Gene interactions and pathways from curated databases and text-mining

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MET — PRKAG2

Text-mined interactions from Literome

Turban et al., J Biol Chem 2012 : Expression of a constitutively active AMPK mimicked the effects of AICAR on GU, whereas a dominant interfering AMPK or shRNA silencing of AMPK prevented AICAR stimulated GU and Met induced AMPK signaling but only repressed biguanide stimulated GU by ~20 % ... Our findings indicate that although Met activates AMPK , a significant component of Met stimulated GU in muscle cells is mediated via an AMPK independent mechanism that involves novel/conventional PKCs
Storozhuk et al., Br J Cancer 2013 (Carcinoma, Non-Small-Cell Lung...) : Ionising radiation and MET induced ( i ) sustained activation of ATM-AMPK-p53/p21 ( cip1 ) and inhibition of Akt-mTOR-4EBP1 pathways in tumours, ( ii ) reduced expression of angiogenesis and ( iii ) enhanced expression of apoptosis markers.Conclusion : Clinically achievable MET doses inhibit NSCLC cell and tumour growth and sensitise them to IR