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AKT3 — RAD51
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Albert et al., Mol Cancer Ther 2006
(Breast Neoplasms) :
Irradiation induced
Akt and mTOR signaling, and this signaling is
attenuated by
RAD001
Mabuchi et al., Cancer Res 2007
(Disease Models, Animal...) :
In vivo
effects of
RAD001 on
Akt-mTOR signaling, tumor cell proliferation, and blood vessel area were analyzed by immunohistochemistry and Western blot analysis
Tamburini et al., Blood 2008
(Leukemia, Myeloid, Acute) :
In 19 AML samples with constitutive PI3K/Akt activation, the rapamycin derivative inhibitor everolimus (
RAD001 )
increased Akt phosphorylation ... This mTOR C1-mediated Akt up-regulation was explained by an insulin-like growth factor-1 (IGF-1)/IGF-1 receptor autocrine loop : ( 1 ) blast cells expressed functional IGF-1 receptors, and IGF-1 induced
Akt activation was
increased by
RAD001 , ( 2 ) a neutralizing anti-IGF-1R alpha-IR3 monoclonal antibody reversed the RAD001 induced Akt phosphorylation, and ( 3 ) autocrine production of IGF-1 was detected in purified blast cells by quantitative reverse transcription-polymerase chain reaction and immunofluorescence ... This
RAD001 induced
PI3K/Akt up-regulation was due to an up-regulated expression of the IRS2 adaptor
Breuleux et al., Mol Cancer Ther 2009
(Neoplasms) :
In contrast, increased
AKT S473 phosphorylation
induced by
RAD001 did not correlate
Ko et al., Mol Cancer Res 2009
(Carcinoma, Non-Small-Cell Lung...) :
Roles of MKK1/2-ERK1/2 and phosphoinositide
3-kinase-AKT signaling pathways in erlotinib induced
Rad51 suppression and cytotoxicity in human non-small cell lung cancer cells ... In this study, we investigated the
roles of ERK1/2 and
AKT signaling pathways in regulating
Rad51 expression and cytotoxic effects in different NSCLC cell lines treated with erlotinib ... Blocking the activations of ERK1/2 and
AKT by MKK1/2 inhibitor ( U0126 ) and phosphoinositide 3-kinase inhibitor ( wortmannin )
suppressed the expression of
Rad51 and enhanced the erlotinib induced cell death in erlotinib-resistant cells
Mancini et al., J Cell Biochem 2010
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Moreover,
RAD 001 induced
inhibition of
Akt causes the de-phosphorylation of tuberous sclerosis tumor suppressor protein TSC2 at 14-3-3 binding sites, TSC2 release from 14-3-3 sigma ( restoring its inhibitory function on mTORC1 ) and nuclear import ( promoting the nuclear translocation of cyclin dependent kinase [ CDK ] inhibitor p27 ( Kip1 ), the stabilization of p27 ( Kip1 ) ligand with CDK2, and the G ( 0 ) /G ( 1 ) arrest )
Tsai et al., J Pharmacol Exp Ther 2010
(Carcinoma, Non-Small-Cell Lung) :
Enforced expression of constitutively active MKK1/2 or
AKT recovered cell viability and
Rad51 protein levels that were decreased by the combination of erlotinib and gemcitabine
Loehberg et al., Biochem Pharmacol 2012
(Breast Neoplasms...) :
The anticancer drug
RAD001 ( everolimus ) is a known mTOR-inhibitor, but mTOR-inhibition
leads to phosphorylation of
Akt inducing resistance against RAD001 treatment ... Therefore, our aim was to test, if Chloroquine could inhibit tumor growth and prevent
RAD001 induced
Akt activation ... The Chloroquine effect of overcoming the
RAD001 induced activation of the oncogene
Akt , as well as the promising antitumor activity in our mammary tumor animal model present Chloroquine as an interesting combination partner for the mTOR-inhibitor RAD001
Ren et al., Cancer Lett 2012
(Carcinoma, Non-Small-Cell Lung...) :
This combination abrogated
RAD001 induced
Akt phosphorylation and exerted enhanced suppressive effect on 4EBP1 phosphorylation
Chan et al., Cancer Chemother Pharmacol 2013
(Carcinoma, Hepatocellular...) :
Although the addition of the TKI258 only slightly suppressed the phosphorylation of
AKT induced by
RAD001 , the pi-mTOR and its downstream signaling pathways including pi-p70S6K, pi-S6 and pi-4EBP1 were lowered in the combination
Hisamatsu et al., Mol Cancer Ther 2013
:
Treatment with
RAD001 induced mTORC2 mediated
AKT activation in RAD001-sensitive CCC cells