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IL2 — SETBP1
Text-mined interactions from Literome
Hartung et al., J Hematother Stem Cell Res 1999
(HIV Infections) :
Blood from HIV infected patients at advanced stages of disease showed reduced
interleukin (IL)-2 formation in
response to
staphylococcal exotoxin B (SEB) , which was restored in the presence of Filgrastim
Lehnert et al., Biochemistry 2001
:
Finally, we show that DRalpha- ( GSTAPPA ) ( 2 ) -TCRVbeta inhibits
SEB induced
IL-2 release and T cell proliferation at nanomolar concentrations
Komisar et al., Toxicol Pathol 2001
(Shock, Septic) :
All monkeys made
IL-2 , TNF, and IFN-gamma in
response to
SEB
Sweeney et al., Eur J Vasc Endovasc Surg 2002
(Aortic Aneurysm, Abdominal) :
peripheral T-cell expression of surface markers CD69, CD62L and CD25 in vivo and
Interleukin 2 (IL-2) and Interleukin-10 (IL-10)
responses to the superantigen
staphylococcal enterotoxin B (SEB) in vitro were measured preoperatively, 24 h and 1 week postoperatively ... Enhanced T cell activation occurred following C-AAA and this was associated with significantly greater
IL-2 production in
response to
SEB , with no change in IL-10 production
Sweeney et al., Br J Surg 2003
(Acute Disease...) :
The production of interleukin (IL) 10 and
IL-2 in vitro in
response to the superantigen
Staphylococcus enterotoxin B (SEB) was assessed ... There was a significant increase in the production of
SEB induced
IL-2 compared with findings in controls, but no significant IL-10 response
Hisano et al., Arch Dermatol Res 2003
(Dermatitis, Atopic) :
Furthermore, EGCg inhibited
SEB induced TNF-alpha and IFN- gamma production and
IL-2 , IFN-gamma, IL-10 and IL-12 p40 mRNA expression in human PBMCs from normal donors in a dose dependent manner
Kruse et al., J Interferon Res 1992
:
In the
presence of
SEB , cord blood cells produced
interleukin-2 (IL-2) and significant amounts of IFN-gamma
Ragin et al., BMC immunology 2005
(MAP Kinase Signaling System) :
A role for the Tec family kinase ITK in regulating
SEB induced
interleukin-2 production in vivo via c-jun phosphorylation ... These data show that ITK is required for
IL-2 production
induced by
SEB in vivo, and may regulate signals leading IL-2 production, in part by regulating phosphorylation of c-jun
Watson et al., Cell Immunol 2005
:
Pretreatment or co-treatment of human PBMC or murine lymphnode cells with EGCG significantly reduced
SEB induced proliferation and
IL-2 , IFNgamma, and TNFalpha production
Amat et al., Br J Pharmacol 2006
(Arthritis) :
Compound J-113863 was tested in collagen induced arthritis ( CIA ) and three models of acute inflammation ;
Staphylococcus enterotoxin B (SEB) induced
interleukin-2 (IL-2) , delayed-type hypersensitivity ( DTH ) response, and lipopolysaccharide (LPS) induced tumour necrosis factoralpha (TNFalpha) production
Hayworth et al., Clin Exp Immunol 2009
(Staphylococcal Infections) :
Here, we report that bovine LF ( bLF ) was indeed able to attenuate
SEB induced proliferation,
interleukin-2 production and CD25 expression by human leucocyte antigen ( HLA ) -DR4 transgenic mouse T cells
Krakauer et al., Mediators Inflamm 2010
(Hypothermia...) :
In vivo,
SEB alone
induced moderate levels of
IL-2 and MCP-1 and all mice survived even with a high dose of SEB ( 100 microg/mouse )
Yokomizo et al., J Vet Med Sci 1995
:
SEA,
SEB , SEC and TSST-1, all
induced the in vitro release of
interleukin-2 , interferon gamma and tumor necrosis factor alpha in a dose dependent manner
Blankson et al., Cell Immunol 1994
:
We show that either the addition of anti-CD28 monoclonal antibody or presentation with a B7 transfected cell line enhances the proliferative and
interleukin-2 secretion
response of DO11.10 CD4+ cells to both the conventional antigen, ovalbumin peptide ( OVA 323-339 ), and the superantigen
SEB
Sperber et al., Clin Diagn Lab Immunol 1995
:
SEB similarly
induced no
IL-2 or gamma interferon from the LPL, but IL-4, IL-6, and TNF were detected ... In IEL, SEE
induced no
IL-2 , IL-4, or gamma interferon but produced IL-6 and TNF, while
SEB stimulation resulted in no IL-2 or gamma interferon but did result in detectable IL-4, IL-6, and TNF
Nakata et al., J Immunol 1995
:
When rhIL-1 was administered within 24 h after SEB inoculation, the cytokine interfered with tolerance induction ; V beta 8+CD4 T cells from mice that had been treated with both SEB and IL-1 proliferated in
response to
SEB and produced
IL-2 , IL-4, and IFN-gamma upon TCR/CD28 cross linking
Florquin et al., Eur J Immunol 1995
:
The superantigen
staphylococcal enterotoxin B (SEB) induces a defect in
interleukin (IL)-2 production by T cells expressing specific T cell receptor V beta domains
Origuchi et al., Clin Exp Immunol 1995
(Arthritis, Rheumatoid...) :
In the presence of IFN-gamma treated synovial cells, T cells proliferated vigorously and produced
IL-2 in
response to
SEB
Prado et al., Braz J Med Biol Res 1995
(Uremia) :
T cell activity was evaluated in vitro by lymphocyte proliferation and
interleukin 2 (IL 2) production in
response to the super antigen
staphylococcal enterotoxin B (SEB)
Kuschnaroff et al., Scand J Immunol 1997
:
However,
SEB induced
IL-2 and IL-10 mRNA expression was suppressed only by CsA, whereas tumour necrosis factor-alpha (TNF-alpha) was decreased only by anti-IFN-gamma Abs
Weng et al., Int Immunol 1997
:
The first pattern, characterized by the responses of all T cells, HLA-DRlo cells, monocytes,
IL-2R+ cells, IFN-gamma, and augmented lymphocyte mitotic
responses to lipopolysaccharide (LPS) and
SEB in culture, was a rapid increase at 20 min followed by a quick decrease at 90 min to approximately the original levels
Huang et al., Int J Immunopharmacol 1998
(Body Weight) :
Both the kinetics and extent of
SEB induced
IL-2 receptor (IL-2R) and T-cell receptor ( TCR ) expression on CD4+ cells was unaffected by TCDD
Hartung et al., J Infect Dis 1998
(Disease Progression...) :
Patients with advanced HIV infection showed reduced
IL-2 and IL-4 release in the
presence of
SEB
Perrin et al., Blood 1999
:
Associated with the inhibition of the cell cycle, IL-10 suppressed
SEB induction of
interleukin-2 (IL-2)
Soltys et al., Infect Immun 1999
:
In vitro stimulation of lymphocytes isolated from soluble beta-glucan treated mice with lipopolysaccharide (LPS) resulted in enhanced production of interleukin-6 (IL-6) and suppressed production of tumor necrosis factor alpha (TNF-alpha), while stimulation of these cells with
staphylococcal enterotoxin B (SEB) or toxic shock syndrome toxin 1 ( TSST-1 ) resulted in enhanced production of gamma interferon ( IFN-gamma ) and
suppressed production of
IL-2 and TNF-alpha compared to that in cells isolated from untreated mice