Gene interactions and pathways from curated databases and text-mining

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IL2 — SETBP1

Text-mined interactions from Literome

Hartung et al., J Hematother Stem Cell Res 1999 (HIV Infections) : Blood from HIV infected patients at advanced stages of disease showed reduced interleukin (IL)-2 formation in response to staphylococcal exotoxin B (SEB) , which was restored in the presence of Filgrastim
Lehnert et al., Biochemistry 2001 : Finally, we show that DRalpha- ( GSTAPPA ) ( 2 ) -TCRVbeta inhibits SEB induced IL-2 release and T cell proliferation at nanomolar concentrations
Komisar et al., Toxicol Pathol 2001 (Shock, Septic) : All monkeys made IL-2 , TNF, and IFN-gamma in response to SEB
Sweeney et al., Eur J Vasc Endovasc Surg 2002 (Aortic Aneurysm, Abdominal) : peripheral T-cell expression of surface markers CD69, CD62L and CD25 in vivo and Interleukin 2 (IL-2) and Interleukin-10 (IL-10) responses to the superantigen staphylococcal enterotoxin B (SEB) in vitro were measured preoperatively, 24 h and 1 week postoperatively ... Enhanced T cell activation occurred following C-AAA and this was associated with significantly greater IL-2 production in response to SEB , with no change in IL-10 production
Sweeney et al., Br J Surg 2003 (Acute Disease...) : The production of interleukin (IL) 10 and IL-2 in vitro in response to the superantigen Staphylococcus enterotoxin B (SEB) was assessed ... There was a significant increase in the production of SEB induced IL-2 compared with findings in controls, but no significant IL-10 response
Hisano et al., Arch Dermatol Res 2003 (Dermatitis, Atopic) : Furthermore, EGCg inhibited SEB induced TNF-alpha and IFN- gamma production and IL-2 , IFN-gamma, IL-10 and IL-12 p40 mRNA expression in human PBMCs from normal donors in a dose dependent manner
Kruse et al., J Interferon Res 1992 : In the presence of SEB , cord blood cells produced interleukin-2 (IL-2) and significant amounts of IFN-gamma
Ragin et al., BMC immunology 2005 (MAP Kinase Signaling System) : A role for the Tec family kinase ITK in regulating SEB induced interleukin-2 production in vivo via c-jun phosphorylation ... These data show that ITK is required for IL-2 production induced by SEB in vivo, and may regulate signals leading IL-2 production, in part by regulating phosphorylation of c-jun
Watson et al., Cell Immunol 2005 : Pretreatment or co-treatment of human PBMC or murine lymphnode cells with EGCG significantly reduced SEB induced proliferation and IL-2 , IFNgamma, and TNFalpha production
Amat et al., Br J Pharmacol 2006 (Arthritis) : Compound J-113863 was tested in collagen induced arthritis ( CIA ) and three models of acute inflammation ; Staphylococcus enterotoxin B (SEB) induced interleukin-2 (IL-2) , delayed-type hypersensitivity ( DTH ) response, and lipopolysaccharide (LPS) induced tumour necrosis factoralpha (TNFalpha) production
Hayworth et al., Clin Exp Immunol 2009 (Staphylococcal Infections) : Here, we report that bovine LF ( bLF ) was indeed able to attenuate SEB induced proliferation, interleukin-2 production and CD25 expression by human leucocyte antigen ( HLA ) -DR4 transgenic mouse T cells
Krakauer et al., Mediators Inflamm 2010 (Hypothermia...) : In vivo, SEB alone induced moderate levels of IL-2 and MCP-1 and all mice survived even with a high dose of SEB ( 100 microg/mouse )
Yokomizo et al., J Vet Med Sci 1995 : SEA, SEB , SEC and TSST-1, all induced the in vitro release of interleukin-2 , interferon gamma and tumor necrosis factor alpha in a dose dependent manner
Blankson et al., Cell Immunol 1994 : We show that either the addition of anti-CD28 monoclonal antibody or presentation with a B7 transfected cell line enhances the proliferative and interleukin-2 secretion response of DO11.10 CD4+ cells to both the conventional antigen, ovalbumin peptide ( OVA 323-339 ), and the superantigen SEB
Sperber et al., Clin Diagn Lab Immunol 1995 : SEB similarly induced no IL-2 or gamma interferon from the LPL, but IL-4, IL-6, and TNF were detected ... In IEL, SEE induced no IL-2 , IL-4, or gamma interferon but produced IL-6 and TNF, while SEB stimulation resulted in no IL-2 or gamma interferon but did result in detectable IL-4, IL-6, and TNF
Nakata et al., J Immunol 1995 : When rhIL-1 was administered within 24 h after SEB inoculation, the cytokine interfered with tolerance induction ; V beta 8+CD4 T cells from mice that had been treated with both SEB and IL-1 proliferated in response to SEB and produced IL-2 , IL-4, and IFN-gamma upon TCR/CD28 cross linking
Florquin et al., Eur J Immunol 1995 : The superantigen staphylococcal enterotoxin B (SEB) induces a defect in interleukin (IL)-2 production by T cells expressing specific T cell receptor V beta domains
Origuchi et al., Clin Exp Immunol 1995 (Arthritis, Rheumatoid...) : In the presence of IFN-gamma treated synovial cells, T cells proliferated vigorously and produced IL-2 in response to SEB
Prado et al., Braz J Med Biol Res 1995 (Uremia) : T cell activity was evaluated in vitro by lymphocyte proliferation and interleukin 2 (IL 2) production in response to the super antigen staphylococcal enterotoxin B (SEB)
Kuschnaroff et al., Scand J Immunol 1997 : However, SEB induced IL-2 and IL-10 mRNA expression was suppressed only by CsA, whereas tumour necrosis factor-alpha (TNF-alpha) was decreased only by anti-IFN-gamma Abs
Weng et al., Int Immunol 1997 : The first pattern, characterized by the responses of all T cells, HLA-DRlo cells, monocytes, IL-2R+ cells, IFN-gamma, and augmented lymphocyte mitotic responses to lipopolysaccharide (LPS) and SEB in culture, was a rapid increase at 20 min followed by a quick decrease at 90 min to approximately the original levels
Huang et al., Int J Immunopharmacol 1998 (Body Weight) : Both the kinetics and extent of SEB induced IL-2 receptor (IL-2R) and T-cell receptor ( TCR ) expression on CD4+ cells was unaffected by TCDD
Hartung et al., J Infect Dis 1998 (Disease Progression...) : Patients with advanced HIV infection showed reduced IL-2 and IL-4 release in the presence of SEB
Perrin et al., Blood 1999 : Associated with the inhibition of the cell cycle, IL-10 suppressed SEB induction of interleukin-2 (IL-2)
Soltys et al., Infect Immun 1999 : In vitro stimulation of lymphocytes isolated from soluble beta-glucan treated mice with lipopolysaccharide (LPS) resulted in enhanced production of interleukin-6 (IL-6) and suppressed production of tumor necrosis factor alpha (TNF-alpha), while stimulation of these cells with staphylococcal enterotoxin B (SEB) or toxic shock syndrome toxin 1 ( TSST-1 ) resulted in enhanced production of gamma interferon ( IFN-gamma ) and suppressed production of IL-2 and TNF-alpha compared to that in cells isolated from untreated mice