Gene interactions and pathways from curated databases and text-mining

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CASP4 — LMNB2

Text-mined interactions from Literome

Wang et al., Neuroreport 1999 (Huntington Disease...) : The cleavage of lamin B was inhibited by caspase inhibitors
Gotzmann et al., J Cell Sci 2000 : Using various cell systems, including Jurkat, HL-60, and HeLa cells, and different death inducing agents, such as anti-Fas antibody, topoisomerase inhibitors, and staurosporine, we found that LAP2 alpha was cleaved during apoptosis as rapidly as lamin B in a caspase dependent manner yielding stable N- and C-terminal fragments of approximately 50 and 28 kDa, respectively
Zhang et al., Proc Natl Acad Sci U S A 2001 : Both GzmA and GzmB directly and efficiently cleave laminB in vitro, in situ in isolated nuclei and in cells loaded with perforin and Gzms, even in the presence of caspase inhibitors
Taimen et al., J Cell Sci 2003 : The cleavage of NuMA, lamin B and PARP-1 was inhibited in the presence of three different caspase inhibitors : z-DEVD-FMK, z-VEID-FMK and z-IETD-FMK
Almaguel et al., J Neurosci Res 2009 : The observed cell death was apoptotic based on nuclear morphology, caspase-3 activation , and cleavage of lamin B and PARP