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EGFR — INS

Pathways - manually collected, often from reviews:

• KEGG Prostate cancer: EGF/IGF1/INS/PDGFA/PDGFB/PDGFC/PDGFD/TGFA → EGFR/ERBB2/FGFR1/FGFR2/IGF1R/INSRR/PDGFRA/PDGFRB (protein-protein, activation)
  
• WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16 → FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK (activation)
  

Text-mined interactions from Literome

Santiskulvong et al., Biochem Biophys Res Commun 2004 : Insulin reduces the requirement for EGFR transactivation in bombesin induced DNA synthesis
Chong et al., Biochem Biophys Res Commun 2004 : EGFR transactivation by insulin was not observed
Lyu et al., Molecular vision 2006 : Inhibition of EGFR activation by AG1478 or the MMP inhibitor, GM6001, reduced phosphorylation of insulin induced ERK in the presence of insulin and delayed wound closure
Roztocil et al., Surgery 2008 : Insulin induced time dependent EGFR phosphorylation, which was inhibited by AG1478 in a concentration dependent manner
Reinehr et al., J Biol Chem 2010 (Hepatomegaly) : Insulin induces swelling dependent activation of the epidermal growth factor receptor in rat liver ... Insulin ( 35 nmol/liter ) induced phosphorylation of the EGFR at position Tyr ( 845 ) and Tyr ( 1173 ), but not at Tyr ( 1045 ), suggesting that EGF is not involved in insulin induced EGFR activation ... Insulin induced EGFR phosphorylation and subsequent ERK1/2 phosphorylation were sensitive to bumetanide, indicating an involvement of insulin induced hepatocyte swelling ... As shown by immunoprecipitation studies, insulin and hypoosmolarity induced a rapid, RGD peptide-, integrin beta1 blocking antibody and PP-2-sensitive association of c-Src with the EGFR ... It is concluded that insulin- or hypoosmolarity induced hepatocyte swelling triggers an integrin- and c-Src kinase dependent EGFR activation, which may explain the proliferative effects of insulin
Oleksiewicz et al., J Appl Toxicol 2011 : By western blotting with phospho-specific antibodies, insulin induced phosphorylation of IRS-1, Akt, p70S6K, S6 ribosomal protein, 4E-BP1, FoxO3a, FoxO1, p44/42 MAPK and the EGFR
Hörndler et al., Cancer Biol Ther 2011 (Colorectal Neoplasms) : By transactivacion, phosphorylated insulin growth factor receptor I ( IGF-1R ) can activate epidermal growth factor receptor (EGFR)
Sharma et al., Endocrinology 2011 : Insulin secretion in response to estradiol and G-1 was dependent on epidermal growth factor receptor and ERK activation and further modulated by phosphatidylinositol 3-kinase activity ... Our results indicate that GPER activation of the epidermal growth factor receptor and ERK in response to estradiol treatment plays a critical role in the secretion of insulin from ß-cells
Gupta et al., Hypertension 2012 (Disease Models, Animal...) : Either ouabain or insulin alone caused accumulation of and carcinoembryonic antigen cell adhesion molecule, as well as insulin receptor-ß, and epidermal growth factor receptor in early endosomes, but no synergy was demonstrable
Hahn et al., J Cell Sci 2013 (MAP Kinase Signaling System) : We further demonstrate that step transcription is induced by EGFR signaling whereas it is negatively regulated by insulin signaling
Riedel et al., Nature 1986 : A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor
Vardy et al., J Cell Physiol 1995 : Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1