Gene interactions and pathways from curated databases and text-mining

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CASP14 — PLCG1

Text-mined interactions from Literome

Woo et al., Biochem Biophys Res Commun 2004 : Overexpression of a constitutively active Akt ( myr-Akt ) in U937 cells inhibited the induction of apoptosis, activation of caspase 3, and PLC-gamma1 cleavage by chrysin
Hachimura et al., Ann N Y Acad Sci 2004 : Thus, as a consequence of caspase activation, orally tolerant CD4 T cells could not form normal TCR signaling complexes associated with GADS and showed downregulated PLC-gamma1 activation, which resulted in impairment of TCR induced calcium signaling
Park et al., Biol Pharm Bull 2007 : The increase in apoptosis induced by beta-sitosterol was associated with down-regulation of Bcl-2, degradation of poly- ( ADP-ribose ) polymerase ( PARP ) and phospholipase C (PLC)-gamma1 protein, and activation of caspase-3
Park et al., Biochem Biophys Res Commun 2008 : The caspase-8 inhibitor ( z-IETD-fmk ), which failed to influence pFPhe induced caspase-9 activation, completely blocked caspase-8 activation and PLCgamma-1 degradation with a marked reduction in caspase-3 activation and PARP degradation, indicating pFPhe induced caspase-8 activation as a downstream event of mitochondria dependent activation of caspase-9
Oh et al., Apoptosis 2008 (Leukemia) : Furthermore, we have shown that overexpression of Bcl-2 and active Akt ( myr-Akt ) in U937 cells inhibited the induction of apoptosis, activation of caspase-3 , and PLC-gamma1 cleavage by withaferin A. Taken together, our results indicated that the JNK and Akt pathways and inhibition of NF-kappaB activity were key regulators of apoptosis in response to withaferin A in human leukemia U937 cells