Gene interactions and pathways from curated databases and text-mining

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INS — RPS10

Text-mined interactions from Literome

Proud et al., Biochem Soc Trans 2006 : Insulin also stimulates synthesis of ribosomal proteins by promoting recruitment of their mRNAs into polyribosomes
Miranda et al., Pflugers Arch 2008 : Insulin , on the other hand, stimulated protein synthesis ( by 30 % ) and increased p70 ribosomal protein S6 kinase (p70S6K) Thr389, 40S ribosomal protein S6 ( rpS6 ) Ser235/236, rpS6 Ser240/244 and eukaryotic initiation factor-4E binding protein-1 (4E-BP1) Thr37/46 phosphorylation over basal values
Deshmukh et al., Mol Endocrinol 2008 : Insulin stimulation increased phosphorylation of S6K1 ( Thr389 ), ribosomal protein S6 ( Ser235/236 ), and 4E-BP1 ( Thr37/46 ) ( P < 0.01 ) in WT, AMPK alpha2 KO, and AMPK gamma3 KO mice
Villa-Hernández et al., Biochimie 2013 : Insulin increased this synthesis ( 75 % ) at 24 h of imbibition ; however, not all ribosomal proteins were similarly regulated
Nemenoff et al., Arch Biochem Biophys 1986 (Liver Neoplasms, Experimental) : Insulin stimulates the phosphorylation of the 40 S ribosomal subunit protein, S6, in intact 32P labeled H4IIE-C3 cells, a rat hepatoma line
Morgan et al., Proc Natl Acad Sci U S A 1987 : Injection of this inhibitory antibody resulted in a decreased ability of insulin to stimulate the uptake of 2-deoxyglucose in Chinese hamster ovary cells and freshly isolated rat adipocytes, ribosomal protein S6 phosphorylation in CHO cells, and glycogen synthesis in the human hepatoma cell line HepG2
Kulkarni et al., Biochim Biophys Acta 1983 (Melanoma...) : In the hybrid cells, under conditions of growth arrest in medium with low serum, ribosomal protein S6 was rapidly phosphorylated in response to insulin or serum
von Manteuffel et al., Mol Cell Biol 1997 : Employing specific inhibitors and docking-site mutants of growth factor receptors, recent studies have indicated that the insulin induced increase in 40S ribosomal protein S6 and initiation factor 4E binding protein 1 (4E-BP1) phosphorylation is mediated by the mTOR/FRAP-p70s6k signal transduction pathway