Gene interactions and pathways from curated databases and text-mining

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IKBKAP — RELA

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Awane et al., J Immunol 1999 : Furthermore, IL-17 induction of the CINC promoter could be inhibited by kinase negative mutants of NF-kappa B-inducing kinase and I kappa B kinase-alpha
Jeong et al., J Biol Chem 1999 : The reduction of IkappaBalpha by DZA is neither involved in IkappaB kinase complex activation nor modulated by the addition of homocysteine
Jue et al., J Korean Med Sci 1999 (Arthritis, Rheumatoid) : Aspirin and sodium salicylate inhibit activation of NF-KB by blocking IkappaB kinase , a key enzyme in NF-kappaB activation
Hehner et al., J Immunol 1999 : The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex
Zamanian-Daryoush et al., Mol Cell Biol 2000 : NF-kappaB activation by double-stranded-RNA activated protein kinase ( PKR ) is mediated through NF-kappaB inducing kinase and IkappaB kinase
Gil et al., Oncogene 2000 : Activation of NF-kappa B by the dsRNA dependent protein kinase, PKR involves the I kappa B kinase complex
Silverman et al., Genes Dev 2000 : Remarkably, this Drosophila IkappaB kinase complex is not required for the activation of the Rel proteins Dif and Dorsal through the Toll signaling pathway, which is essential for antifungal immunity and dorsoventral patterning during early development ... Thus, a yet to be identified IkappaB kinase complex must be required for Rel protein activation via the Toll signaling pathway
Deng et al., Cell 2000 : Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin conjugating enzyme complex and a unique polyubiquitin chain
Chen et al., Mol Pharmacol 2001 : TNF-alpha- or C2-ceramide induced COX-2 promoter activity was inhibited by the dominant negative mutant of extracellular signal regulated kinase 2, p38, JNK, IkappaB kinase (IKK)1 , or IKK2 ... TNF-alpha- or C2-ceramide induced COX-2 promoter activity was inhibited by the dominant negative mutant of extracellular signal regulated kinase 2, p38, JNK, IkappaB kinase (IKK)1 , or IKK2
Matsushima et al., J Exp Med 2001 : Both nuclear factor (NF)-kappaB inducing kinase ( NIK ) and inhibitor of kappaB (IkappaB) kinase ( IKK ) have been implicated as essential components for NF-kappaB activation in response to many external stimuli
Donepudi et al., J Immunol 2001 (Mast-Cell Sarcoma) : Moreover, exposure of P815 tumor cells to a cell-permeable peptide that selectively inhibits NF-kappaB activation by blocking the activation of the IkappaB-kinase complex was found to inhibit the L-PAM induced B7-1 mRNA accumulation, indicating that NF-kappaB activation is essential for the L-PAM induced B7-1 gene expression
Tu et al., J Immunol 2001 : TNF-alpha induces activation of inhibitor of NF-kappaB (IkappaB) kinase-beta ( IKK-beta ), a protein kinase that phosphorylates the NF-kappaB inhibitor IkappaB, and thereby targets the latter for degradation via the ubiquitin-proteasome pathway
Zhang et al., FASEB J 2001 : Furthermore, LA dose-dependently inhibited TNF-alpha induced IkappaB kinase activation , subsequent degradation of IkappaB, the cytoplasmic NF-kappaB inhibitor, and nuclear translocation of NF-kappaB
Zingarelli et al., FASEB J 2002 (Myocardial Infarction...) : These events were preceded by degradation of inhibitor kappaBalpha ( IkappaBalpha ), activation of IkappaB kinase complex (IKK) and c-Jun-NH2-terminal kinase (JNK), and subsequently activation of nuclear factor-kappaB (NF-kappaB) and activator protein 1 (AP-1) as early as 15 min after reperfusion ... These events were preceded by degradation of inhibitor kappaBalpha ( IkappaBalpha ), activation of IkappaB kinase complex (IKK) and c-Jun-NH2-terminal kinase (JNK), and subsequently activation of nuclear factor-kappaB (NF-kappaB) and activator protein 1 (AP-1) as early as 15 min after reperfusion ... These events were preceded by degradation of inhibitor kappaBalpha ( IkappaBalpha ), activation of IkappaB kinase complex (IKK) and c-Jun-NH2-terminal kinase (JNK), and subsequently activation of nuclear factor-kappaB (NF-kappaB) and activator protein 1 (AP-1) as early as 15 min after reperfusion
Wong et al., Shock 2002 (Hyperoxia...) : Hyperoxia prolongs tumor necrosis factor-alpha mediated activation of NF-kappaB : role of IkappaB kinase
Feng et al., Am J Physiol Gastrointest Liver Physiol 2002 (Necrosis) : STS activated I kappa B kinase and nuclear factor-kappa B (NF-kappa B) nuclear translocation and DNA binding but inhibited transactivation of I kappa B-alpha, inducible nitric oxide synthase, and inhibitor of apoptosis protein-1 in hepatocytes and NF-kappa B reporter in transfected Huh-7 cells
Su et al., Nat Immunol 2002 (Lymphoma, B-Cell) : PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling
Chen et al., Inflammation 2002 : In addition, EGCG inhibited TNF-alpha mediated activation of IkappaB kinase and subsequent activation of the IkappaB alpha/NF-kappaB pathway
Kiriakidis et al., J Cell Sci 2003 (Inflammation...) : VEGF expression in human macrophages is NF-kappaB dependent : studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2
Anest et al., Nature 2003 : NF-kappaB is a principal transcriptional regulator of diverse cytokine mediated processes and is tightly controlled by the IkappaB kinase complex ( IKK-alpha/beta/gamma )
Huang et al., J Biomed Sci 2003 : We found that LPS induced I kappa B kinase and nuclear factor-kappa B (NF-kappa B) activation, as well as IFN-gamma induced signal transducer and activator of transcription 1 ( STAT1 ) phosphorylation, were reduced by lovastatin
Park et al., J Biol Chem 2003 : Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha induced NF-kappa B activation
Tang et al., J Biol Chem 2003 : A role for NF-kappaB essential modifier/IkappaB kinase-gamma ( NEMO/IKKgamma ) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha ... NEMO ( NF-kappaB essential modifier ) /IKKgamma ( IkappaB kinase-gamma ) is required for the activation of the IkappaB kinase complex (IKK) by inflammatory stimuli such as tumor necrosis factor ( TNF-alpha )
Ma et al., Mol Pharmacol 2003 : Analyses of the NF-kappaB activation pathway revealed that the antioxidants do not inhibit LPS induced activation of the IkappaB kinase activity, degradation of IkappaBalpha, or translocation of activated NF-kappaB into the nucleus, but they do block the formation of NF-kappaB/DNA binding complexes
Channavajhala et al., J Biol Chem 2003 (MAP Kinase Signaling System) : This inhibition is specific to Cot, because Ras induced ERK and IkappaB kinase induced NF-kappaB activation are not significantly affected by hKSR-2 co-expression
Prajapati et al., J Biol Chem 2004 : Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity
Zingarelli et al., J Immunol 2003 (Bacteremia...) : These events were preceded by degradation of inhibitor kappaBalpha ( IkappaBalpha ), activation of IkappaB kinase complex , and c-Jun NH ( 2 ) -terminal kinase and, subsequently, activation of NF-kappaB and AP-1 in the lung ... These events were preceded by degradation of inhibitor kappaBalpha ( IkappaBalpha ), activation of IkappaB kinase complex , and c-Jun NH ( 2 ) -terminal kinase and, subsequently, activation of NF-kappaB and AP-1 in the lung
Eickhoff et al., J Biol Chem 2004 (Cytomegalovirus Infections) : A stable inhibitor of NF-kappaB ( IkappaB ) reverses the RICK inhibitory effect, and activation of NF-kappaB by IkappaB kinase beta expression is inhibitory to HCMV, demonstrating that NF-kappaB activation is part of a potent anti-HCMV response
Luftig et al., Proc Natl Acad Sci U S A 2003 : LMP1 activates the IkappaB kinase complex and NF-kappaB through two cytoplasmic signaling domains that engage tumor necrosis factor receptor associated factor ( TRAF)1/2/3/5 or TRADD and RIP
Huang et al., J Biol Chem 2004 : Activation of NFkappaB requires the activity of IkappaB kinase , a kinase complex that contains two catalytic subunits, IKKalpha and IKKbeta, and a non-enzymatic regulatory subunit, IKKgamma
Kim et al., Infect Immun 2004 (Enteritis...) : Stable expression of dominant negative ( DN ) Nod1 in colon epithelial cells prevented IkappaB kinase and NF-kappaB activation in response to infection with enteroinvasive Escherichia coli
MacMaster et al., Inflamm Res 2003 (Colitis...) : An inhibitor of IkappaB kinase , BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium induced colitis in mice
Watanabe et al., Proc Natl Acad Sci U S A 2004 (MAP Kinase Signaling System) : The NF-kappaB translocation dependent pathway involves NF-kappaB inducing kinase-IkappaB kinase beta/gamma dependent phosphorylation and degradation of IkappaBalpha, whereas the NF-kappaB translocation independent pathway involves mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase kinase kinase 1-dependent activation of MAPK kinase 3/6-p38 MAPK pathway
Lamkanfi et al., J Biol Chem 2004 (MAP Kinase Signaling System) : We demonstrate that caspase-1 interacts with RIP2 and that dominant negative forms of RIP2 and IkappaB kinase complex-beta inhibit caspase-1 mediated NF-kappaB activation
Lee et al., J Biol Chem 2004 : The kinase activity of Rip1 is not required for tumor necrosis factor-alpha induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2 ... The kinase activity of Rip1 is not required for tumor necrosis factor-alpha induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2
Krappmann et al., Mol Cell Biol 2004 : The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide induced gene expression and control subordinate activation of AP-1
Khoshnan et al., J Neurosci 2004 (Nerve Degeneration) : In inducible PC12 cells and in HD transgenic mice, mutant Htt activates the IkappaB kinase complex (IKK) , a key regulator of NF-kappaB ... In inducible PC12 cells and in HD transgenic mice, mutant Htt activates the IkappaB kinase complex (IKK) , a key regulator of NF-kappaB
Chang et al., Mol Pharmacol 2004 : The dominant negative mutants of NIK and various IkappaB kinase complexes, including IKKbeta ( Y188F ), IKKbeta ( Y199F ), and IKKbeta ( FF ), inhibited the COX-2 promoter activity
Aneja et al., Mol Med 2004 (Myocardial Reperfusion Injury) : These events were associated with cytosol degradation of inhibitor kappaB-alpha, activation of IkappaB kinase , phosphorylation of c-Jun, and subsequent activation of nuclear factor-kappaB and activator protein-1 in the infarcted heart
Panopoulos et al., J Biol Chem 2005 (Inflammation) : Iron mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha induced but not interleukin-1beta induced IkappaB kinase complex/nuclear factor-kappaB activation
Mukundan et al., J Immunol 2005 : However, ligation of a CD40 mutant lacking a functional TRAF6 binding site did not initiate inflammatory cytokine production, and this mutant was found to be defective in CD40 mediated activation of ERK1/2, as well as IkappaB kinase (IKK) and NF-kappaB
Chan et al., Biochem Biophys Res Commun 2005 : Tpl2/COT1 was shown to participate in CD40 signaling based on the ability of a catalytically inactive mutant to suppress CD40 mediated IkappaB kinase activation and induction of NFkappaB-responsive promoters, without affecting signaling by TNF ... Tpl2/COT1 was shown to participate in CD40 signaling based on the ability of a catalytically inactive mutant to suppress CD40 mediated IkappaB kinase activation and induction of NFkappaB-responsive promoters, without affecting signaling by TNF
Mortaz et al., Biochem Pharmacol 2005 : We thus propose that the anti-inflammatory effects of ASA in mast cells are due to suppression of IkappaB kinase activity, thereby inhibiting subsequent phosphorylation and degradation of IkappaB-alpha, activation of NF-kappaB , and transcription of proinflammatory cytokines ... We thus propose that the anti-inflammatory effects of ASA in mast cells are due to suppression of IkappaB kinase activity, thereby inhibiting subsequent phosphorylation and degradation of IkappaB-alpha , activation of NF-kappaB, and transcription of proinflammatory cytokines
Nonaka et al., Oncogene 2005 (Cell Transformation, Neoplastic...) : We also demonstrate that overexpression of CD30 in rat fibroblasts at levels comparable to those in H-RS cells results in constitutive IkappaB kinase activation, proteasome dependent p100 processing, and NF-kappaB dependent cell transformation
Peng et al., J Leukoc Biol 2005 : Here, we demonstrated that inhibition of inhibitor of kappaB (IkappaB) kinase ( IKK ) by a peptide IKK inhibitor or by four individual chemical IKK inhibitors including 15-deoxy-prostaglandin J ( 2 ), BMS-345541, SC-514, or sulindac significantly blocked IgE + trinitrophenyl ( TNP ) -induced TNF production by mouse bone marrow derived MC ( BMMC )
Reiley et al., Mol Cell Biol 2005 : Interestingly, the CYLD phosphorylation requires IkappaB kinase gamma (IKKgamma) and can be induced by IKK catalytic subunits
Azoitei et al., J Neurochem 2005 : Activation of the IkappaB kinase complex is sufficient for neuronal differentiation of PC12 cells ... We examined the role of the IkappaB kinase complex in nerve growth factor (NGF) induced neuronal differentiation of PC12 cells
Kim et al., Immunology 2005 : Moreover, in vitro kinase assays show that luteolin directly inhibits LPS induced IkappaB kinase (IKK) activity in IEC-18 cells
Chao et al., Am J Physiol Heart Circ Physiol 2005 : In CMs, FADD inhibited NF-kappaB activation as well as phosphorylation of IkappaB-alpha and IkappaB kinase (IKK)-beta in response to cytokine stimulation or expression of the upstream kinases NF-kappaB inducing kinase and IKK-beta
Cusson-Hermance et al., J Biol Chem 2005 : Rip1 is required for IkappaB kinase activation in response to tumor necrosis factor alpha (TNF-alpha) and has been implicated in the Toll-like receptor 3 (TLR3) response to double stranded RNA ... Rip1 is required for IkappaB kinase activation in response to tumor necrosis factor alpha (TNF-alpha) and has been implicated in the Toll-like receptor 3 (TLR3) response to double stranded RNA
Aggarwal et al., Mol Pharmacol 2006 (Neoplasm Metastasis) : Curcumin also suppressed NF-kappaB reporter activity induced by tumor necrosis factor receptor (TNFR)1, TNFR2, NF-kappaB inducing kinase, IkappaB kinase complex (IKK) , and the p65 subunit of NF-kappaB
Yanaka et al., Int J Mol Med 2005 : Although vitamin B6 did not affect cellular proteasome activity, in vitro phosphorylation analysis with glutathione S-transferase fused IkappaBalpha has shown that vitamin B6 suppressed LPS induced IkappaB kinase activation
Guasparri et al., EMBO Rep 2006 : TRAF2 , but not TRAF3, mediates the association of vFLIP with the IkappaB kinase complex ... TRAF2, but not TRAF3 , mediates the association of vFLIP with the IkappaB kinase complex
Haase et al., J Immunol 2005 (Yersinia Infections) : TAK1 is an important activator of the IkappaB kinase complex in the TLR signaling cascade
Griffin et al., J Biol Chem 2006 (Astrocytoma...) : However, in vitro analysis of enzyme activity demonstrates that IL-1beta causes the long term activation of the IkappaB kinase complex leading to chronic phosphorylation of the newly synthesized IkappaBalpha signal response domain and persistent activation of NFkappaB
Song et al., Proc Natl Acad Sci U S A 2006 : Because IRAK1 is upstream of TRAF6 in IL-1 activation of NF-kappaB, the potential role of IRAK1 in LMP1 mediated NF-kappaB activation through TRAF6 and inhibitor of kappaB (IkappaB) kinase ( IKK ) was initially investigated
Xie et al., Toxicological sciences : an official journal of the Society of Toxicology 2006 : The activity of tumor necrosis factor-alpha induced inhibitor of kappa B (IkappaB) kinase alpha was also inhibited by Cd
Chen et al., J Immunol 2006 : Peptidoglycan induced IL-6 production in RAW 264.7 macrophages is mediated by cyclooxygenase-2, PGE2/PGE4 receptors, protein kinase A, I kappa B kinase , and NF-kappa B
Adli et al., J Biol Chem 2006 (Inflammation) : NF-kappaB activation downstream of lipopolysaccharide or cytokine stimulation is controlled by the IkappaB kinase complex , which contains IKKalpha and IKKbeta
Parameswaran et al., J Biol Chem 2006 : Upon LPS stimulation, IkappaB kinase promotes phosphorylation and degradation of NFkappaB1 p105 ( p105 ) , which releases TPL2 ( a MAP3K ), which phosphorylates MEK1/2, which in turn phosphorylates ERK1/2
Edwards et al., Mol Immunol 2007 : Focusing on CXCL8, both rhinovirus infection and dsRNA treatment required IkappaB kinase-beta for induction of CXCL8
Gilmore et al., Oncogene 2006 : NF-kappaB signaling is primarily regulated by inhibitor kappaB ( IkappaB ) proteins and the IkappaB kinase complex through two major pathways : the canonical and non-canonical NF-kappaB pathways
Zhang et al., PloS one 2006 : Both phenotypes are rescued by injection of RNA encoding the anti-apoptotic protein Bcl-xL ; Bcl-xL 's effects are dependent upon IkappaB kinase mediated activation of the bipartite transcription factor NF-kappaB
Ckless et al., Am J Respir Cell Mol Biol 2007 : Conversely, overexpression of arginase I decreased cellular S-nitrosothiol content and enhanced IkappaB kinase activity and NF-kappaB DNA binding, and decreased S-nitrosation of p50
Ha et al., J Immunol 2007 : Moreover, IkappaB kinase (IKK) alpha and IKKbeta are distinctly involved in MUC5AC induction via an ERK1 dependent, but IkappaBalpha-p65- and p100-p52 independent, mechanism, thereby revealing novel roles for IKKs in mediating up-regulation of MUC5AC mucin by S. pneumoniae
Tomimori et al., Infect Immun 2007 (Helicobacter Infections) : Transfection of IkappaB kinase and NF-kappaB inducing kinase dominant negative mutants inhibited H. pylori mediated activation of CCL20
von Bülow et al., J Immunol 2007 (MAP Kinase Signaling System) : By this mechanism, zinc suppressed LPS induced activation of IkappaB kinase beta (IKKbeta) and NF-kappaB, and subsequent TNF-alpha production
Tudhope et al., J Immunol 2007 : The role of IkappaB kinase 2, but not activation of NF-kappaB , in the release of CXCR3 ligands from IFN-gamma stimulated human bronchial epithelial cells
Shultz et al., J Interferon Cytokine Res 2007 : Activation of NF-kappaB requires the inhibitor of kappaB (IkappaB) kinase ( IKK) complex, which is made up of two functional kinases, IKKalpha and IKKbeta, and the scaffolding protein IKKgamma
Teruya et al., BMC microbiology 2007 : Collectively, these results suggest that L. pneumophila induces activation of NF-kappaB through an intracellular signaling pathway that involves NF-kappaB inducing kinase and IkappaB kinase , leading to IL-8 gene transcription, and that hsp90 acts as a crucial regulator in L. pneumophila induced IL-8 expression, presumably contributing to immune response in L. pneumophila
Kim et al., Mol Pharmacol 2008 (Inflammation...) : Here, we demonstrate that the novel small-molecule benzoxathiole 6,6-dimethyl-2- ( phenylimino ) -6,7-dihydro-5H-benzo- [ 1,3 ] oxathiol-4-one ( BOT-64 ) inhibits NF-kappaB activation with an IC ( 50 ) value of 1 muM by blocking inhibitory kappaB(IkappaB) kinase beta ( IKKbeta ), and suppresses NF-kappaB regulated expression of inflammatory genes in lipopolysaccharide (LPS) activated RAW 264.7 macrophages
Boersma et al., Science signaling 2008 : Transcriptional activation by NF-kappaB and chromatin remodeling by inhibitor of kappaB (IkappaB) kinase complex ( IKK ) have been linked to recall and reconsolidation of conditioned fear memories in the mammalian central nervous system
Neil et al., Cancer Res 2008 (Disease Progression) : Altered TAB1 : I kappaB kinase interaction promotes transforming growth factor beta mediated nuclear factor-kappaB activation during breast cancer progression
Ragheb et al., Biochem Biophys Res Commun 2008 (Disease Models, Animal...) : Interestingly, IkappaB-kinase beta (IKKbeta) dependent NF-kappaB was activated in hepatocytes from the fructose fed hamster as an indication for PKC activation
Hagemann et al., J Exp Med 2008 (Neoplasms) : We show that macrophages are polarized via interleukin (IL)-1R and MyD88 to an immunosuppressive `` alternative '' phenotype that requires IkappaB kinase beta mediated NF-kappaB activation
Huang et al., Int J Cardiol 2009 (Atherosclerosis) : Metformin inhibits TNF-alpha induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K dependent AMPK phosphorylation
Naidu et al., J Immunol 2008 : PMA dependent HO-1 gene activation was reduced by an overexpressed dominant negative mutant of IkappaBalpha, but not by dominant negative IkappaB kinase-2 , suggesting that the classical NF-kappaB pathway was not involved in this regulation
Kim et al., Mol Cancer Res 2008 (Glioma) : Here, we report that the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin ( 17-AAG ) blocks MMP-9 secretion and that HA-induced nuclear factor-kappaB (NF-kappaB) activation is mediated by IkappaB kinase , which phosphorylates the NF-kappaB inhibitor IkappaBalpha and promotes its degradation ... Here, we report that the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin ( 17-AAG ) blocks MMP-9 secretion and that HA-induced nuclear factor-kappaB (NF-kappaB) activation is mediated by IkappaB kinase , which phosphorylates the NF-kappaB inhibitor IkappaBalpha and promotes its degradation ... Here, we report that the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin ( 17-AAG ) blocks MMP-9 secretion and that HA-induced nuclear factor-kappaB (NF-kappaB) activation is mediated by IkappaB kinase , which phosphorylates the NF-kappaB inhibitor IkappaBalpha and promotes its degradation
Fan et al., J Biol Chem 2009 (MAP Kinase Signaling System...) : The ability of Src to enhance SF stimulation of NF-kappaB activity was due, in part, to its ability to stimulate Akt and IkappaB kinase activity ; and Src mediated stimulation of NF-kappaB was due , in part, to a Rac1/MKK3/6/p38 pathway and was Akt dependent
Tsutsui et al., Bioorg Med Chem Lett 2009 (Inflammation) : Consistent with these results, peperomin E and 2,6-didehydropeperomin B blocked the TNF-alpha induced activation of IkappaB kinase , while they had no direct effect on the IkappaB kinase activity
Funakoshi-Tago et al., Mol Pharmacol 2009 : Whereas licochalcone A had no effect on the recruitment of receptor interacting protein 1 and IkappaB kinase beta (IKKbeta) to TNF receptor I by TNF-alpha, it significantly inhibited TNF-alpha induced IkappaB kinase complex (IKK) activation and inhibitor of nuclear factor-kappaB degradation
Shih et al., Eur J Pharmacol 2009 : In this study, we investigated the involvement of the extracellular signal regulated kinase ( ERK ), IkappaB kinase alpha/beta ( IKKalpha/beta ), and nuclear factor-kappaB (NF-kappaB) signaling pathways in thrombin induced COX-2 expression in human lung fibroblasts ( WI-38 )
Joo et al., Eur J Pharmacol 2009 (Colitis) : In HCT116 cells, the inhibitory effect by TauCl or 5-ASA was through preventing IL-1beta induced IkappaB kinase activation and subsequently interfering with IkappaBalpha degradation and p65 nuclear accumulation
Liu et al., Proc Natl Acad Sci U S A 2009 : Neither JNK1 activation by IL-1beta or UV nor TNF-alpha induced activation of p38, ERK, or IkappaB kinase complex is affected by the loss of Miz1 ... Neither JNK1 activation by IL-1beta or UV nor TNF-alpha induced activation of p38, ERK, or IkappaB kinase complex is affected by the loss of Miz1 ... Neither JNK1 activation by IL-1beta or UV nor TNF-alpha induced activation of p38, ERK, or IkappaB kinase complex is affected by the loss of Miz1
Shultz et al., J Interferon Cytokine Res 2009 : In response to IFN-gamma , inhibitor of NF-kappaB (IkappaB) kinase beta ( IKK-beta ) is required to activate both newly synthesized IRF1 and the p65 subunit of NF-kappaB, which contributes to ip-10 expression by binding to kappaB sites in the ip-10 promoter, with little or no activation of classical NF-kappaB ... In response to IFN-gamma, inhibitor of NF-kappaB (IkappaB) kinase beta ( IKK-beta ) is required to activate both newly synthesized IRF1 and the p65 subunit of NF-kappaB, which contributes to ip-10 expression by binding to kappaB sites in the ip-10 promoter, with little or no activation of classical NF-kappaB
Dong et al., Exp Mol Med 2010 (Lung Neoplasms) : Moreover, beta-lap markedly suppressed the activation of IkappaB kinase gamma (IKKgamma) and the subsequent phosphorylation of IkappaBalpha, thereby inhibiting NF-kappaB activation
Tanabe et al., Journal of neuroinflammation 2010 (Glioma) : Wedelolactone, an inhibitor of IkappaB kinase , suppressed both TNF-alpha induced IkappaB phosphorylation and NFkappaB phosphorylation at Ser 536 and Ser 468
Chen et al., TheScientificWorldJournal 2010 : Blocking phosphorylation of ERK1/2 by MAPK inhibitors U0126 and PD98059, and inhibiting activation of NF-?B by IkappaB ( I?B ) kinase inhibitors wedelolactone or IMD-0354, abolished the DSP effects
Sarkar et al., Mol Cell Biol 2011 : RNA binding protein AUF1 regulates lipopolysaccharide induced IL10 expression by activating IkappaB kinase complex in monocytes ... RNA binding protein AUF1 regulates lipopolysaccharide induced IL10 expression by activating IkappaB kinase complex in monocytes
Diaz-Meco et al., EMBO J 1994 : MBP-zeta PKC, but not MBP, bound and activated a potentially novel I kappa B kinase of approximately 50 kDa molecular weight able to regulate I kappa B-alpha function
Lee et al., Proc Natl Acad Sci U S A 1998 : We have previously shown that mitogen activated protein kinase/ERK kinase kinase 1 ( MEKK1 ) can induce both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight IkappaB kinase complex in vitro ... We have previously shown that mitogen activated protein kinase/ERK kinase kinase 1 ( MEKK1 ) can induce both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight IkappaB kinase complex in vitro
Uhlik et al., J Biol Chem 1998 : NF-kappaB inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax mediated NF-kappaB activation