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NR4A1 — RELA
Text-mined interactions from Literome
Hong et al., Mol Cell Biol 2004
:
In addition, overexpression of the p65 ( RelA ) subunit of NF-kappaB showed the same effect as TNF-alpha and
inhibited Nur77 transactivation, suggesting the involvement of
NF-kappaB activation in the observed gene repression ... The
NF-kappaB inhibition of
Nur77 transactivation was likely due to the competition of p65 for Nur77 binding with coactivators ... Finally, chromatin immunoprecipitation assays revealed that TNF-alpha treatment caused the recruitment of NF-kappaB to the promoter of the steroidogenic-enzyme p450c17 gene, supporting the hypothesis that the TNF-alpha mediated gene repression involves
NF-kappaB inhibition of the transcriptional activity of
Nur77 and other orphan nuclear receptors
de Léséleuc et al., Cell Death Differ 2006
:
Nur77 overexpression
led to enhanced
NF-kappaB activity, and DNA binding inhibitors confirmed the contribution of NF-kappaB to Nur77 antiapoptotic activity