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CASP16 — IL1B
Text-mined interactions from Literome
Pirhonen et al., J Immunol 1999
:
Since caspase-1 is known to cleave proIL-1 beta and proIL-18 into their mature, active forms, we analyzed the
effect of a specific
caspase-1 inhibitor on virus induced
IL-1 beta and IL-18 production ... Furthermore, the virus induced activation of
caspase-1 is
required for the efficient production of biologically active
IL-1 beta and IL-18
Zeuner et al., Cell Death Differ 1999
:
In addition to the well established
role of
caspase-1 in the production of active
IL-1beta and IL-18 in inflammation,4 an increasing number of reports has recently suggested that caspases may have a function outside of apoptosis
Laliberte et al., J Biol Chem 1999
:
Characterization of the pharmacological sensitivity of this stimulus coupled response revealed that some
caspase-1 inhibitors
allow pro-IL-1beta secretion, whereas others do not
Humke et al., Cell 2000
:
ICEBERG is a novel protein that
inhibits generation of
IL-1beta by interacting with
caspase-1 and preventing its association with RIP2
Nonaka et al., J Periodontal Res 2001
:
IL-1beta secretion was
blocked by the
caspase-1 inhibitor, Z-VAD-FMK, indicating that caspase-1 is involved in not only the induction of apoptosis but also the IL-1beta secretion from A. actinomycetemcomitans infected J774.1 cells
Lee et al., J Biol Chem 2001
:
The production of bio-active
interleukin-1beta (IL-1beta) , a pro-inflammatory cytokine, is
mediated by activated
caspase-1
Carpenter et al., Diabetes 2002
:
That
IL-1beta also
activated caspase-3 and promoted PKCdelta cleavage suggests that this distal pathway also contributes in the apoptotic response to the cytokine
Lynch et al., Eur J Neurosci 2002
(MAP Kinase Signaling System) :
Analysis of colocalization of activated caspase-3 with activated p38 ( p-p38 ) suggested that p-p38 was necessary for activation of caspase-3 ; while in vitro analysis indicated that the
IL-1beta induced increase in
caspase-3 activity was abrogated by the p38 inhibitor, SB203580 ... The
IL-1beta induced increase in
caspase-3 activity in vitro was also abrogated by vasoactive intestinal peptide, which is a JNK inhibitor ; however, colocalization of activated JNK ( p-JNK ) and activated caspase-3 did not clearly identify JNK as an upstream activator of caspase-3
Martinon et al., Mol Cell 2002
(Inflammation) :
Generation of Interleukin
(IL)-1beta via cleavage of its proform
requires the activity of
caspase-1 ( and caspase-11 in mice ), but the mechanism involved in the activation of the proinflammatory caspases remains elusive
Schauvliege et al., J Biol Chem 2002
:
Murine
caspase-11 , together with caspase-1, is
essential for the production of
IL-1beta in response to lipopolysaccharide (LPS)
Kang et al., Cell Death Differ 2002
(Disease Models, Animal...) :
The early activation of caspases-3/-7 by
caspase-11 was not
affected by blocking of caspase-1 activity and
IL-1beta release, implying that caspase-11 activates caspases-3/-7 independently of caspase-1 activation
Evans et al., Gastroenterology 2002
(Inflammatory Bowel Diseases) :
In peripheral blood mononuclear cells, inhibition of
caspase 1
reduced interleukin-1beta secretion, whereas blockade of phagocytosis inhibited calcium induced apoptosis and
interleukin-1beta release
Yoo et al., Biochem Biophys Res Commun 2002
:
The production of bioactive
interleukin-1beta (IL-1beta) , a pro-inflammatory cytokine, is
mediated by activated
caspase-1 ... Nod1 enhances
caspase-1 induced
IL-1beta secretion, as well as lipopolysaccharide (LPS) induced IL-1beta secretion in transfected cells
Wang et al., Br J Pharmacol 2003
(Hypercholesterolemia...) :
8. This study demonstrates that injection of a selective caspase-1 inhibitor after myocardial ischaemia markedly reduced the detrimental effect conferred by hypercholesterolaemia on myocardial ischaemia-reperfusion injury by attenuating both necrotic as well as apoptotic cell death pathways through inhibition of
IL-1beta production and
activation of
caspase-1 and caspase-3
Stuyt et al., Cytokine 2003
:
Inhibition of
caspase-1 reduced IFN-gamma and
IL-1beta levels ( by 80 and 67 %, respectively ) when heat killed S. epidermidis was added to whole human blood cultures
Jendrossek et al., Infect Immun 2003
:
In addition, only the piliated wild-type strains induced
caspase-1 mediated activation of
interleukin-1 beta
Stehlik et al., J Biol Chem 2003
:
In contrast to its effects on Nod1- and Cardiak dependent NF-kappa B activation, CARD6 did not interfere with
caspase-1 dependent
interleukin-1 beta secretion induced by Cardiak or Nod1
Chen et al., Biochem Pharmacol 2003
:
Novel roles for palmitoylation of Ras in
IL-1 beta induced nitric oxide release and
caspase 3 activation in insulin secreting beta cells ... CER-treatment also prevented
IL-1 beta induced activation of
caspase 3 in these cells
Fortunato et al., Placenta 2003
:
When compared to control,
IL-1 beta increased
caspase 2, 3, 8 and 9 activities, whereas IL-6 treated membranes did not exhibit a significant change
Donnelly-Roberts et al., J Pharmacol Exp Ther 2004
(MAP Kinase Signaling System) :
Two
caspase inhibitors, YVAD ( caspase 1 ) and DEVD ( caspase 3 ),
attenuated both BzATP induced pore formation and
IL-1beta release in a concentration dependent fashion ... In contrast, P2X(7)R mediated
IL-1beta release is
dependent on
caspase activity but not p38 MAPK
Veluthakal et al., Am J Physiol Cell Physiol 2004
:
N ( G ) -monomethyl-l-arginine, a known inhibitor of inducible nitric oxide synthetase (iNOS), markedly inhibited
IL-1beta induced iNOS gene expression, NO release,
caspase-3 and caspase-6 activation, lamin B degradation, and loss of metabolic cell viability, indicating that the observed IL-1beta induced effects on nuclear lamin B involve the intermediacy of NO
Basak et al., J Biol Chem 2005
(MAP Kinase Signaling System) :
NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1 mediated
caspase-1 activation
play essential roles in
interleukin-1beta release from Helicobacter pylori lipopolysaccharide stimulated macrophages
Cooke et al., Transplantation 2005
:
In addition, AdvBcl-2 pretreatment led to diminished cytochrome c release into cytosolic extracts and reduced intragraft
IL-1beta production and
inhibited intragraft
caspase-3 and caspase-9 activity
Ubol et al., Microbiol Immunol 2005
(Disease Models, Animal...) :
The first is immune mediated death which may operate through the receptor-ligand pathway
activated by
caspase-1 and the pro-inflammatory cytokine,
IL-1beta
Wang et al., Ann Thorac Surg 2005
(Reperfusion Injury) :
Myocardial tissue was then assessed for products of p38 MAPK activation, expression of tumor necrosis factor,
interleukin-1beta and interleukin-6, and
activation of caspase-1,
caspase-3 and caspase-11
El Btaouri et al., Biochem Biophys Res Commun 2006
(MAP Kinase Signaling System) :
The permeable exogenous C ( 2 ) -ceramide reproduces
IL-1beta effects on: (i) inhibition of adenylyl cyclase activity, ( ii ) down-regulation of ERK1/2 phosphorylation, ( iii ) activation of
caspase-3 , and ( iv ) apoptosis in pig thyroid cells
Shakibaei et al., Ann Anat 2005
:
Additionally, curcumin antagonized
IL-1beta induced
caspase-3 activation in a time dependent manner
Okemoto et al., J Immunol 2006
:
A potent adjuvant monophosphoryl lipid A triggers various immune responses, but not secretion of
IL-1beta or
activation of
caspase-1
MacRae et al., J Endocrinol 2006
:
TNFalpha but not
IL-1beta exposure
led to increased
caspase-3 activity and altered cellular morphology, consistent with reduced viability
Dorfleutner et al., Infect Immun 2007
(Inflammation) :
cPOP2 binds to ASC and PAN1, thereby blocking formation of cryopyrin and PAN1 containing inflammasomes,
activation of
caspase-1 , and subsequent processing and secretion of bioactive
interleukin-1beta
Dinarello et al., Semin Nephrol 2007
(Inflammation...) :
IL-18 is a member of the IL-1 family ;
IL-1beta and IL-18 are related closely, and both
require the intracellular cysteine protease
caspase-1 for biological activity
Boost et al., Intensive Care Med 2007
(Endotoxemia) :
Targeting
caspase-1 by inhalation-therapy :
effects of Ac-YVAD-CHO on
IL-1 beta , IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia
Shakibaei et al., Ann N Y Acad Sci 2007
:
Resveratrol inhibits
IL-1 beta induced stimulation of
caspase-3 and cleavage of PARP in human articular chondrocytes in vitro
Ikeda et al., J Immunol 2007
(MAP Kinase Signaling System) :
The release of UA-induced
IL-1beta was significantly
inhibited by the inhibitors of p38 MAPK, MEK1/2, ATP binding cassette transporter, and
caspase-1
Li et al., J Immunol 2007
:
Aluminum hydroxide adjuvants activate
caspase-1 and
induce IL-1beta and IL-18 release
Dinarello et al., Immunity 2007
(Inflammation) :
Secretion of the proinflammatory cytokine
IL-1beta requires
caspase-1 and Toll-like receptor ( TLR ) signaling
Ahmed et al., J Vet Med Sci 2007
:
However, leptin treatment increased monocyte/macrophages production of
IL-1beta as well as TNF-alpha, and
induced the mRNA expression of
caspase-1 , which is shown to mediate the conversion of latent pro-IL-1beta and pro-IL-18 to active forms
Moore et al., Synapse 2007
(Disease Models, Animal...) :
In parallel with its ability to decrease microglial activation in vivo, we report that treatment of cultured glia with dexamethasone and vitamin D3 blocked the lipopolysaccharide increased MHCII mRNA and IL-1beta concentration, while the
IL-1beta induced increases in activation of JNK and
caspase 3 in cultured neurons were also reversed by treatment with dexamethasone and vitamin D3
Schroeder et al., Microbiology 2007
:
Addition of CCCP 15 min after infection blocked macrophage cell death, the
activation of
caspase-1 and the maturation of
IL-1beta , without affecting uptake or escape of S. flexneri from the phagosome
Holohan et al., J Cell Mol Med 2008
(Insulinoma) :
The broad range
caspase inhibitor, Boc-D-fmk,
blocked IL-1beta/IFNgamma -induced caspase activity, but not nitric oxide production nor cell death
Kuijk et al., Mol Immunol 2008
:
Statin synergizes with LPS to
induce IL-1beta release by THP-1 cells through activation of
caspase-1 ... Taken together, these results demonstrate that simvastatin
augments LPS induced
IL-1beta release post-translationally, by inducing
caspase-1 activity
Miao et al., Proc Natl Acad Sci U S A 2008
:
We demonstrate here that Pseudomonas aeruginosa activates
caspase 1 and
induces IL-1beta secretion in infected macrophages
Rupper et al., Infect Immun 2008
:
The activation of
caspase-1 by the detection of bacterial products through Nod-like receptors
leads to the secretion of mature
interleukin-1beta (IL-1beta) and IL-18 and the induction of rapid host cell death ( pyroptosis )
Gustavsson et al., Retina 2008
(Diabetes Mellitus, Experimental...) :
Ischemia induced increased expressions of TNF-alpha ( P < or= 0.012 ),
IL-1beta ( P < or= 0.017 ), ICAM-1 ( P < or= 0.025 ), and IL-6 ( P = 0.012 ), and diabetes
induced increased expression of
caspase-1 ( P < or= 0.046 ), VCAM-1 ( P < or= 0.027 ), ICAM-1 ( P < or= 0.016 ), IL-1beta ( P = 0.016 ), and IL-6 ( P = 0.041 )
Coppola et al., Int J Biochem Cell Biol 2008
:
In beta-TC3 cells, NT activates both MAP and PI-3 kinases pathways and strongly reduces the staurosporine or the
Il-1beta induced
caspase-3 activity by a mechanism involving Akt activation
Pelegrin et al., J Immunol 2008
:
We delineated two distinct release pathways : the well-known caspase-1 cascade mediating release of processed
IL-1beta that was selectively
blocked by inhibition of
caspase-1 or panx1, and a calcium independent, caspase-1/panx1 independent release of pro-IL-1beta that was selectively blocked by glycine
Kang et al., Eur J Immunol 2008
(Anthrax) :
In contrast, we now report that
caspase-1 mediated
IL-1beta expression in response to BA spores is required for anti-BA host defenses
Hsu et al., Proc Natl Acad Sci U S A 2008
(Anthrax...) :
A NOD2-NALP1 complex mediates
caspase-1 dependent
IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
Hewinson et al., J Immunol 2008
(Ion Channel Gating) :
Inflammatory
caspase-1 is
responsible for the proteolytic activation of
IL-1beta
Yajima et al., Circulation 2008
(Inflammation...) :
Apoptosis associated speck-like protein containing a caspase recruitment domain (ASC) is an adaptor protein that regulates
caspase-1 dependent
IL-1 beta and IL-18 generation ; however, the role of ASC in vascular injury remains undefined
Li et al., J Immunol 2008
(Inflammation) :
We have recently shown that alum activates
caspase-1 and
induces secretion of mature
IL-1beta and IL-18
Shakibaei et al., Biochem Pharmacol 2008
(Osteoarthritis) :
Furthermore, we observed that resveratrol as well as ALLN inhibited
IL-1beta induced apoptosis,
caspase-3 activation and PARP cleavage in human articular chondrocytes
Kuijk et al., Blood 2008
(Mevalonate Kinase Deficiency) :
HMG-CoA reductase inhibition
induces IL-1beta release through Rac1/PI3K/PKB dependent
caspase-1 activation ...
IL-1beta release is
mediated by
caspase-1 , and simvastatin treatment resulted in increased caspase-1 activity in a Rac1/PI3K dependent manner
Maelfait et al., J Exp Med 2008
(Inflammation) :
These results implicate a novel
role for
caspase-8 in the production of biologically active
IL-1beta in response to TLR3 and TLR4 stimulation
González-Benítez et al., Mediators Inflamm 2008
(Inflammation) :
In the inflammosome complex, NALP3 or NALP1 binds to ASC and activates
caspase-1 which
induces IL-1beta
Deng et al., Toxicol Appl Pharmacol 2009
(Periodontitis) :
Furthermore, caspase-1, a promoter of IL-1beta production, was activated by treatment with alendronate, and
caspase-1 inhibitor
reduced the production of
IL-1beta induced by alendronate and P. gingivalis
Wang et al., Stroke 2009
(Brain Ischemia...) :
Mitochondrial membrane potential, release of apoptogenic mitochondrial factors,
pro-IL-1beta processing, and
activation of
caspase -1 and -3 were evaluated ... Methazolamide and melatonin inhibit oxygen/glucose deprivation induced cell death, loss of mitochondrial membrane potential, release of mitochondrial factors,
pro-IL-1beta processing, and
activation of
caspase-1 and -3 in primary cerebrocortical neurons
Hise et al., Cell Host Microbe 2009
(Candidiasis...) :
The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1beta gene transcription, whereas the NLRP3 containing proinflammatory multiprotein complex, the NLRP3 inflammasome, controls
caspase-1 mediated cleavage of
pro-IL-1beta
Zaiss et al., J Immunol 2009
(Adenoviridae Infections) :
In direct correlation with the increased viral internalization, antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes, type I IFNs, and
caspase dependent
IL-1beta maturation
Talabot-Ayer et al., J Biol Chem 2009
:
Consistently,
caspase-1 activation in THP-1 cells
induced cleavage of
pro-IL-1beta but not of pro-IL-33, and activated THP-1 cells released full-length pro-IL-33 into culture supernatants
Franchi et al., J Immunol 2009
(Inflammation) :
In addition to TNF-alpha, IL-1alpha and
IL-1beta promoted
caspase-1 activation via Nlrp3 in response to ATP
Muñoz-Planillo et al., J Immunol 2009
(Inflammation...) :
In this study, we show that the ability of Staphylococcus aureus, a leading cause of infection in humans, to activate
caspase-1 and
induce IL-1beta secretion resides in culture supernatants of growing bacteria
Cho et al., Infect Immun 2010
:
Bacillus anthracis capsule activates
caspase-1 and
induces interleukin-1beta release from differentiated THP-1 and human monocyte derived dendritic cells
Prantner et al., Infect Immun 2009
(Chlamydia Infections) :
By using LPS primed macrophages as a model system, it was determined that
IL-1beta secretion was
dependent on
caspase-1 , potassium efflux, and the activity of serine proteases
Becker et al., J Biol Chem 2009
:
Rab39a binds
caspase-1 and is
required for caspase-1 dependent
interleukin-1beta secretion
Honsho et al., Circ Res 2009
(Endomyocardial Fibrosis...) :
IL-1beta deficiency markedly
increased c-Jun N-terminal kinase (JNK) and
caspase-3 activities and enhanced myocyte apoptosis and fibrosis, whereas replacement of IGF-1 or JNK inhibitor restored them
Henrotin et al., Osteoarthritis Cartilage 2010
(Inflammation...) :
Curcumin blocks
IL-1beta induced proteoglycan degradation, AP-1/NF-kappaB signalling, chondrocyte apoptosis and activation of
caspase-3
Li et al., Pain 2009
(Complex Regional Pain Syndromes...) :
Using this model we observed that : ( 1 ) inflammasome components and products NALP1, caspase-1, IL-1beta and IL-18 were present in low levels in normal skin, but expression of all these was strongly up-regulated after fracture, ( 2 ) NALP1, caspase-1 and
IL-1beta were co-expressed in keratinocytes, and the number of NALP1,
caspase-1 , and IL-1beta positive cells dramatically
increased at 4 weeks post-fracture, ( 3 ) LY303870, an NK1 receptor antagonist, effectively blocked fracture induced up-regulation of activated inflammasome components and cytokines, ( 4 ) IL-1beta and IL-18 intraplantar injection induced mechanical allodynia in normal rats, and ( 5 ) both a selective caspase-1 inhibitor and an IL-1 receptor antagonist attenuated fracture induced hindpaw mechanical allodynia
Clarke et al., Circ Res 2010
(Hyperlipidemias...) :
In contrast, secondary necrotic VSMCs release both IL-1alpha and
caspase activated
IL-1beta , augmenting IL-6 and MCP-1 production
Guma et al., Arthritis Rheum 2009
(Arthritis, Experimental...) :
The production of
IL-1beta by neutrophils and mast cells is not exclusively
dependent on
caspase 1, and other proteases can compensate for the loss of caspase 1 in vivo
Auerbuch et al., PLoS Pathog 2009
(Yersinia pseudotuberculosis Infections) :
However,
caspase-1 was
required for secretion of the inflammatory cytokine
IL-1beta in response to T3SS positive Y. pseudotuberculosis
Meixenberger et al., J Immunol 2010
:
RNA interference and inhibitor experiments in human PBMCs as well as experiments in Nlrp3 and Rip2 knockout bone marrow derived macrophages demonstrated that the Listeria induced
IL-1beta release was
dependent on ASC,
caspase-1 , and NLRP3, whereas NOD2, Rip2, NLRP1, NLRP6, NLRP12, NLRC4, and AIM2 appeared to be dispensable
Imamura et al., J Immunol 2010
(Shock, Septic) :
Interestingly, the NOD of human PYNOD was sufficient to inhibit caspase-1 mediated IL-1beta secretion, whereas its pyrin domain was sufficient to inhibit ASC mediated NF-kappaB activation and apoptosis and to reduce ASC 's ability to promote
caspase-1 mediated
IL-1beta production
Bauer et al., Gut 2010
(Colitis...) :
Macrophages incubated with DSS in vitro secreted high levels of
IL-1beta in a
caspase-1 dependent manner
Dinarello et al., Expert Rev Clin Immunol 2005
:
IL-18 is a member of the IL-1 family ;
IL-1beta and IL-18 are closely related, and both
require the intracellular cysteine protease
caspase-1 for biologic activity
Zitta et al., Biochem Biophys Res Commun 2010
(Myocardial Infarction) :
Gene expression of
caspase-3 was
increased by
IL-1beta ( P < 0.05 vs. control ; 100ng/ml ; 3h ), and pro-caspase-3 but not active caspase was detected in lysates of pig heart cells by Western blotting
Kotrange et al., J Leukoc Biol 2011
(Burkholderia Infections) :
Burkholderia cenocepacia O polysaccharide chain contributes to
caspase-1 dependent
IL-1beta production in macrophages
Ghayur et al., Nature 1997
:
A selective
caspase-1 inhibitor
blocks both lipopolysaccharide induced
IL-1beta and IFN-gamma production from human mononuclear cells
Schumann et al., Blood 1998
:
Taken together, these results show that LPS moderately activates caspase-1 and that
caspase-1 activation
contributes to LPS induction of
IL-1 beta secretion
Johnson et al., Gene 1998
:
However, the pattern of mRNA expression is consistent with a requirement for
caspase-1 mediated
IL-1beta production in chicken immune tissues