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PI3 — RRAS
Text-mined interactions from Literome
Kwong et al., Mol Cell Biol 2003
:
R-Ras effector domain mutants and pharmacological inhibition suggest a partial
role for
phosphatidylinositol 3-kinase (PI3K) , but not Raf, in
R-Ras signaling to FAK and p130 ( Cas )
Wozniak et al., Mol Biol Cell 2005
:
The effects of
R-Ras on cell migration are
mediated by
PI3-Kinase , as an effector mutant that uncouples PI3-Kinase binding from R-Ras ( 38V ) rescued migration
Wurtzel et al., Small GTPases 2012
:
Finally, palmitoylation-deficient
R-Ras blocked membrane ruffling,
R-Ras/PI3-kinase interaction, enrichment of PtdIns ( 3,4,5 ) P ( 3 ) at the plasma membrane, and R-Ras dependent cell spreading
Marte et al., Curr Biol 1997
(Cell Transformation, Neoplastic) :
In co-transfection assays, the serine/threonine protein kinase PKB ( or Akt ) is effectively stimulated by
R-Ras , Ras, mutants of Ras that activate PI 3-kinase but not other effectors, and
activated forms of
PI 3-kinase