Kim et al., J Korean Med Sci 2002
(MAP Kinase Signaling System) :
PD98059 ( MEK/ERK inhibitor ) suppressed IL-1beta mediated MUC2 gene expression and mucin secretion, while SB203580 ( p38 inhibitor ) did not
Alcaide et al., Eur J Immunol 2004
(Chagas Disease) :
Furthermore, AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS, since this mucin also inhibited extracellularly regulated kinase (ERK) and Jun kinase (JNK)activation
Lim et al., American journal of translational research 2009
:
In the present study, we showed that positive regulation of MUC5AC mucin expression by ERK1/2 is dependent on Ras-Raf-1 signaling pathway, whereas the negative regulation of MUC5AC expression by JNK1/2 is dependent on MEKK3 ... Ras-Raf1-ERK1/2 dependent AP-1 activation positively regulates MUC5AC mucin induction by S. pneumoniae, whereas MEKK3-JNK1/2 dependent AP-1 activation negatively regulates it