UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to PXN

PRKAR1A — PXN

Pathways - manually collected, often from reviews:

BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → PKA complex (PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B) (modification, collaborate)
NCI Pathway Database Alpha4 beta1 integrin signaling events: Type I PKA complex (PRKACA-PRKAR1A-PRKAR1B-PRKACB) → Paxillin (PXN) (modification, activates) Liu et al., Nature 1999, Han et al., J Biol Chem 2001, Han et al., J Biol Chem 2003, Nishiya et al., Nat Cell Biol 2005
Evidence: assay, physical interaction
NCI Pathway Database Alpha4 beta1 integrin signaling events: Type I PKA complex (PRKACA-PRKAR1A-PRKAR1B-PRKACB) → alpha4/beta1 Integrin/Fibronectin/Paxillin complex (PXN-ITGA4-ITGB1-FN1) (modification, activates)
Liu et al., Nature 1999, Han et al., J Biol Chem 2001, Han et al., J Biol Chem 2003, Nishiya et al., Nat Cell Biol 2005
Evidence: assay, physical interaction