Gene interactions and pathways from curated databases and text-mining

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MAPK6 — PAK1

Text-mined interactions from Literome

Dechert et al., Am J Physiol Cell Physiol 2001 (MAP Kinase Signaling System) : Phosphorylation of p38 mitogen activated protein kinase ( MAPK ) in cells overexpressing wild-type PAK1 was similar to vector controls ; however, p38 MAPK phosphorylation was severely reduced by overexpression of the PAK1 mutant
Zang et al., J Biol Chem 2002 : The extent of binding to Raf-1 is correlated with the ability of Pak to phosphorylate Raf and induce mitogen activated protein kinase activation
Zhong et al., Blood 2003 (MAP Kinase Signaling System) : PAK1 ( p21 activated kinase 1 ) activation is induced by C albicans, suggesting that PAK1 may also be involved in the Rac1 activation of MAPK/ERK
Huang et al., Biochem J 2006 : The results demonstrate reciprocal inhibition between two pathways downstream of PI3K, with ILK inhibiting PAK1 , and p38 MAPK inhibiting ILK
Rousseau et al., Cell Signal 2006 (MAP Kinase Signaling System) : We also show that the activation of p38alpha MAPK in response to CXCL12 requires the p21 activated protein kinases (PAK)-1 and PAK-2
De la Mota-Peynado et al., J Biol Chem 2011 (MAP Kinase Signaling System) : Collectively, our results identify the Erk3 protein as a novel class I Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK signaling
Shrestha et al., Oncogene 2012 (Breast Neoplasms...) : Moreover, we show that PAK1 simultaneously activates MAPK and MET signaling ; the latter via inhibition of merlin
Qing et al., Tumour Biol 2012 (Colorectal Neoplasms...) : PAK1 dependent MAPK pathway activation is required for colorectal cancer cell proliferation
Huang et al., Mol Cell Biol 1998 : These data indicate that separate signals are required for activation and inactivation of Paks and that, in contrast to other cell types, activated Pak does not trigger activation of JNK or p38-MAPK in neutrophils