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IFNG — PSME2

Pathways - manually collected, often from reviews:

• KEGG Antigen processing and presentation: IFNG → PSME1/PSME2/PSME3 (protein-protein, activation)
• WikiPathways Proteasome Degradation: IFNG → PSME1/PSME2/PSME3 (activation)

Text-mined interactions from Literome

Früh et al., Curr Opin Immunol 1999 : IFN-gamma upregulates gene expression of several proteasomal subunits as well as the proteasome regulator PA28 ; this implicated their role in antigen degradation
van Hall T et al., J Exp Med 2000 : Interferon (IFN)-gamma induces expression of three catalytically active proteasome subunits ( LMP2, LMP7, and MECL-1 ) and the proteasome associated activator PA28
Fabunmi et al., J Cell Sci 2001 : Interferon gamma regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies
Krüger et al., Rev Physiol Biochem Pharmacol 2003 : In addition, interferon-gamma also induces the synthesis of the proteasome activator PA28 which, as part of the so-called hybrid proteasome, exerts a more selective function in antigen presentation
Kloetzel et al., Nat Immunol 2004 : Proteasome dependent epitope processing is greatly improved through the interferon-gamma induced formation of immunoproteasomes and the activator complex PA28
Kloetzel et al., Biochim Biophys Acta 2004 : Interferon-gamma induces the formation of immunoproteasomes and the synthesis of the proteasome activator PA28
Piccinini et al., Anticancer Res 2005 (Central Nervous System Neoplasms...) : By IFN-gamma and TNFalpha stimulus, these subunits are replaced by their counterparts LMP2, MECL-1 and LMP7, defined inducible subunits, thus originating the immunoproteasome, and expression of the proteasome activator PA28 is enhanced
Stratford et al., FEBS Lett 2006 : In contrast, levels of the 11S proteasome regulator, PA28, were increased by IFN-gamma even in senescent cells, and both immunosubunits and PA28 increased with the reversible growth arrest in confluent cell cultures