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JUN — PLAU
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
JUN
→
Complex of PLAU-PLAUR
(increases, PLAU/PLAUR Activity)
Evidence: In addition to the influence on the protein kinase system, uPA can regulate gene expression. The binding of uPA to uPAR has been shown to stimulate downstream up-regulation of various transcription factors: AP1 in the HT-1080 cell line [54] and c-Jun, c-Myc, and c-fos factors in SaOS2 cells [55]. Recently, the possibility of signal transduction into the cell by the receptor systems associated with urokinase endocytosis was shown [56].
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NCI Pathway Database Osteopontin-mediated events:
AP1 complex (FOS-JUN)
→
uPA (PLAU)
(transcription, activates)
Mi et al., Carcinogenesis 2006
Evidence: mutant phenotype, assay, other species
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NCI Pathway Database AP-1 transcription factor network:
JUN/JUN-FOS/RACO-1 complex (JUN-FOS_JUN)
→
uPA (PLAU)
(transcription, activates)
Davies et al., Nat Cell Biol 2010
Evidence: mutant phenotype, reporter gene, physical interaction
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NCI Pathway Database AP-1 transcription factor network:
JUN/FOS complex (FOS-JUN)
→
uPA (PLAU)
(transcription, activates)
D'Orazio et al., Gene 1997*
Evidence: reporter gene
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NCI Pathway Database AP-1 transcription factor network:
JUN/FOS/GR/TRIP6/cortisol/GR alpha (dimer) complex (FOS-JUN-TRIP6-NR3C1)
→
uPA (PLAU)
(transcription, inhibits)
Diefenbacher et al., Mol Endocrinol 2008, Miralles et al., Mol Cell Biol 1998
Evidence: reporter gene, physical interaction
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NCI Pathway Database AP-1 transcription factor network:
JUN/FOS/TRIP6 complex (FOS-JUN-TRIP6)
→
uPA (PLAU)
(transcription, activates)
Diefenbacher et al., Mol Endocrinol 2008, Miralles et al., Mol Cell Biol 1998
Evidence: reporter gene, physical interaction
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NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
uPA (PLAU)
(transcription, activates)
Cirillo et al., Mol Cell Biol 1999*, De Cesare et al., Oncogene 1995*, D'Orazio et al., Gene 1997*
Evidence: reporter gene, physical interaction
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NCI Pathway Database ATF-2 transcription factor network:
JUN/FOS complex (FOS-JUN)
→
uPA (PLAU)
(transcription, inhibits)
Cirillo et al., Mol Cell Biol 1999*, De Cesare et al., Oncogene 1995*, D'Orazio et al., Gene 1997*
Evidence: reporter gene, physical interaction
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WikiPathways Wnt Signaling Pathway and Pluripotency:
EP300
→
Complex of 11 proteins
(activation)
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WikiPathways Wnt Signaling Pathway and Pluripotency:
ZBTB33
→
Complex of 11 proteins
(mim-inhibition)
Text-mined interactions from Literome
Kobayashi et al., J Biol Chem 2001
(MAP Kinase Signaling System...) :
PMA could also activate a signaling pathway involving
MEK1/ERK2/c-Jun dependent
uPA expression
Okan et al., Oncogene 2001
:
The small-GTPase RalA activates transcription of the
urokinase plasminogen activator receptor ( uPAR ) gene via an
AP1 dependent mechanism
Kobayashi et al., Hum Cell 2001
(MAP Kinase Signaling System...) :
We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase, since PMA could also activate a signaling pathway involving
MEK/ERK/c-Jun dependent
uPA expression
Das et al., J Biol Chem 2004
(Breast Neoplasms...) :
However, the role ( s ) of OPN on
AP-1 mediated
uPA secretion and cell motility and the involvement of c-Src/epidermal growth factor receptor (EGFR) in these processes in breast cancer cells are not well defined ... To our knowledge, this is the first report that OPN induces alpha(v)beta(3) integrin mediated AP-1 activity and uPA secretion by activating c-Src/EGFR/ERK signaling pathways and further demonstrates a functional molecular link between OPN induced integrin/c-Src dependent EGFR phosphorylation and
ERK/AP-1 mediated
uPA secretion, and all of these ultimately control the motility of breast cancer cells
Amos et al., J Neuropathol Exp Neurol 2010
(Glioblastoma...) :
In summary, these results suggest that c-Src, mitogen activated protein kinase, and a composite
activator protein 1 on the uPA promoter are
responsible for EGF induced
uPA expression and GBM invasion
Huang et al., J Cell Physiol 2012
(Colorectal Neoplasms...) :
Inhibition of Sp1 and
AP-1 activation
blocked the SDF-1 induced expression and activity of the
uPA promoter
Lee et al., J Biol Chem 1994
:
DNA-protein interaction studies, together with mRNA and protein analyses, indicate that
c-Jun , but not c-Fos, is
involved in OA-dependent
uPA gene induction
Lee et al., Nucleic Acids Res 1993
:
Here we show that the induction of the
uPA gene by CSR is
mediated by the activation of
c-Jun which interacts with an AP-1-like site located 2 kb upstream of the uPA gene
Dear et al., FEBS Lett 1997
(Fibrosarcoma...) :
Since transcription factors bound to AP-1 recognition sequences within the PAI-2 gene promoter play a role in basal and phorbol ester mediated induction of PAI-2 gene expression, we hypothesised that
u-PA/u-PAR mediated modulation of
AP-1 activity would in turn influence constitutive and inducible PAI-2 gene expression
Miralles et al., Mol Cell Biol 1998
:
This activation links external UV stimulation and
AP1 dependent
uPA transcription, providing a transcription coupled signal transduction pathway for the induction of the murine uPA gene by UV