Koutsioumpa et al., Eur J Pharmacol 2009
:
Aprotinin inhibits pleiotrophin proteolysis and induces expression and secretion of pleiotrophin through an AP-1 dependent transcriptional activation of the pleiotrophin gene, and pleiotrophin seems to mediate the stimulatory effects of aprotinin on cell migration through its receptor protein tyrosine phosphatase beta/zeta
Poimenidi et al., Anticancer Res 2009
(Glioblastoma) :
Serum stimulates Pleiotrophin gene expression in an AP-1 dependent manner in human endothelial and glioblastoma cells