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GRB2 — PTPN11

Pathways - manually collected, often from reviews:

• BioCarta insulin signaling pathway: None → SHP-2/GRB2/SOS-1 complex (SOS1-PTPN11-GRB2) (modification, collaborate)
  
• BioCarta insulin signaling pathway: SHP-2/GRB2/SOS-1 complex (SOS1-PTPN11-GRB2) → SOS-1 (SOS1) (modification, collaborate)
• BioCarta insulin signaling pathway: SHP-2/GRB2/SOS-1 complex (SOS1-PTPN11-GRB2) → SHP-2 (PTPN11) (modification, collaborate)
• BioCarta insulin signaling pathway: SHP-2/GRB2/SOS-1 complex (SOS1-PTPN11-GRB2) → GRB2 (modification, collaborate)
• BioCarta insulin signaling pathway: SHP-2 (PTPN11) → GRB2 (modification, collaborate)
• KEGG Jak-STAT signaling pathway: GRB2 → PTPN11 (protein-protein, binding/association)
• KEGG Neurotrophin signaling pathway: GRB2 → PTPN11 (protein-protein, binding/association)
• NCI Pathway Database PDGFR-beta signaling pathway: None → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
  Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
  Evidence: mutant phenotype
• NCI Pathway Database PDGFR-beta signaling pathway: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
  Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
  Evidence: mutant phenotype
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) → None (modification, activates) Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
  Evidence: mutant phenotype
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: None → FRS2 family/SHP2/GRB2/SOS1 complex (FRS3_FRS2-PTPN11-GRB2-SOS1) (modification, collaborate)
  Wright et al., Mol Biol Cell 1997
  Evidence: other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → FRS2 family/SHP2/GRB2/SOS1 complex (FRS3_FRS2-PTPN11-GRB2-SOS1) (modification, collaborate)
  Wright et al., Mol Biol Cell 1997
  Evidence: other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/GRB2/SOS1 complex (FRS3_FRS2-PTPN11-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Wright et al., Mol Biol Cell 1997
  Evidence: other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/GRB2/SOS1 complex (FRS3_FRS2-PTPN11-GRB2-SOS1) → None (modification, activates) Wright et al., Mol Biol Cell 1997
  Evidence: other species
• NCI Pathway Database IL2 signaling events mediated by PI3K: None → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, collaborate)
  Augustine et al., Mol Cell Biol 1991, Gómez et al., J Immunol 1997
  Evidence: assay, other species
• NCI Pathway Database IL2 signaling events mediated by PI3K: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → PKC zeta (PRKCZ) (modification, activates) Gómez et al., Exp Cell Res 1995, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GRB2/GAB1 complex (MET-GRB2-GAB1-HGF) → SHP2 (PTPN11) (modification, collaborate) Schaeper et al., J Cell Biol 2000, Maroun et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GRB2/GAB1 complex (MET-GRB2-GAB1-HGF) → HGF(dimer)/MET(dimer)/GRB2/GAB1/SHP2 complex (MET-GRB2-GAB1-PTPN11-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Maroun et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): SHP2 (PTPN11) → HGF(dimer)/MET(dimer)/GRB2/GAB1/SHP2 complex (MET-GRB2-GAB1-PTPN11-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Maroun et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database FGF signaling pathway: GRB2 (GRB2) → SHP2 (PTPN11) (modification, collaborate) Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database FGF signaling pathway: GRB2 (GRB2) → SHP2/GAB1/GRB2/FRS2/FGFR/FGF/Syndecan-2 complex (PTPN11-GAB1-GRB2-FRS2-SDC2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database FGF signaling pathway: Gab1 (GAB1) → SHP2/GAB1/GRB2/FRS2/FGFR/FGF/Syndecan-2 complex (PTPN11-GAB1-GRB2-FRS2-SDC2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database FGF signaling pathway: SHP2 (PTPN11) → SHP2/GAB1/GRB2/FRS2/FGFR/FGF/Syndecan-2 complex (PTPN11-GAB1-GRB2-FRS2-SDC2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database FGF signaling pathway: FGFR/FGF/Syndecan-2/FRS2 complex (SDC2-FRS2) → SHP2/GAB1/GRB2/FRS2/FGFR/FGF/Syndecan-2 complex (PTPN11-GAB1-GRB2-FRS2-SDC2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Li et al., Mol Cell Biol 1994
  Evidence: physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
  Li et al., Mol Cell Biol 1994
  Evidence: physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: GRB2/SOS1 complex (GRB2-SOS1) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
  Li et al., Mol Cell Biol 1994
  Evidence: physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA) → GRB2/GAB2 complex (GRB2-GAB2) (modification, collaborate)
  Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2/GRB2/GAB2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA-GRB2-GAB2) (modification, collaborate)
  Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: GRB2/GAB2 complex (GRB2-GAB2) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2/GRB2/GAB2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA-GRB2-GAB2) (modification, collaborate)
  Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database SHP2 signaling: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database SHP2 signaling: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database SHP2 signaling: PI3K complex (PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database SHP2 signaling: RHOA/GTP complex (RHOA) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, activates)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL6-mediated signaling events: GRB2/SOS1/GAB family/SHP2/PI3K complex (GRB2-SOS1-GAB1_GAB2-PTPN11-PIK3CA-PIK3R1) → AKT1 (AKT1) (modification, activates) Jee et al., J Invest Dermatol 2002
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): Erk1-2 (MAPK3/MAPK1) → HGF(dimer)/MET(dimer)/GRB2/GAB1/SHP2 complex (MET-GRB2-GAB1-PTPN11-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Maroun et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database SHP2 signaling: None → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
  Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
  Evidence: mutant phenotype
• NCI Pathway Database SHP2 signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
  Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
  Evidence: mutant phenotype
• NCI Pathway Database SHP2 signaling: PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) → None (modification, activates) Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → SHP2 (PTPN11) (modification, collaborate) Kurokawa et al., Oncogene 2001
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: SHP2 (PTPN11) → RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF) → RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001
  Evidence: assay, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: GRB2/SOS1/GAB family/SHP2 complex (GRB2-SOS1-GAB1_GAB2-PTPN11) → GRB2/SOS1/GAB family complex (GRB2-SOS1-GAB1_GAB2) (modification, collaborate)
  Kim et al., Mol Cell Biol 1999, Podar et al., J Biol Chem 2004
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL6-mediated signaling events: GRB2/SOS1/GAB family/SHP2 complex (GRB2-SOS1-GAB1_GAB2-PTPN11) → SHP2 (PTPN11) (modification, collaborate) Kim et al., Mol Cell Biol 1999, Podar et al., J Biol Chem 2004
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL6-mediated signaling events: GRB2/SOS1/GAB family complex (GRB2-SOS1-GAB1_GAB2) → SHP2 (PTPN11) (modification, collaborate) Kim et al., Mol Cell Biol 1999, Podar et al., J Biol Chem 2004
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL2-mediated signaling events: Erk1-2-active (MAPK3/MAPK1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → SHP2 (PTPN11) (modification, collaborate) Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: SHP2 (PTPN11) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: SHP2 (PTPN11) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL5-mediated signaling events: GRB2 (GRB2) → IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2/SHP2 complex (CSF2RB-IL5-IL5RA-JAK2-PTPN11) (modification, collaborate)
  Pazdrak et al., J Exp Med 1997
  Evidence: physical interaction
• NCI Pathway Database IL5-mediated signaling events: GRB2 (GRB2) → IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2/SHP2/GRB2 complex (CSF2RB-IL5-IL5RA-JAK2-PTPN11-GRB2) (modification, collaborate)
  Pazdrak et al., J Exp Med 1997
  Evidence: physical interaction
• NCI Pathway Database IL5-mediated signaling events: IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2/SHP2 complex (CSF2RB-IL5-IL5RA-JAK2-PTPN11) → IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2/SHP2/GRB2 complex (CSF2RB-IL5-IL5RA-JAK2-PTPN11-GRB2) (modification, collaborate)
  Pazdrak et al., J Exp Med 1997
  Evidence: physical interaction
• NCI Pathway Database IL2 signaling events mediated by PI3K: None → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
  Gu et al., Mol Cell Biol 2000, Lindemann et al., J Biol Chem 2003, Akbar et al., Eur J Immunol 1996, Ahmed et al., Proc Natl Acad Sci U S A 1997, Reif et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database SHP2 signaling: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → SHP2 (PTPN11) (modification, collaborate) Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database SHP2 signaling: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: RHOA/GTP complex (RHOA) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, activates)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/GRB2/SOS1 complex (FRS3_FRS2-PTPN11-GRB2-SOS1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Hadari et al., Mol Cell Biol 1998
  Evidence: physical interaction
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/GRB2/SOS1 complex (FRS3_FRS2-PTPN11-GRB2-SOS1) → FRS2 family/SHP2 complex (FRS3_FRS2-PTPN11) (modification, collaborate)
  Hadari et al., Mol Cell Biol 1998
  Evidence: physical interaction
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: GRB2/SOS1 complex (GRB2-SOS1) → FRS2 family/SHP2 complex (FRS3_FRS2-PTPN11) (modification, collaborate)
  Hadari et al., Mol Cell Biol 1998
  Evidence: physical interaction
• NCI Pathway Database SHP2 signaling: SHP2 (PTPN11) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2 signaling events mediated by STAT5: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → STAT5 (dimer)-active (STAT5B/STAT5A) (transcription, activates)
  Moriggl et al., Immunity 1999, Brennan et al., Immunity 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database SHP2 signaling: GRB2 (GRB2) → SHP2 (PTPN11) (modification, collaborate) Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database SHP2 signaling: GRB2 (GRB2) → SHP2/GAB/GRB2/FRS2/FGFR/FGF/Syndecan-2 complex (PTPN11-GAB1-GRB2-FRS2-SDC2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database SHP2 signaling: Gab1 (GAB1) → SHP2/GAB/GRB2/FRS2/FGFR/FGF/Syndecan-2 complex (PTPN11-GAB1-GRB2-FRS2-SDC2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database SHP2 signaling: SHP2 (PTPN11) → SHP2/GAB/GRB2/FRS2/FGFR/FGF/Syndecan-2 complex (PTPN11-GAB1-GRB2-FRS2-SDC2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database SHP2 signaling: FGFR/FGF/Syndecan-2/FRS2 complex (SDC2-FRS2) → SHP2/GAB/GRB2/FRS2/FGFR/FGF/Syndecan-2 complex (PTPN11-GAB1-GRB2-FRS2-SDC2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database SHP2 signaling: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Li et al., Mol Cell Biol 1994
  Evidence: physical interaction
• NCI Pathway Database SHP2 signaling: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
  Li et al., Mol Cell Biol 1994
  Evidence: physical interaction
• NCI Pathway Database SHP2 signaling: GRB2/SOS1 complex (GRB2-SOS1) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
  Li et al., Mol Cell Biol 1994
  Evidence: physical interaction
• NCI Pathway Database IL2-mediated signaling events: RAF1 (RAF1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
  Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → SHP2 (PTPN11) (modification, collaborate) Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: SHP2 (PTPN11) → RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction, other species
• NCI Pathway Database ErbB2/ErbB3 signaling events: SHP2 (PTPN11) → ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 complex (ERBB2-ERBB3-NRG1-SHC1-GRB2-SOS1) (modification, inhibits)
  Tanowitz et al., J Neurosci 1999, Goodearl et al., Dev Neurosci 2001, Vijapurkar et al., J Biol Chem 1998, Olayioye et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB2/ErbB3 signaling events: SHP2 (PTPN11) → GRB2/SOS1 complex (GRB2-SOS1) (modification, inhibits)
  Tanowitz et al., J Neurosci 1999, Goodearl et al., Dev Neurosci 2001, Vijapurkar et al., J Biol Chem 1998, Olayioye et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction
• NCI Pathway Database IL6-mediated signaling events: STAT3 (dimer)/FOXO1 complex (STAT3-FOXO1) → GRB2/SOS1/GAB family/SHP2 complex (GRB2-SOS1-GAB1_GAB2-PTPN11) (transcription, activates)
  Kortylewski et al., J Biol Chem 2003, Wegenka et al., Mol Cell Biol 1993, Schaper et al., Biochem J 1998
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: GRB2/SOS1/GAB family/SHP2 complex (GRB2-SOS1-GAB1_GAB2-PTPN11) → A2M (A2M) (transcription, inhibits) Kortylewski et al., J Biol Chem 2003, Wegenka et al., Mol Cell Biol 1993, Schaper et al., Biochem J 1998
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database SHP2 signaling: RAF1 (RAF1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
  Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
  Evidence: mutant phenotype
• NCI Pathway Database SHP2 signaling: SHP2 (PTPN11) → EGFR/EGFR/EGF/EGF/GRB2/GAB1 complex (EGFR-EGF-GRB2-GAB1) (modification, activates)
  Zhang et al., Mol Cell Biol 2002*, Montagner et al., J Biol Chem 2005
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: GRB2/SOS1/GAB family/SHP2 complex (GRB2-SOS1-GAB1_GAB2-PTPN11) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Takahashi-Tezuka et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL6-mediated signaling events: GRB2/SOS1/GAB family/SHP2 complex (GRB2-SOS1-GAB1_GAB2-PTPN11) → GRB2/SOS1/GAB family/SHP2/PI3K complex (GRB2-SOS1-GAB1_GAB2-PTPN11-PIK3CA-PIK3R1) (modification, collaborate)
  Takahashi-Tezuka et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL6-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → GRB2/SOS1/GAB family/SHP2/PI3K complex (GRB2-SOS1-GAB1_GAB2-PTPN11-PIK3CA-PIK3R1) (modification, collaborate)
  Takahashi-Tezuka et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: GRB2 → PTPN11 (reaction) Lennartsson et al., Oncogene 1999, Gual et al., Oncogene 2000, Cunnick et al., J Biol Chem 2001*, Ong et al., Proc Natl Acad Sci U S A 2001, Nicholson et al., EMBO J 2001*, Wong et al., Proc Natl Acad Sci U S A 2002, Fong et al., J Biol Chem 2003, Agazie et al., Mol Cell Biol 2003, Kapoor et al., Mol Cell Biol 2004*, Hanafusa et al., J Biol Chem 2004*, Dance et al., Cell Signal 2008*, Tauchi et al., J Biol Chem 1994, Kanai et al., J Biol Chem 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998
• Reactome Reaction: GRB2 → PTPN11 (direct_complex)
• Reactome Reaction: GRB2 → PTPN11 (indirect_complex) Lennartsson et al., Oncogene 1999, Gual et al., Oncogene 2000, Cunnick et al., J Biol Chem 2001*, Ong et al., Proc Natl Acad Sci U S A 2001, Nicholson et al., EMBO J 2001*, Wong et al., Proc Natl Acad Sci U S A 2002, Agazie et al., Mol Cell Biol 2003, Kapoor et al., Mol Cell Biol 2004*, Tauchi et al., J Biol Chem 1994, Kanai et al., J Biol Chem 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998
• WikiPathways ESC Pluripotency Pathways: PTPN11 → GRB2 (mim-binding)
• WikiPathways Hepatitis C and Hepatocellular Carcinoma: PTPN11 → GRB2 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of 168 proteins Blagoev et al., Nat Biotechnol 2003
• IRef Bind Interaction: PTPN11 — GRB2 Tauchi et al., J Biol Chem 1994, Tauchi et al., J Biol Chem 1994*
• IRef Bind_translation Interaction: PTPN11 — GRB2 (coimmunoprecipitation) Tauchi et al., J Biol Chem 1994, Tauchi et al., J Biol Chem 1994*
• IRef Bind_translation Interaction: PTPN11 — GRB2 (affinity chromatography technology) Tauchi et al., J Biol Chem 1994
• IRef Bind_translation Interaction: PTPN11 — GRB2 (coimmunoprecipitation) Tauchi et al., J Biol Chem 1994
• IRef Biogrid Interaction: PTPN11 — GRB2 (physical association, affinity chromatography technology) Craddock et al., J Biol Chem 1997
• IRef Biogrid Interaction: PTPN11 — GRB2 (physical association, affinity chromatography technology) Bisson et al., Nat Biotechnol 2011
• IRef Biogrid Interaction: PTPN11 — GRB2 (physical association, affinity chromatography technology) Ganju et al., J Biol Chem 2000*
• IRef Biogrid Interaction: PTPN11 — GRB2 (physical association, affinity chromatography technology) Bennett et al., Proc Natl Acad Sci U S A 1994*
• IRef Biogrid Interaction: PTPN11 — GRB2 (direct interaction, far western blotting) Ward et al., Biochim Biophys Acta 1998*
• IRef Biogrid Interaction: PTPN11 — GRB2 (direct interaction, pull down) Yin et al., J Biol Chem 1997*
• IRef Biogrid Interaction: PTPN11 — GRB2 (direct interaction, pull down) Tang et al., Oncogene 1997*
• IRef Biogrid Interaction: PTPN11 — GRB2 (physical association, affinity chromatography technology) Tang et al., J Biol Chem 1999*
• IRef Biogrid Interaction: PTPN11 — GRB2 (physical association, affinity chromatography technology) Hadari et al., Mol Cell Biol 1998
• IRef Biogrid Interaction: PTPN11 — GRB2 (physical association, affinity chromatography technology) Zhang et al., J Leukoc Biol 1999*
• IRef Biogrid Interaction: PTPN11 — GRB2 (physical association, affinity chromatography technology) Wong et al., J Biol Chem 1996*
• IRef Biogrid Interaction: PTPN11 — GRB2 (physical association, affinity chromatography technology) Brehme et al., Proc Natl Acad Sci U S A 2009
• MIPS CORUM GRB2-SHP-2 complex, PDGF stimulated: GRB2-SHP-2 complex, PDGF stimulated complex (GRB2-PTPN11) Bazenet et al., Mol Cell Biol 1996*
• IRef Corum Interaction: GRB2 — PTPN11 (association, coimmunoprecipitation) Bazenet et al., Mol Cell Biol 1996*
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Bazenet et al., Mol Cell Biol 1996*
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Hadari et al., Mol Cell Biol 1998
• IRef Hprd Interaction: PTPN11 — GRB2 (in vivo) Minoo et al., Cell Signal 2003*, Bennett et al., Proc Natl Acad Sci U S A 1994*, Wong et al., J Biol Chem 1996*
• IRef Intact Interaction: Complex of 228 proteins (association, pull down) Blagoev et al., Nat Biotechnol 2003
• IRef Intact Interaction: Complex of PIK3R1-EGFR-PTPN11-GAB2-GRB2 (association, anti tag coimmunoprecipitation) Brummer et al., J Biol Chem 2006*
• IRef Intact Interaction: Complex of 13 proteins (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Intact Interaction: Complex of 37 proteins (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Intact Interaction: Complex of PTPN11-GAB2-GRB2 (association, anti bait coimmunoprecipitation) Brummer et al., EMBO J 2008
• IRef Intact Interaction: GRB2 — PTPN11 (physical association, anti bait coimmunoprecipitation) Tauchi et al., J Biol Chem 1994
• IRef Intact Interaction: Complex of 38 proteins (association, pull down) Blagoev et al., Nat Biotechnol 2003
• IRef Ophid Interaction: GRB2 — PTPN11 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: GRB2 — PTPN11 (aggregation, confirmational text mining) Wong et al., J Biol Chem 1996*

Text-mined interactions from Literome

Tang et al., J Biol Chem 1999 : The agonist induced direct interaction of Grb2 with SHP-2 is mediated by the SH2 domain of Grb2 and the tyrosine phosphorylation of SHP-2
Yu et al., J Biol Chem 2006 (Leukemia) : The E76K mutation in the N-terminal Src homology 2 domain increased interactions of mutant SHP-2 with Grb2 , Gab2, and p85, leading to hyperactivation of IL-3 induced Erk and phosphatidylinositol 3-kinase (PI3K) pathways
Ahmed et al., J Cell Biol 2013 (MAP Kinase Signaling System) : Both reciprocal activities of FGFR2 and Shp2 were inhibited by binding of Grb2 to the receptor
Wong et al., J Biol Chem 1996 : Additional experiments indicated that neither the binding of the nucleotide exchange factor Sos to GRB2 nor tyrosine phosphorylation of PTP1D was required for EGF stimulated coupling of PTP1D to GRB2
Deb et al., J Biol Chem 1998 : Dominant negative forms of SHP-2 had no effect on EGF stimulated interaction of GRB2 with EGFR or SHC, nor did they influence phosphorylation of SHC and SHC/EGFR association