◀ Back to CTNNB1

CTNNB1 — PRKCA

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PRKCA — CTNNB1 (physical association, affinity chromatography technology) Mertz et al., Proc Natl Acad Sci U S A 2011*
• IRef Innatedb Interaction: PRKCA — CTNNB1 (unknown, -) Zhu et al., EMBO J 2011*
• IRef Intact Interaction: PRKCA — CTNNB1 (physical association, anti bait coimmunoprecipitation) Zhu et al., EMBO J 2011*

Text-mined interactions from Literome

Wang et al., J Cell Physiol 2001 (Colonic Neoplasms) : We found that the induction of E-cadherin and alpha- and beta-catenin by TGFbeta was also dependent on protein kinase Calpha , whereas the induction of gamma-catenin was independent of protein kinase Calpha but dependent on other protein kinase C isoforms
Gwak et al., J Cell Sci 2006 : Moreover, the depletion of PKCalpha inhibited the phosphorylation and degradation of beta-catenin
Gwak et al., J Cell Mol Med 2009 (Colonic Neoplasms) : Activation of PKC-alpha inhibited beta-catenin response transcription by down-regulation of intracellular beta-catenin and induced phosphorylation of the N-terminal serine and threonine residues ( Ser33/Ser37/Thr41 ) of beta-catenin, marking it for proteasomal degradation, in colon cancer cells ... Notably, the Ser45 residue of beta-catenin was essential for PKC-alpha induced beta-catenin down-regulation in colon cancer cells