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PIK3R1 — SST
Text-mined interactions from Literome
Pola et al., J Biol Chem 2003
(MAP Kinase Signaling System...) :
Although
somatostatin does not
affect PI3-K , it inhibits ERK 1/2 and the small G-protein Rac activation and ruffle formation induced by PDGF
Bousquet et al., EMBO J 2006
(Neoplasms, Experimental) :
Somatostatin , acting through sst2,
inhibits PI3K activity by disrupting a pre existing complex comprising the sst2 receptor and the p85 PI3K regulatory subunit ... Mutating sst2-Y71 disabled sst2 to interact with p85 and
somatostatin to
inhibit PI3K , consequently abrogating sst2 's ability to suppress cell survival and tumor growth