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EPHB2 — RASGRP1
Text-mined interactions from Literome
Ebinu et al., Blood 2000
:
Overexpression of
RasGRP in T cells
enhanced TCR-Ras-Erk signaling and augmented interleukin-2 secretion in response to calcium ionophore plus DAG analogues phorbol ester myristate or bryostatin-1
Keiper et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
In line with this hypothesis, receptor mediated activation of H-Ras and
ERK1/2 was strongly
enhanced by expression of
RasGRP1 , a Ca2+ -regulated Ras-GEF
Han et al., Mol Pharmacol 2007
(Lymphoma) :
Transfection of
RasGRP1 into resistant cells
enhances PMA induced
Erk activation
Ko et al., American journal of physiology. Renal physiology 2010
:
Furthermore, ubiquitination of NCC is essential for this process and this ubiquitination is dependent upon
RasGRP1 mediated
ERK1/2 activation
Warnecke et al., EMBO Rep 2012
:
We found that T-cell antigen receptor ( TCR ) -mediated
Erk activation
requires RasGRP1 , but not Grb2/Sos
Golec et al., PloS one 2013
(MAP Kinase Signaling System) :
RasGRP1 , but Not RasGRP3, Is
Required for Efficient Thymic ß-Selection and
ERK Activation Downstream of CXCR4 ... Also, we report that
RasGRP1 is
required for
ERK activation downstream of CXCR4 signaling, which we hypothesize represents a potential mechanism of RasGRP1 regulation of ß-selection
Jun et al., Mol Cell Biol 2013
(MAP Kinase Signaling System) :
We previously described how
RasGRP alone
induces analog
Ras-ERK activation while SOS and RasGRP cooperate to establish bimodal ERK activation