Gene interactions and pathways from curated databases and text-mining

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AKT1 — RNF19A

Text-mined interactions from Literome

Marushige et al., Anticancer Res 1999 (MAP Kinase Signaling System...) : The p38 inhibitor, PD169316, reduced the activities of ERK and Akt
Bijur et al., J Neurochem 2000 : Akt activation was not blocked by inhibition of p38 or ERK1/2, indicating the independence of these signaling systems
Gratton et al., J Biol Chem 2001 : Conversely, activation-deficient Akt decreases VEGF stimulated MEKK3 phosphorylation and increases MKK/p38 activation
Souza et al., Mol Med 2001 (MAP Kinase Signaling System) : Interestingly, however, SB203580, a known p38 inhibitor, completely inhibited arsenite induced phosphorylation of AKT and eNOS
Kettritz et al., J Am Soc Nephrol 2002 : p38 MAPK inhibition with 10 microM SB202190 that also decreased ANCA induced superoxide generation prevented S473 phosphorylation of Akt in response to TNF-alpha and to ANCA
Baudhuin et al., Mol Pharmacol 2002 : However, epidermal growth factor, thrombin, and endothelin-1 stimulated Akt S473 phosphorylation require p38 but not MEK ... MEK and p38 activation were sufficient for Akt S473 but not T308 phosphorylation in HEY cells
Gonzalez et al., Mol Cell Biol 2004 (MAP Kinase Signaling System) : Inhibition or activation of p38 with SB203580, dominant negative p38, or MKK6EE regulated Akt kinase activity
Taniyama et al., Am J Physiol Cell Physiol 2004 (MAP Kinase Signaling System) : Inhibition of p38 MAPK activity with SB-203580 dose-dependently inhibits Akt phosphorylation on Ser ( 473 ), but not Thr ( 308 )
Hornberger et al., J Cell Biochem 2006 : In comparison to vehicle treated controls, both nutrient and mechanical stimuli induced P-p70 ( 389 ), neither stimulus altered P-PKB or P-mTOR ( 2481 ), and only mechanical stimuli induced P-p38
Grethe et al., Biochem Biophys Res Commun 2006 : Notably, we also found that doxorubicin provoked apoptosis included p38 MAPK mediated inhibition of Akt and Bad phosphorylation
Naïmi et al., Endocrinology 2007 (MAP Kinase Signaling System) : In contrast, Foxo1-ADA increases p38 activity, and p38 is required for effects of Foxo1 on PKB , at least in part
Liu et al., J Biol Chem 2007 (Insulin Resistance) : Our results show that a prolonged treatment of primary hepatocytes with oleate blunted insulin suppression of hepatic gluconeogenesis, and decreased insulin induced phosphorylation of Akt in a p38 dependent manner
Diehl et al., J Surg Res 2007 (Breast Neoplasms...) : We also found that AKT was activated by p38MAPK in these cells, but this activation did not play a role in invasion
Ogunwobi et al., Am J Gastroenterol 2008 (Adenocarcinoma...) : Simvastatin inhibited activation of extracellular signal regulated kinase ( ERK ) and protein kinase B ( Akt ) but not c-Jun NH ( 2 ) -terminal kinase or p38 mitogen activated protein ( MAP ) kinase ... Simvastatin inhibited activation of extracellular signal regulated kinase ( ERK ) and protein kinase B ( Akt ) but not c-Jun NH ( 2 ) -terminal kinase or p38 mitogen activated protein ( MAP ) kinase
Hong et al., J Exp Clin Cancer Res 2009 (Carcinoma, Squamous Cell...) : Inhibition of Akt activity by PIA decreased NF-kappaB signaling, but did not affect phosphorylation of ERK, JNK, and p38 in KB and KOSCC-25B cells
Rane et al., American journal of physiology. Renal physiology 2010 (Diabetes Mellitus, Experimental...) : These results collectively suggest that downregulation of Akt activation during long-term hyperglycemia contributes to enhanced p38 MAPK activation and RPTC apoptosis
Bulzomi et al., IUBMB Life 2010 (Neoplasms, Hormone-Dependent) : In contrast, Nar stimulation prevents E2-induced extracellular regulated kinases ( ERK1/2 ) and AKT activation and still induces the activation of p38 , the proapoptotic member of mitogen activating protein kinase ( MAPK ) family
Aceros et al., Br J Pharmacol 2011 (Fibrosis...) : In vitro, moxonidine inhibited norepinephrine induced neonatal cardiomyocyte mortality but increased fibroblast mortality, through I ( 1 ) -receptor activation and differential effects on downstream Akt and p38 MAPK
Valente et al., Cell Signal 2012 (Fibrosis...) : These results indicate that IL-17A stimulates CF proliferation and migration via Akt/miR-101/MKP-1 dependent p38 MAPK and ERK1/2 activation
Suwanabol et al., Am J Physiol Heart Circ Physiol 2012 (Carotid Artery Injuries) : Furthermore, inhibition of p38 in vivo led to decreased Akt phosphorylation and SMC proliferation
Yamawaki et al., Biochem Biophys Res Commun 2012 (Inflammation) : The effect is mediated via inhibiting activation of NF-?B and p38 through stimulation of Akt/eNOS signaling and NO production