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IL1A — PI3

Text-mined interactions from Literome

Maraldi et al., Adv Enzyme Regul 1999 (Osteosarcoma) : In fact, inactivation by two independent mechanisms, addition of specific PI 3-kinase inhibitors, or overexpression of a mutant form of IL-1RI , resulted in a substantial inhibition of PI 3-kinase translocation to the nucleus
Buhrmann et al., J Biol Chem 2011 (Inflammation) : Curcumin suppressed IL-1ß induced PI-3K p85/Akt activation and its association with IKK
Lee et al., Invest Ophthalmol Vis Sci 2012 : Brief stimulation of CECs with IL-1ß upregulated expression of IRAK and TRAF6 and activated PI 3-kinase ; expression of IRAK and TRAF6 reached maximum within 60 minutes, after which the expression disappeared, while PI 3-kinase activity was observed up to 4 hours after IL-1ß stimulation
Marmiroli et al., FEBS Lett 1998 (Osteosarcoma) : This observation prompted us to investigate the role of PI 3-kinase in IL-1 signalling ... Expression of a receptor mutant lacking the putative binding site for p85 demonstrates that Tyr479 in the receptor cytoplasmic domain is essential for PI 3-kinase activation by IL-1
Bavelloni et al., J Cell Sci 1999 (Osteosarcoma) : Both immunoblotting and immunofluorescence data indicate that IL-1 causes a rapid and transient translocation of PI3-kinase from the cytoplasm to the nucleus ... Indeed, in cell clones stably transfected with Y479F receptor mutant, in which the binding of the enzyme to the activated receptor is blocked, IL-1 induced PI3-kinase translocation to the nucleus is completely prevented