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RELA — SETD2

Text-mined interactions from Literome

Figueroa et al., Exp Hematol 2002 (Anoxia) : The selective inhibitor of NF-kappaB , pyrrolidine dithiocarbamate ( PDTC ), significantly blocked HIF-1 protein expression ... Inhibition of NF-kappaB with a superrepressor dominant negative IkappaBalpha genetic construct also significantly blocked NF-kappaB and HIF-1 transactivation, as well as EPO gene expression
Tacchini et al., Carcinogenesis 2004 (Breast Neoplasms...) : Hepatocyte growth factor activated NF-kappaB regulates HIF-1 activity and ODC expression, implicated in survival, differently in different carcinoma cell lines
Nishi et al., Antioxid Redox Signal 2008 : LPS mediated activation of HIF-1 was independent of NF-kappaB activity
Scortegagna et al., Blood 2008 (Drug Hypersensitivity...) : HIF-1 induced NFkappaB activation was composed of 2 elements, IkappaB hyperphosphorylation and phosphorylation of Ser276 on p65, enhancing p65 nuclear localization and transcriptional activity, respectively
Bendinelli et al., Mol Cancer Res 2009 (Bone Neoplasms...) : NF-kappaB activation, dependent on acetylation/deacetylation, contributes to HIF-1 activity and migration of bone metastatic breast carcinoma cells
Kumar et al., PloS one 2012 : Inhibition of TG2 or p65/RelA also inhibited the HIF-1a expression and attenuated Zeb1, Zeb2, and Twist expression
Tafani et al., Frontiers in pharmacology 2013 : Interestingly, hypoxia and inflammation have been sequentially bridged in tumors by the discovery that alarmin receptors genes such as RAGE, P2X7, and some TLRs, are activated by HIF1a ; and that, in turn, alarmin receptors strongly activate NFkB and proinflammatory gene expression, evidencing all the hallmarks of the malignant phenotype