◀ Back to IFNG

IFNG — IL1B

Text-mined interactions from Literome

Huang et al., Changgeng yi xue za zhi / Changgeng ji nian yi yuan = Chang Gung medical journal / Chang Gung Memorial Hospital 1999 : The spontaneous or IFN-gamma +TNF-alpha +IL-1 beta induced IL-8 release was significantly augmented after the addition of neutrophils
Reznikov et al., Proc Natl Acad Sci U S A 2000 : Consistent with these observations, IL-12, a known inducer of IFN-gamma, augmented IL-1beta induced IFN-gamma but suppressed IL-1beta induced PGE ( 2 ) by 75 %
Zhao et al., Int J Mol Med 2000 : Similarly, IL-6 and IFN-gamma potently enhanced IL-1beta- or TNF-alpha induced C3 and factor B secretion, respectively
Heitmeier et al., J Biol Chem 2001 (Diabetes Mellitus, Type 1...) : dsRNA and IFN-gamma stimulate IL-1beta expression and ICE activation in primary beta-cells, respectively
Laurent et al., Infect Immun 2001 (Coccidiosis) : Moreover, in the chicken macrophage cell line HD-11, CC chemokines, MGF, IL-1beta , and iNOS were inducible by IFN-gamma , suggesting that macrophages may be one of the cell populations involved in the upregulation of these cytokines observed in vivo during infection with Eimeria
Robson et al., J Immunol 2001 : In contrast, IFN-gamma inhibited basal and IL-1beta- , and TNF-alpha induced production of IL-8
Guedez et al., Arthritis Rheum 2001 (Arthritis...) : Endogenous IFNgamma plays a role in the regulation of IL-1beta , in this model of autoimmune arthritis
Klegeris et al., Neurosci Lett 2001 (Neuroblastoma) : LPS+IFN-gamma stimulation increased IL-1beta secretion 16-fold from THP-1 cells
Teng et al., Am J Physiol Cell Physiol 2002 : In rat aortic smooth muscle cells ( RASMC ), interferon (IFN)-gamma enhanced nitrite accumulation and type II nitric oxide synthase (iNOS) protein expression induced by interleukin (IL)-1 beta
Choi et al., J Neurosci Res 2002 : Zaprinast also enhanced NO production induced by LPS or IFN-gamma ( 100 U/ml ), and in microglial cell cultures, but not in astrocyte cultures, zaprinast enhanced the basal and the IFN-gamma induced production of the cytokines, TNF-alpha and IL-1beta , and of NO
Wuyts et al., Lab Invest 2003 : The CXC chemokine GCP-2/CXCL6 is predominantly induced in mesenchymal cells by interleukin-1beta and is down-regulated by interferon-gamma : comparison with interleukin-8/CXCL8
Rendon-Mitchell et al., J Immunol 2003 : IFN-gamma , an immunoregulatory cytokine known to mediate the innate immune response, dose-dependently induced the release of HMGB1, TNF, and NO, but not other cytokines such as IL-1alpha, IL-1beta , or IL-6
Augstein et al., Biochem Biophys Res Commun 2003 (Diabetes Mellitus, Type 1) : To investigate whether TGZ acts by affecting the ICAM-1/LFA-1 pathway and/or the Th1/Th2 cytokine balance in NOD mice, we analysed the IL-1beta induced ICAM-1 expression on islet-cells and the LFA-1, CD25, IL-2, IFN-gamma , IL-4, and IL-10 expression on splenocytes
Nakamaki et al., Anticancer Res 1992 (Leukemia, Promyelocytic, Acute) : GM-CSF as well as D3 and IFN-gamma induced interleukin-1 beta (IL-1 beta) production by the HL-60 cells, clearly indicating their importance in differentiation of these cells
Peters et al., Immunology 2003 : Mitogen stimulation of embryonic day 18 and day 1 post-hatch thymocytes induced up-regulation of IFN-gamma , IL-1beta and TGF-beta transcripts, and down-regulation of IFN-alpha, IFN-beta and IL-2 transcripts, with a higher induction of IFN-gamma, IL-1beta and TGF-beta transcripts in more immature T-cell-receptor negative ( TCR- ) than TCR+ ( TCR1+, TCR2+, or TCR3+ ) subsets
Vey et al., J Immunol 1992 : In THP-1 cells, IFN-gamma induces cell surface expression of HLA-DR and CD54 and production of IL-1 beta , TNF-alpha, and IL-6
Pannu et al., J Neurosci 2004 (Demyelinating Diseases...) : Silencing of GalT-2 gene with the use of antisense oligonucleotides resulted in decreased LPS/IFN-gamma induced iNOS, TNF-alpha, and IL-1beta gene expression
Stoffels et al., J Autoimmun 2004 (Necrosis) : In contrast, NOD macrophages failed to up-regulate IL1beta and IL12p40 in response to IFNgamma
Dai et al., Ann Rheum Dis 2004 (Arthritis, Rheumatoid...) : IL18, IL1 beta , and TNF alpha did not induce M-CSF, GM-CSF, IFN gamma , or OPG production in PHA prestimulated T cells or RA synovial T cells
Shinozawa et al., Nihon rinsho. Japanese journal of clinical medicine 2004 (Disseminated Intravascular Coagulation...) : TNF augments inflammation, TNF and IFN-gamma induce coagulation, and IL-1beta induces coagulation and fibrinolysis
Nakahara et al., Clin Exp Immunol 2005 (Neoplasms) : Furthermore, IFN-gamma + IL-1beta treated DCs produced larger amounts of IL-12 and induced stronger T cell proliferation and IFN-gamma secretion in primary allogeneic mixed lymphocyte reaction (MLR) than did TNF-alpha treated DCs
Omari et al., Brain 2005 (Hypertrophy...) : CXCL8 and CXCL1 production by human astrocytes at both the RNA and protein levels could be induced by interleukin (IL)-1beta , while CXCL10 was induced by both IL-1beta and interferon-gamma
Jensen et al., J Endocrinol 2005 : Gel retardation experiments showed that hGH affects neither IFN-gamma+TNF-alpha induced STAT1 DNA binding nor IL-1beta and IFN-gamma+TNF-alpha induced NFkappaB DNA binding
Saud et al., Neurotox Res 2005 : In hippocampal cultures exposed to LPS+IFN-gamma, TGF-beta1 was induced whereas in microglial cell cultures LPS+IFN-gamma induced the secretion of IL-1beta
Tsung et al., Am J Physiol Gastrointest Liver Physiol 2006 (Reperfusion Injury) : Whereas IFN-gamma and IFN-beta were strong inducers of IRF-1 mRNA ( > 10-fold ) in a time- and dose dependent manner, TNF-alpha and IL-1beta also induced IRF-1 mRNA to a lesser extent ( 2- to 3-fold )
Shirey et al., J Interferon Cytokine Res 2006 : Furthermore, increases in IFN-gamma receptors (IFNGR) induced by IL-1beta were found to be dependent on NF-kappaB transactivation
Pirot et al., Diabetologia 2006 : IL-1beta alone induced endoplasmic reticulum stress but failed to induce beta cell death, while IFN-gamma alone neither caused endoplasmic reticulum stress nor induced beta cell death
Puliti et al., Microbes Infect 2006 (Arthritis...) : The worsening of sepsis and arthritis was associated with a significant increase in systemic and local production of IL-6, IL-1 beta , TNF-alpha, IL-10, macrophage inflammatory protein 1 alpha ( MIP-1alpha ), and MIP-2 and with a decrease in IFN-gamma production
Doukas et al., J Immunol 1990 : In our study, we have further examined IFN-gamma effects on both TNF and IL-1 beta responses
Xia et al., Reprod Fertil Dev 2007 : The IFN-gamma induced expression of interleukin (IL)-1beta was examined using western blotting, immunohistochemistry and immunofluorescence ... These results indicate that exogenous IFN-gamma affects the expression of IL-1beta and inhibits ESC proliferation
Wang et al., J Immunol 2007 : Recombinant trout IL-15 preferentially stimulated splenic leukocytes from healthy fish, where it induced a large increase in IFN-gamma expression, with little, if any, effect on IL-1 beta expression
Hirota et al., J Exp Med 2007 (Arthritis, Experimental...) : The CCL20 production by synoviocytes is augmented in vitro by IL-1beta , IL-17, or tumor necrosis factor alpha, and is suppressed by IFN-gamma or IL-4
Kim et al., Phytomedicine 2008 (Arthritis, Experimental) : As compared with rats treated with saline, BVA i.p. injected at doses of more than 20 microl/100g mouse once a day for 14 days inhibited the ability of inguinal lymph node cells to produce T cell cytokines interleukin-1beta , -2, -6, tumor necrosis factor-alpha and interferon-gamma when the cells were obtained from rats 24 days after immunization and cultured in vitro with CII
Mathieu et al., Eur J Immunol 2008 (Arthritis, Rheumatoid) : The mutually antagonistic relationship between IFN-gamma and PGE ( 2 ) extends to downstream cytokine and chemokine release ; PGE ( 2 ) counters the effects of IFN-gamma , on the release of IP-10, IL-8, TNF-alpha and IL-1beta
Nareika et al., Atherosclerosis 2009 (Atherosclerosis...) : Results showed that high glucose and IFN gamma had a synergistic effect on the expression of MMP-1, MMP-9 and IL-1 beta
Raices et al., Cytokine 2008 : A synergistic role for IL-1beta and TNFalpha in monocyte derived IFNgamma inducing activity ... Moreover, size-fractionation of the monocyte conditioned media dramatically reduced the IFNgamma inducing activity of IL-1beta , suggesting that IL-1beta requires a cofactor to induce IFNgamma production in KG-1 cells ... Furthermore, rTNFalpha restored the IFNgamma inducing activity of the size fractionated IL-1beta
Fitzner et al., Pancreatology 2009 (Autoimmune Diseases...) : IFN-gamma also caused pancreatic accumulation of CD4-, CD8-, C11b- and CD138 positive cells, and enhanced pancreatic mRNA expression of interleukin (IL)-1 beta , transforming growth factor-beta and IFN-gamma itself
Halme et al., Mol Immunol 2009 (Hepatitis) : The expression of CD59 could be augmented by IL-1 beta , IL-6 and TNF-alpha but was suppressed by IFN-gamma
Guo et al., Proc Natl Acad Sci U S A 2009 : Similarly, Th17 cells produce IL-17A in response to IL-1beta and a STAT3 activator and Th1 cells produce IFNgamma in response to IL-18 and a STAT4 inducer
Martin-Cordero et al., Eur J Appl Physiol 2009 (Disease Models, Animal...) : The results indicated that : ( 1 ) circulating levels and constitutive production of IL-1beta by macrophages are deregulated in rats with MS, and ( 2 ) IL-1beta and IFNgamma production by macrophages in response to antigenic stimulus ( LPS ) is impaired in the obese animals, and this MS-associated disorder is improved by the program of habitual exercise training
Raices et al., PloS one 2009 : NFkappaB inhibition resulted in decreased IL-1beta/IL-18/TNFalpha stimulated IFNgamma release
Shultz et al., J Interferon Cytokine Res 2009 : IFN-gamma does not affect the transient activation of classical NF-kappaB by IL-1beta and synergistic induction of ip-10 expression by IFN-gamma and IL-1beta occurs even after the activation of classical NF-kappaB has returned to basal levels
van de Wetering et al., PloS one 2009 (Salmonella Infections) : Supernatants of Salmonella infected Mphi1 contained more IL-18 and IL-1beta as compared with supernatants of Mphi1 stimulated with isolated TLR agonists, and induced IFN-gamma production in human CD56 ( + ) cells in an IL-23 and IL-1beta dependent but IL-12 independent manner
Page et al., Arthritis Res Ther 2010 (Arthritis, Experimental...) : IFN-gamma did not affect IL-1beta induced tissue inhibitor of metalloproteinase-1 ( TIMP-1 ) production by RA FLS but skewed the MMP/TIMP-1 balance sufficiently to attenuate glycosaminoglycan-depletion in our BACE model ... IFN-gamma reduced IL-1beta expression in the arthritic joint and prevented cartilage degeneration on Day 3 of AIA
Wang et al., Exp Cell Res 2010 : Moreover, the inflammatory cytokine IL-1beta , either exogenously added or produced by CD14 ( + ) monocytes in culture, could trigger expression of high levels of PGE ( 2 ) by hUC-MSCs, whereas inclusion of the IL-1 receptor antagonist (IL-1RA) in the culture down-regulated not only PGE ( 2 ) expression, but also reversed the promotional effect of CD14 ( + ) monocytes and partially restored CD4 ( + ) and CD8 ( + ) T cell proliferation and IFN-gamma secretion
Masters et al., EMBO Rep 2010 : Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production ... Reports describing the effect of interferon-gamma (IFNgamma) on interleukin-1beta (IL-1beta) production are conflicting ... In human cells, IFNgamma increased IL-1beta production, and this might explain why IFNgamma is detrimental for multiple sclerosis
Gaffney et al., J Biol Response Mod 1990 (Leukemia, Monocytic, Acute) : Recombinant interferon-gamma ( rIFN gamma ) alone did not induce IL-1 beta secretion and did not significantly increase secretion by LPS- and silica stimulated cells ... The role of IFN gamma in stimulating IL-1 beta secretion was not related to an enhancement of viability or an increase in the proportion of mezerein treated cells synthesizing DNA
te Velde et al., Blood 1990 : To elucidate which cytokines produced by monocytes are controlled by IL-4, we tested the effect of IL-4 on the secretion of IL-1 alpha, IL-1 beta , TNF alpha, and IL-6 induced by LPS or IFN gamma
Herrmann et al., J Immunol 1989 : Induction of IL-1 beta secretion by IFN gamma and IL-2
Ruschen et al., Clin Exp Immunol 1989 (Arthritis, Rheumatoid) : Interferon-gamma (IFN-gamma) significantly inhibited the spontaneous intracellular IL-1 beta production in SFM phi 12-h cultures of RA patients
Garrison et al., J Periodontal Res 1989 (Disease Susceptibility...) : Because IFN-gamma can influence LPS stimulated responses, the effect of IFN-gamma on the LPS stimulated release of PGE2 and IL-1 beta was also assessed ... IFN-gamma did not affect the LPS stimulated release of PGE2 but significantly enhanced the release of IL-1 beta
Szefler et al., J Immunol 1989 : IFN-gamma did not cause monocytes to secrete IL-1 beta or TNF-alpha, under our culture conditions ( mononuclear cells cultured in Teflon in endotoxin-free modified Earle 's salt solution without serum )
Ghezzi et al., J Immunol 1988 : IFN-gamma inhibited IL-1 beta induced IL-1 alpha as well as IL-1 alpha induced IL-1 beta production ; furthermore, this inhibitory effect of IFN-gamma was unaffected by indomethacin
Koide et al., Hypertension 1994 : These findings suggest that interferon gamma directly induces the expression of the inducible nitric oxide synthase gene, whereas tumor necrosis factor-alpha and interleukin-1 beta induce it, at least in part, via the induction of intermediary protein ( s ), and that transforming growth factor-beta 1 inhibits cytokine induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase
Cassatella et al., Biochem J 1995 : However, nuclear run-on analysis revealed that LPS increased the transcription of the IL-8 and IL-1 beta genes and that, in LPS activated cells, IFN gamma markedly inhibited the rate of IL-8 gene transcription, but not that of IL-1 beta
Kimball et al., J Leukoc Biol 1995 (Leukemia, Monocytic, Acute) : Northern blotting studies revealed no effect of IFN-gamma alone on IL-1 beta or TNF-alpha mRNA production
Bourdoulous et al., J Immunol 1995 (Heartwater Disease) : Infection induced the production of IL-1 beta , -6, and -8 mRNAs, and this effect was potentiated by IFN-gamma
Panja et al., Clin Exp Immunol 1995 : LPS, IFN-gamma or TNF-alpha had no effect on spontaneous IL-6 production, and neither resulted in the secretion of IL-1 beta or TNF-alpha
Chen et al., Hokkaido Igaku Zasshi 1994 : In addition, the effects of IFN-gamma on ISO relaxation and IL-1 beta on KCl contraction were abolished by indomethacin but not by N omega-nitro-L-arginine methyl ester ( N omega-NAME )
Porrini et al., Cell Immunol 1994 (Multiple Sclerosis) : Spontaneous and IFN-gamma induced IL-1 beta secretion was greater in MS than in NL Mo. IFN-beta did not inhibit IFN-gamma induced secretion of monokines, which contrasts with IFN-beta 's inhibitory effect on IFN-gamma induced MHC class II expression
Meda et al., Cell Immunol 1994 : Unlike IL-8, the LPS stimulated production of TNF and IL-1 beta , as well as the TNF stimulated production of IL-1 beta, was markedly enhanced by IFN-gamma over the entire incubation period ( up to 18 hr )
Quiding et al., Clin Exp Immunol 1993 : Furthermore, IL-1 beta synergized with IL-2 by increasing intracellular as well as cell-free levels of IFN-gamma in cultures of unfractionated tonsillar MNC
D'Andrea et al., J Exp Med 1993 : Our findings that antibodies against NKSF/IL-12, TNF-alpha, or IL-1 beta can significantly inhibit IFN-gamma production in response to various stimuli and that NKSF/IL-12 and IL-1 beta can overcome the IL-10 mediated inhibition of IFN-gamma, suggest that IL-10 inhibition of IFN-gamma production is primarily due to its blocking production from accessory cells of the IFN-gamma-inducer NKSF/IL-12, as well as the costimulating molecule IL-1 beta
Dignass et al., Gastroenterology 1993 : The restitution promoting cytokines TGF-alpha, EGF, IL-1 beta , and IFN-gamma increase the production of bioactive TGF-beta 1 peptide in wounded IEC-6 cell monolayer
Hauer et al., Cancer Immunol Immunother 1993 : Generally, arabinogalactan pretreatment induced an increased release of interferon gamma (IFN gamma), tumor necrosis factor alpha, interleukin-1 beta (IL-1 beta) and IL-6 but only IFN gamma was involved in enhancement of NK cytotoxicity since cytotoxicity enhancement of PBMC and PNAC but not that of monocytes could be blocked when anti-IFN gamma antibodies were present during pretreatment
Hahn et al., J Clin Invest 1993 (Arthritis, Rheumatoid) : In particular, IL-1 beta and neopterin production were further enhanced by stimulation with either interferon-gamma (IFN-gamma) or TNF-alpha without a synergistic effect
Chujor et al., Eur J Immunol 1996 : In the present study, we have examined the effect of interferon (IFN)-gamma on the expression of the IL-1 beta gene in mouse RAW 264.7 macrophages activated by lipopolysaccharide (LPS) plus tumor necrosis factor (TNF)-alpha
Loughlin et al., Neurochem Int 1996 : Inhibitory effect of interferon-gamma on LPS induced interleukin 1 beta production by isolated adult rat brain microglia
Arena et al., New Microbiol 1996 : Role of IFN gamma on TNF alpha, IL-1 beta and IL-6 release during HHV-6 infection
Wong et al., Immunol Cell Biol 1996 : While beta-casein had no significant effects on IFN gamma production by ovine blood lymphocytes, and TNF alpha production and MCH Class II antigen expression by ovine bronchoalveolar macrophages, it enhanced IL-1 beta production by the macrophages, beta-casein also had no influence on bovine NK cell activity against a virally infected cell line
Bruserud et al., Cancer Immunol Immunother 1996 (Leukemia, Myeloid, Acute) : Exogenous IL-1 beta , IL-2 and IL-7 increased allostimulated IFN gamma secretion, whereas decreased levels were seen in the presence of IL-6, IL-10 and granulocyte-colony stimulating factor ( G-CSF )
Elner et al., Invest Ophthalmol Vis Sci 1997 : IFN-gamma induced dose dependent increases in HRPE MCP-1, but not IL-8, IFN-gamma potentiated IL-1 beta and TNF-alpha induced MCP-1 production, but showed little modulation of IL-1 beta and TNF-alpha induced IL-8 production
Bai et al., J Neuroimmunol 1997 (Neuritis, Autoimmune, Experimental) : Macrophages from Linomide treated EAN rats showed decreased IL-1 beta , TNF-alpha and IL-6 mRNA expression in response to IFN-gamma and LPS
Sumiyoshi et al., J Gastroenterol 1997 (Pancreatic Neoplasms) : The secretion of C4 and factor B in ductal cell lines ( PANC-1 and MIA PaCa-2 ) was independently regulated by interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma ; C4 secretion was induced by IFN-gamma , whereas factor B secretion was induced by IL-1 beta , TNF-alpha, or IFN-gamma
Harding et al., Biochim Biophys Acta 1996 : Quantitative reverse transcription-polymerase chain reaction indicated that the m-RNA level was not increased by interferon-gamma but was synergistically increased by interferon-gamma plus interleukin-1beta
Hauber et al., Cell Immunol 1997 : We show that gene expression of IL-1 alpha, IL-1 beta , IL-6, granulocyte-colony stimulating factor, and IL-10 was induced in both cell fractions, whereas increased mRNA levels of interferon-gamma and the inducible nitric oxide synthase were exclusively detected in the patients ' nonadherent MNCs
Hunter et al., Eur J Immunol 1997 : Comparison of the effects of interleukin-1 alpha, interleukin-1 beta and interferon-gamma inducing factor on the production of interferon-gamma by natural killer ... In contrast to IL-12 and IL-2, the ability of IGIF to stimulate NK cell production of IFN-gamma was not increased by IL-1 alpha or IL-1 beta
Schroeder et al., Hepatology 1998 : In a system of rat hepatocytes in primary culture, IL-1beta induced production of both NO and IFN-gamma ... Inhibition of NO synthesis using the competitive substrate inhibitor N-monomethyl-L-arginine ( 100 micromol/L ) did not alter the extent of IL-1beta mediated IFN-gamma synthesis
Gasperini et al., AIDS 1998 (HIV Infections) : In contrast, release of IL-1beta and IL-1ra ( IL-1 receptor antagonist ) in response to LPS, or LPS plus IFNgamma , was found to be lower in PMN from HIV positive patients than in PMN from controls, but was significant only in the case of IL-1ra
Li et al., Immunopharmacol Immunotoxicol 1998 : These findings appear to suggest that PLD derived phosphatidate is not the primary source of DAG production in IFN-gamma induced TNF-alpha secretion, but may be necessary for IFN-gamma mediated MHC class II induction and IL-1 beta production in human monocytes, whereas phospholipase A2 may not be required for IFN-gamma activation of PKC in the process
Southey et al., Int J Immunopharmacol 1997 (Colitis) : Lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) stimulated release of nitrite, lactate dehydrogenase ( LDH ), TNF alpha, IL-1 beta and IL-8 from rat peritoneal macrophages, all of which were significantly reduced by ITU
Arnush et al., J Clin Invest 1998 : Reverse transcriptase polymerase chain reaction was used to confirm that TNF + LPS + IFN-gamma stimulates the expression of both IL-1alpha and IL-1beta in human islets
Liu et al., J Immunol 1998 : Like IFN-beta, IFN-gamma suppresses the expression of both LPS and IL-1 induced IL-1beta
Rohn et al., J Immunol 1999 (Astrocytoma) : IL-1beta suppressed IFN-gamma activation of the type IV CIITA promoter in astroglioma cells, indicating that the inhibitory influence of IL-1beta is mediated by inhibition of CIITA transcription