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EPHB2 — RASGRP1

Text-mined interactions from Literome

Ebinu et al., Blood 2000 : Overexpression of RasGRP in T cells enhanced TCR-Ras-Erk signaling and augmented interleukin-2 secretion in response to calcium ionophore plus DAG analogues phorbol ester myristate or bryostatin-1
Keiper et al., J Biol Chem 2004 (MAP Kinase Signaling System) : In line with this hypothesis, receptor mediated activation of H-Ras and ERK1/2 was strongly enhanced by expression of RasGRP1 , a Ca2+ -regulated Ras-GEF
Han et al., Mol Pharmacol 2007 (Lymphoma) : Transfection of RasGRP1 into resistant cells enhances PMA induced Erk activation
Ko et al., American journal of physiology. Renal physiology 2010 : Furthermore, ubiquitination of NCC is essential for this process and this ubiquitination is dependent upon RasGRP1 mediated ERK1/2 activation
Warnecke et al., EMBO Rep 2012 : We found that T-cell antigen receptor ( TCR ) -mediated Erk activation requires RasGRP1 , but not Grb2/Sos
Golec et al., PloS one 2013 (MAP Kinase Signaling System) : RasGRP1 , but Not RasGRP3, Is Required for Efficient Thymic ß-Selection and ERK Activation Downstream of CXCR4 ... Also, we report that RasGRP1 is required for ERK activation downstream of CXCR4 signaling, which we hypothesize represents a potential mechanism of RasGRP1 regulation of ß-selection
Jun et al., Mol Cell Biol 2013 (MAP Kinase Signaling System) : We previously described how RasGRP alone induces analog Ras-ERK activation while SOS and RasGRP cooperate to establish bimodal ERK activation