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MAPK8 — SETD2

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Richard et al., J Biol Chem 1999 (Anoxia) : Finally, we found that in a vascular endothelial growth factor promoter mutated at sites previously shown to be MAPK-sensitive ( SP1/AP2-88-66 site ), p42/p44 MAPK activation is sufficient to promote the transcriptional activity of HIF-1
Tacchini et al., Carcinogenesis 2001 (Carcinoma, Hepatocellular...) : Third, consistent with these data, N-acetylcysteine reduced the stimulatory effect of HGF on stress kinase activities, while p42/44 mitogen activated kinase ( MAPK ) was unmodified, suggesting an involvement of c-Jun-N-terminal kinase (JNK) and p38 MAPK in HIF-1 activation
Hofer et al., FASEB J 2001 : Because overexpressed HIF-1a is fully localized to the nucleus but displays only partial DNA binding and trans-activation activity, mitogen activated protein kinase dependent phosphorylation might be required for full HIF-1 activation
Fradette et al., Curr Drug Metab 2004 (Anoxia...) : The up-regulation of CYP3A6 implies a PTK- and p42/44MAPK dependent stabilization/activation, nuclear translocation of HIF-1 and AP-1, binding to CYP3A6 promoter, and transactivation of the gene to induce CYP3A6 expression
Emerling et al., Mol Cell Biol 2005 (Anoxia) : These results provide genetic evidence that p38 mitogen activated protein kinase signaling is essential for HIF-1 activation
Trisciuoglio et al., Mol Biol Cell 2005 (MAP Kinase Signaling System...) : Pharmacological inhibition of mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3-kinase (PI3K) signaling pathways reduced the induction of VEGF and HIF-1 in response to bcl-2 overexpression in hypoxia
Sutton et al., Oncogene 2007 : Here, we investigated the involvement of the mitogen activated protein kinase ( MAPK ) signalling pathway in HIF-1 regulation
Liu et al., Mol Biol (Mosk) 2008 (Anoxia...) : PI3K and MAPK inhibitor, LY294002 and U0126 could inhibit hypoxia induced HIF-1 and VEGF expression
Nys et al., J Invest Dermatol 2010 (Carcinoma, Squamous Cell...) : Furthermore, p38 ( MAPK ) was required for the induction and activation of hypoxia-inducible factor 1 (HIF-1) in response to UVB, and HIF-1 knockdown reduced Noxa expression and apoptosis
Zhang et al., Oncogene 2010 (Carcinoma, Renal Cell...) : RKTG, by suppressing mitogen activated protein kinase signaling, negatively regulates the transactivation activity of hypoxia-inducible factor 1a (HIF-1a) by inhibiting formation of HIF-1a/p300 complex and suppressing VEGF transcription, thereby reducing hypoxia induced VEGF production
Lim et al., Environ Toxicol Chem 2012 : The results also suggest that GST and HIF-1 activation by AgNP exposure are PMK-1 p38 MAPK dependent , and that both play an important role in the PMK-1 p38 MAPK mediated defense pathway to AgNP exposure in C. elegans
Cheng et al., Cancer Lett 2013 (Ovarian Neoplasms) : However, the induction of HIF-1a by EGF did not require the activation of p38 MAPK
Paweł et al., Lipids 2013 (Leiomyoma...) : Additionally, in uterine leiomyomas we found relevant activation of both PTEN and MAPK(ERK1/2) signaling pathways with only a minor change in AKT activity and relatively absent HIF-1a/AMPK activation