Gene interactions and pathways from curated databases and text-mining

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NR4A1 — RELA

Text-mined interactions from Literome

Hong et al., Mol Cell Biol 2004 : In addition, overexpression of the p65 ( RelA ) subunit of NF-kappaB showed the same effect as TNF-alpha and inhibited Nur77 transactivation, suggesting the involvement of NF-kappaB activation in the observed gene repression ... The NF-kappaB inhibition of Nur77 transactivation was likely due to the competition of p65 for Nur77 binding with coactivators ... Finally, chromatin immunoprecipitation assays revealed that TNF-alpha treatment caused the recruitment of NF-kappaB to the promoter of the steroidogenic-enzyme p450c17 gene, supporting the hypothesis that the TNF-alpha mediated gene repression involves NF-kappaB inhibition of the transcriptional activity of Nur77 and other orphan nuclear receptors
de Léséleuc et al., Cell Death Differ 2006 : Nur77 overexpression led to enhanced NF-kappaB activity, and DNA binding inhibitors confirmed the contribution of NF-kappaB to Nur77 antiapoptotic activity