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HIF1A — SP1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SP1 → HIF1A (increases, HIF1A Activity)
  Evidence: HIF1 is reported to release the transcription factor Sp1, which is required for MYC promoter activation, and this inhibits the MYC-stimulated targets MSH2, MSH6 and Nijmegen breakage syndrome 1 (also known as NBN), which are all involved in the DNA-damage response41,42.
• FastForward regulation: SP1 → HIF1A (transcriptional regulation, unknown)
  Evidence: DNABINDING, PROMACTIVITY
• FastForward regulation: SP1 → HIF1A (transcriptional regulation, increase) Minet et al., Biochem Biophys Res Commun 1999*
  Evidence: DNABINDING, PROMACTIVITY
• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A/ARNT/SMAD3/SMAD4/SP1 complex (HIF1A-ARNT-SMAD3-SMAD4-SP1) → SMAD3/SMAD4 complex (SMAD3-SMAD4) (modification, collaborate)
  Sánchez-Elsner et al., J Biol Chem 2002
  Evidence: physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A/ARNT/SMAD3/SMAD4/SP1 complex (HIF1A-ARNT-SMAD3-SMAD4-SP1) → SP1 (SP1) (modification, collaborate) Sánchez-Elsner et al., J Biol Chem 2002
  Evidence: physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A/ARNT/SMAD3/SMAD4/SP1 complex (HIF1A-ARNT-SMAD3-SMAD4-SP1) → HIF1A/ARNT complex (HIF1A-ARNT) (modification, collaborate)
  Sánchez-Elsner et al., J Biol Chem 2002
  Evidence: physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: SP1 (SP1) → HIF1A/ARNT complex (HIF1A-ARNT) (modification, collaborate)
  Sánchez-Elsner et al., J Biol Chem 2002
  Evidence: physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: SP1 (SP1) → HIF1A/ARNT complex (HIF1A-ARNT) (transcription, activates)
  Comerford et al., Cancer Res 2002*
  Evidence: mutant phenotype

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: HIF1A — SP1 (coimmunoprecipitation) Koshiji et al., Mol Cell 2005*
• IRef Biogrid Interaction: HIF1A — SP1 (colocalization, imaging technique) Koshiji et al., Mol Cell 2005*
• IRef Biogrid Interaction: HIF1A — SP1 (direct interaction, pull down) Koshiji et al., Mol Cell 2005*
• IRef Biogrid Interaction: HIF1A — SP1 (physical association, affinity chromatography technology) Sánchez-Elsner et al., J Biol Chem 2002
• IRef Biogrid Interaction: HIF1A — SP1 (direct interaction, pull down) To et al., EMBO J 2006*
• IRef Biogrid Interaction: HIF1A — SP1 (physical association, affinity chromatography technology) To et al., EMBO J 2006*
• IRef Hprd Interaction: HIF1A — SP1 (in vivo) To et al., EMBO J 2006*, Gordan et al., Cancer Cell 2007
• IRef Intact Interaction: HIF1A — SP1 (physical association, anti bait coimmunoprecipitation) To et al., EMBO J 2006*
• IRef Intact Interaction: HIF1A — SP1 (physical association, competition binding) To et al., EMBO J 2006*

Text-mined interactions from Literome

Oh et al., Neurosci Lett 2008 (Anoxia) : Taken together, these results suggest that LPS induces HIF-1alpha mRNA expression and activation via NADPH oxidase and Sp1 in BV2 microglia
Tai et al., J Neurochem 2009 : These findings are the first to suggest that hypoxia activates the proximal rat PNMT promoter primarily via HIF1alpha induction of Egr-1 and Sp1 rather than by co-activation by Egr-1, Sp1 and HIF1alpha
Koshikawa et al., J Biol Chem 2009 (Carcinoma, Lewis Lung) : The up-regulation of HIF-1alpha transcription was abolished by mithramycin A, an Sp1 inhibitor, but luciferase reporter and chromatin immunoprecipitation assays indicated that Sp1 was necessary but not sufficient for HIF-1alpha mRNA overexpression in A11 cells