Gene interactions and pathways from curated databases and text-mining

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IL2 — STK39

Text-mined interactions from Literome

Maslinski et al., J Biol Chem 1992 : Stimulation of the interleukin-2 (IL-2) receptor results in phosphorylation and activation of cytosolic Raf-1 serine/threonine kinase
Valentine et al., Eur J Immunol 1991 : The differences in the phosphorylation patterns induced by IL2 and PMA further suggest that more than one kinase can use CD45 as substrate and that IL2 activates a protein serine/threonine kinase different from protein kinase C
Amato et al., J Mol Med (Berl) 2009 : Serum and glucocorticoid regulated kinase 1 ( Sgk1 ) is a serine-threonine kinase that is activated by serum, steroids, insulin, vasopressin, and interleukin 2 at the transcriptional and post-translational levels
Goldstein et al., J Immunol 1993 : Taken together, our data demonstrate that activation of both a serine/threonine kinase and a tyrosine kinase is involved in the IL-2 , IL-4, and IL-6-stimulation of IgM secretion by SKW6.4 cells and activation of the same or a similar serine/threonine protein kinase is an early step in the signal transduction pathway used by these cytokines