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IFNG — STAT6
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Dickensheets et al., J Leukoc Biol 1999
:
Because STAT6 activation plays an essential role in IL-4/IL-13 induced gene expression, the ability of IFN-beta and
IFN-gamma to
inhibit STAT6 activity provides an explanation for how IFNs can suppress IL-4/IL-13-inducible gene expression
Venkataraman et al., J Immunol 1999
:
IFN-gamma stimulation
results in a loss of IL-4 induced
Stat6 tyrosine phosphorylation, nuclear translocation, and DNA binding
Moffatt et al., Transplantation 2000
:
Interferon-gamma activates STAT1, a TH1-type mediator, and interleukin-4
activates STAT6 , a TH2-type mediator
Strait et al., J Immunol 2003
(Anaphylaxis...) :
This effect was inhibited by endogenously produced
IFN-gamma , was T cell-, B cell-, and common gamma-chain independent, and
required IL-4Ralpha and
Stat6
Sato et al., Biochem Biophys Res Commun 2004
:
In SOCS-1 ( -/- ) MEF,
IFN-gamma inhibited neither
STAT6 phosphorylation nor eotaxin production induced by IL-4 and TNF-alpha ... Thus, we demonstrated that
IFN-gamma induced inhibition of
STAT6 phosphorylation and eotaxin production were mediated by SOCS-1 induced in STAT1 dependent manner
Huang et al., J Immunol 2005
:
IFN-gamma suppresses
STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor ... Our results suggest that
IFN-gamma may
suppress phosphorylation of
STAT6 by inhibiting its recruitment to the IL-4R
Rodriguez-Galán et al., J Immunol 2005
:
The IL-2-plus-IL-18 or IL-12-plus-IL-18 effect on
IFN-gamma and IL-13 expression is dependent on Stat4 and NF-kappaB but
independent of
Stat6 , T-bet, or NFAT
Suto et al., J Immunol 2005
:
These results indicate that PDCs preferentially produce
IFN-gamma upon IL-4
stimulation by
Stat6- and Stat4 dependent mechanisms
Morris et al., J Immunol 2006
:
IL-4 induced
Stat6 dependent
IFN-gamma production by NK and, to a lesser extent, NKT cells, but not conventional T cells, in 2-4 h. Increased IFN-gamma production persisted at a constant rate for > 24 h, but eventually declined, even with continuing IL-4 stimulation ... Thus, IL-4, acting through the type 1 IL-4R, induces
Stat6 dependent
IFN-gamma secretion by NK and NKT cells
McCusker et al., J Immunol 2007
(Acute Disease...) :
In contrast, the
STAT-6-IP did not
affect production of
IFN-gamma , demonstrating specificity for Th2 cytokine inhibition
Liu et al., J Immunol 2007
:
Activation of NF-kappaB,
STAT6 , and STAT1 was
induced in eosinophils by TNF-alpha, IL-4, and
IFN-gamma , respectively
Moynihan et al., Respir Res 2008
:
Pre-treatment with IL-4, IL-13 and, to a lesser degree,
IFN-gamma reduced peak
STAT6 phosphorylation in response to IL-13
Asonuma et al., Am J Physiol Gastrointest Liver Physiol 2009
(Helicobacter Infections...) :
Furthermore, H. pylori and
IFN-gamma inhibited the phosphorylation of
STAT6 , resulting in the suppression of IL-4 mediated Sox2 expression
Kang et al., Experimental biology and medicine (Maywood, N.J.) 2010
:
The downregulation of
IFN-gamma and IL-4 was not
mediated by its effects on signal transducer and activator of transcription ( STAT ) 4 and
STAT6 activation
Guo et al., J Clin Invest 1997
:
IFNgamma and IL-4 stimulation
activated STAT1 and
STAT6 in HAEC, but conditioned media transfer to HAEC produced even higher levels of STAT1 activation than achieved by direct addition of cytokines
Ohmori et al., J Immunol 1997
:
Rather,
IFN-gamma and IL-4 independently
activate STAT1 and
STAT6 , respectively, and both proteins bind to the IRF-1 SBE in homodimeric form
Ohmori et al., J Biol Chem 1998
(Inflammation) :
IFNgamma and IL-4
activated STAT1 and
STAT6 , respectively, and both proteins were able to bind the gammaRE motif