultured MC3T3-E1 cells via ECM proteins that may ultimately stimulate the growth of osteoblasts
Yasuoka et al., Am J Pathol 2009 (Pulmonary Fibrosis) : We demonstrate for the first time that IGFBP-5 induction of extracellular matrix occurs independently of IGF-I, and results from IGFBP-5 activation of MAPK signaling, which facilitates the translocation of IGFBP-5 to the nucleus ... Egr-1 was up-regulated by IGFBP-5 in a MAPK dependent manner and bound to nuclear IGFBP-5