We have a suspicion that you are an automated web bot software, not a real user.
To keep our site fast for other users, we have slowed down this page.
The slowdown will gradually disappear.
If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu.
Also note that all data for hgGeneGraph can be obtained through our public MySQL server and
all our software source code is available and can be installed locally onto your own computer.
If you are unsure how to use these resources, do not hesitate to contact us.
Walker et al., Biochem Biophys Res Commun 2006
:
The aim of this study was to examine the role of AMPK in modulating poly ( ADP-ribose ) polymerase ( PARP ), a nuclear enzyme involved in maintaining chromatin structure and DNA repair ... These data suggest a novel role for AMPK in regulating PARP activity through a direct interaction involving phosphorylation
Li et al., Neurosci Lett 2010
(Stroke) :
PolyADP ribose polymerase ( PARP ) , a key mediator of ischemic cell death, stimulates AMPK activation, yet activation of PARP appears to be selectively detrimental in male brain
Son et al., Toxicol Appl Pharmacol 2011
:
Consequently, these results suggest that cadmium mediated ROS generation causes PARP activation and energy depletion, and eventually induces autophagy through the activation of LKB1-AMPK signaling and the down-regulation of mTOR in skin epidermal cells