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IRF6 — MPO

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Liu et al., Mol Pharmacol 1999 (Shock, Septic) : Pyrrolidine dithiocarbamate also markedly reduced the LPS induced tissue myeloperoxidase activity ( an indicator of tissue neutrophil retention ) and the LPS induced increase in microvascular permeability in these organs
Jaovisidha et al., J Immunol 1999 : In contrast, LPS induced only chemokine but not MPO release
Sheridan et al., Am J Physiol 1999 (Pneumonia) : Similarly, TNF-alpha binding protein ( 175 mg/kg ) attenuated LPS induced myeloperoxidase activity ( 6.04 +/- 0.14 U/g lung wet wt ; P < 0.05 )
Olszanecki et al., J Physiol Pharmacol 1999 (Endotoxemia) : However, LPS induced increase in pulmonary MPO activity was seen at both time intervals
Squadrito et al., Life Sci 1999 (Acute Disease...) : Sulfatide treatment ( 10 mg/kg, 30 min. after LPS challenge ), significantly protected against LPS induced lethality ( 90 % survival rate and 70 % survival rate 24 h and 72 h after LPS injection ), reduced LPS induced hypotension, reverted leukopenia ( 8,895+/-234 cells/ml ) and lowered lung MPO activity ( 1.7+/-0.9 U/g/tissue )
Allcock et al., Clin Exp Immunol 2001 (Endotoxemia) : DEX attenuated the LPS induced increase in MPO in the ileum but had no effect on MPO in the lungs or kidneys ... ANX-1 had no effect on the LPS induced increase in MPO activity in any of the tissues studied
Gluckman et al., J Endotoxin Res 2002 (Disease Models, Animal...) : S-NO-alb did not, however, attenuate LPS induced increases in lung MPO
Witzenbichler et al., Circulation 2005 (Pulmonary Edema...) : In addition, LPS induced increase in lung water content and pulmonary myeloperoxidase activity was significantly reduced
Chu et al., Chest 2005 (Lung Diseases) : Normothermia plus LPS caused significantly increased W/D ratio, LDH activities, protein concentrations, and tumor necrosis factor-alpha concentrations in BAL fluid, and MPO activities and MDA levels in lung tissues when compared to saline solution control group
Yilmaz et al., Curr Eye Res 2005 (Disease Models, Animal...) : CAPE significantly suppressed LPS induced increase in the number of inflammatory cells ( p = 0.0001 ), protein concentration ( p = 0.0001 ), and MPO levels ( p = 0.0001 ) in aqueous humor as well as MDA ( p = 0.001 ) and MPO ( p = 0.0001 ) levels in serum
Mei et al., Postgrad Med J 2005 (Colitis) : The stimulation of LPS increased the level of NO and MPO and MDA in the co-culture model of inflamed colon mucosa, and melatonin significantly reduced the level of MPO , MDA, and NO
Anuar et al., Br J Pharmacol 2006 (Shock, Septic) : Nitroflurbiprofen ( 3-30 mg kg ( -1 ), i.p. ) administration resulted in a dose dependent inhibition of the LPS mediated increase in plasma TNF-alpha, IL-1beta and NO ( x ) concentration, liver H2S synthesis ( 55.00+/-0.95 nmole mg protein ( -1 ), c.f. 62.38+/-0.47 nmole mg protein ( -1 ), n = 5, P < 0.05 ), CSE mRNA, iNOS, MPO activity and NF-kappaB activation
Hsieh et al., Clin Rheumatol 2007 : The spontaneous membrane expression of MPO and PR3 on PMN could be significantly increased by lipopolysaccharide (LPS) and TNF-alpha, but not by IL-8 or GRO-alpha
Gomes et al., Eur J Pharmacol 2006 (Stomach Diseases) : LPS reduced dose dependently gastric damage and myeloperoxidase activity induced by indomethacin
Bi et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2006 (Acute Lung Injury...) : LPS markedly induced an increase in leukocyte infiltration, W/D ratio, lung MPO activity, release of TNF-alpha as well as MIP-2 into alveolar space in both lipids and NaCl groups ... Notably, lipid emulsions increased LPS induced MPO activity, but no difference in effects was found in both Lipoven and Clinoleic groups
Xian et al., Sheng Li Xue Bao 2007 (Endotoxemia) : LPS also induced increases in TNF-alpha and H2S contents, LDH and MPO activity in cardiac muscles and myocardial damage
Ueki et al., Journal of bioscience and bioengineering 2007 (Nephritis) : UTI ( 50,000 U/kg ) inhibited LPS induced increases in the serum and renal tissue levels of TNFalpha, as well as the renal tissue levels of CINC-1 and MPO after LPS stimulation
Fan et al., Mol Med 2008 (Endotoxemia...) : LPA injection reduced LPS induced plasma TNF-alpha production ( 69 +/- 6 %, P < 0.05 ) and myeloperoxidase (MPO) activity in lung ( 33 +/- 9 %, P < 0.05 ) as compared to vehicle injection
Yin et al., Int Immunopharmacol 2008 (Acute Lung Injury...) : In the mouse model of LPS induced inflammatory lung injury, intravenous precondition of a single 400 mg/kg dose of FDP resulted in a significant reduction in LPS mediated extravasation of Evans blue dye albumin, bronchoalveolar lavage leucocyte content, and lung tissue myeloperoxidase activity ( reflecting phagocyte infiltration )
Ji et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2008 : In addition, Ang II concentration-dependently elevated MPO activity in RAW264.7 cells ( P < 0.01 ), and LPS also enhanced MPO activity of RAW264.7 cells ( P < 0.01 ), but the TLR4 blocker significantly antagonized the effect of Ang II on MPO activity ( P < 0.01 )
Muñoz et al., Am J Physiol Lung Cell Mol Physiol 2009 (Acute Lung Injury...) : LPS also caused 1 ) reduced transthoracic static compliance, 2 ) lung edema, 3 ) neutrophilic infiltration, and 4 ) increased neutrophil myeloperoxidase activity in pla2g5 ( +/+ ) mice
Hoth et al., J Trauma 2009 (Contusions...) : Injury + LPS showed immune priming observed by lung injury histology and increased bronchoalveolar lavage neutrophilia, lung myeloperoxidase and serum IL-6, CXCL1, and MIP-2 levels when compared with injury + vehicle or LPS alone
Liu et al., Chin Med J (Engl) 2010 (Reperfusion Injury) : After treatment with 2 L/min of 250 ppm CO i.p., the increase of PAF, ICAM-1, MDA, MPO , and cell apoptotic rate induced by LPS was markedly reduced ( P < 0.05 or 0.01 ), and accompanied by ameliorating intestine injury
Liu et al., J Ethnopharmacol 2010 (Acute Lung Injury...) : Taraxacum officinale decreased LPS induced MPO activity and increased SOD activity in the lungs
Helyes et al., Neuropeptides 2010 (Pneumonia) : However, LPS induced histological inflammatory changes ( perivascular/peribronchial oedema, neutrophil infiltration and goblet cell hyperplasia ), MPO activity and TNF-alpha concentration were markedly diminished only in TAC1 ( -/- ) mice
Yin et al., Clin Exp Immunol 2011 (Acute Lung Injury...) : Single intranasal administration of Ad-sST2-Fc led to a profound decrease in LPS induced bronchoalveolar lavage leucocyte exudation and lung tissue myeloperoxidase activity ( reflecting phagocyte infiltration )
Berry et al., Reprod Sci 2011 (Chorioamnionitis) : However, IL-1 blockade with IL-1ra did not decrease intra-amniotic LPS induced increases in pro-inflammatory cytokine mRNAs, numbers of inflammatory cells, myeloperoxidase , or monocyte chemotactic protein-1 expressing cells in the chorioamnion
Nogare et al., J Immunol 1990 : Neither LPS nor dLPS caused release of the primary granule enzymes, myeloperoxidase , and elastase
Vohra et al., Am J Physiol Lung Cell Mol Physiol 2012 (Acute Lung Injury...) : Compared with sham treated controls, pretreatment with dopamine ( 50 mg/kg body wt ) ameliorated LPS mediated edema formation and lowered myeloperoxidase activity, a measure of neutrophil infiltration
Sun et al., Int Immunopharmacol 2012 (Acute Lung Injury...) : In addition, ruscogenin markedly decreased LPS induced myeloperoxidase (MPO) activity and nitrate/nitrite content, and also downregulated expression of tissue factor ( TF ), inducible NO synthase (iNOS) and nuclear factor ( NF ) -?B p-p65 ( Ser 536 ) in the lung tissue at three doses
Tokuda et al., Antioxid Redox Signal 2012 (Inflammation) : H ( 2 ) S breathing attenuated LPS induced increase of plasma ALT activity and NOx levels and lung MPO activity
Wan et al., Phytother Res 2013 : In this study, we provide experimental evidences that AS dose-dependently inhibited lipopolysaccharide (LPS) induced fever and inflammatory response, including serum tumor necrosis factor (TNF)-a and interleukin (IL)-6 production, liver myeloperoxidase (MPO) activity, brain cyclooxygenase-2 (COX-2) protein expression and prostaglandin E2 ( PGE2 ) production
Wu et al., Int J Immunopathol Pharmacol 2012 (Liver Failure, Acute) : In addition, pretreatment mice with PD dose-dependently suppressed tumor necrosis factor-alpha (TNF-alpha) production, myeloperoxidase (MPO) activity, intercellular adhesion molecule-1 ( ICAM-1 ) and endothelial cell adhesion molecule-1 ( ECAM-1 ) expression, caspase-3 activation, and transcription factor nuclear factor-kappa B(NF-kB) activity induced by LPS
Lin et al., Shock 2013 (Acute Lung Injury) : In addition, LPS increased pulmonary tissue wet-to-dry weight ratio and tumor necrosis factor a and interleukin 8 levels in plasma and bronchoalveolar lavage fluid enhanced the expression of E-selectin, intercellular adhesion molecule 1, myeloperoxidase , MMP-2, and MMP-9, whereas it decreased the expression of AQP-1 and AQP-5 in pulmonary tissue, all of which were attenuated by SalB pretreatment
Snyder et al., Am J Obstet Gynecol 2013 (Chorioamnionitis...) : LPS greatly increased the expression of proinflammatory cytokines and myeloperoxidase in leukocytes, while Ureaplasma alone caused modest responses ... Interestingly, 7-day but not 70-day Ureaplasma exposure significantly down-regulated LPS induced proinflammatory cytokines and myeloperoxidase expression in the chorioamnion
Leung et al., Evidence-based complementary and alternative medicine : eCAM 2013 : Furthermore, CPC significantly attenuated LPS induced myeloperoxidase activity, O2 ( - ) formation, expression of inducible nitric oxide synthase, and cyclooxygenase-2 as well as nuclear factor-kappa B ( NF- ? B ) activation in lungs
Chang et al., J Lab Clin Med 1994 : Injection of purified human recombinant TNF ( 2 to 200 micrograms/kg i.v. ) mimicked the effect of LPS on lung MPO activity ... Furthermore, pretreatment of the rats with two different PAF receptor-antagonists, WEB 2086 ( 10 mg/kg IP ) and SRI 63-441 ( 10 mg/kg IP ), failed to block LPS induced ( 1 mg/kg ) increase in lung MPO
Triplett et al., Shock 1996 (Endotoxemia) : SK & F 86002 blocked the LPS induced increase in myeloperoxidase activity, indicating a reduction in pulmonary neutrophil infiltration, but had no effect on systemic leukopenia