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MAPK12 — SMAD2
Text-mined interactions from Literome
Wrana et al., Science's STKE : signal transduction knowledge environment 2000
:
In the cytosol,
Smad translocation might be
inhibited by
mitogen activated protein kinase dependent phosphorylation, whereas in the nucleus Smads interact with a number of transcription factors that themselves are primary targets of other signaling pathways
Rhyu et al., J Am Soc Nephrol 2005
(Fibrosis...) :
Chemical inhibition of ERK but not p38 MAPK inhibited TGF-beta1 induced
Smad 2 phosphorylation, and both
MAPK inhibitors
inhibited TGF-beta1- and H ( 2 ) O ( 2 ) -induced EMT
Galliher et al., Cancer Res 2007
(MAP Kinase Signaling System...) :
Interestingly, although the expression of Y284F-TbetaR-II mutants in breast cancer cells had no effect on TGF-beta stimulation of
Smad2/3 , this TbetaR-II mutant completely abrogated p38
MAPK activation by TGF-beta
Zhao et al., Mol Cell Biochem 2008
(Fibrosis...) :
Additionally, the inhibition of
MAPK signaling
had no effect on
Smad activation elicited by chymase
Zhang et al., Exp Dermatol 2009
(Fibrosis) :
Activation of
Smad2 required p38
MAPK but not p42/p44 MAPK or the epidermal growth factor receptor
Zhu et al., Prostate 2010
(MAP Kinase Signaling System) :
These findings suggest a dual role for PHB as a downstream determinant of the cellular response to TGF-beta via
Smad dependent pathway ( apoptosis ) and
MAPK intracellular signaling ( survival )
Rodrigues Díez et al., PloS one 2010
(Fibrosis) :
In cultured rat VSMCs, direct
AngII/Smad pathway activation was
mediated by p38
MAPK and ROCK activation
Ungefroren et al., Int J Oncol 2011
(Carcinoma, Pancreatic Ductal...) :
Biochemically, dnSrc inhibition failed to block TGF-ß1/ALK5 induced activation of Smad2 and Smad3, but partially
inhibited transcriptional activation of
TGF-ß/Smad-responsive reporter genes, and effectively blocked basal and TGF-ß1 induced activation of p38
MAPK
Mottershead et al., Mol Hum Reprod 2012
:
The GDF9/BMP15 synergistic signalling response was inhibited by the
SMAD2/3 phosphorylation inhibitor SB431542, as well as
inhibition of the
mitogen activated protein kinase or rous sarcoma oncogene (SRC) signalling pathways, but not the nuclear factor kappa B pathway