Gene interactions and pathways from curated databases and text-mining

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HIF1A — RPTOR

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Toschi et al., J Biol Chem 2008 : HIF1 alpha expression was dependent on both Raptor ( a constituent of mTORC1 ) and Rictor ( a constitutive of mTORC2 ) ... These data indicate that although HIF1 alpha is dependent on both mTORC1 and mTORC2, HIF2 alpha is dependent only on mTORC2
Pistollato et al., PloS one 2009 (Brain Neoplasms...) : Here, we investigate the role of mTOR signaling in the regulation of HIF-1alpha stability in primary GBM derived cells maintained under hypoxia ( 2 % oxygen )
Ji et al., Mol Pharmacol 2010 : Stimulation of endogenous EP1 receptors in human HepG2 hepatocellular carcinoma cells recapitulated the normoxic up-regulation of HIF-1 alpha observed in HEK cells, was sensitive to pertussis toxin, and involved the activation of mTOR signaling and phosphorylation of rpS6