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PCNA — TGFB1

Text-mined interactions from Literome

Choi et al., J Biol Chem 1999 (Liver Neoplasms, Experimental) : TGF-beta1 induced a transient increase in the expression of Cdc2, cyclin A, cyclin B, and cyclin D1 at an early phase of apoptosis
Wolf et al., Kidney Int Suppl 2000 (Diabetic Nephropathies) : High glucose, transforming growth factor-beta ( TGF-beta ), angiotensin II, and probably other factors induce inhibitors of cyclin dependent kinases (CDK) including p21Cip1 and p27KiP1
Hashimoto et al., Pancreas 2001 (Carcinoma, Pancreatic Ductal...) : p21 ( WAF1/CIP1 ), one of the cyclin dependent kinase (Cdk) inhibitors induced by TGF-beta1 , is considered a downstream effector of the growth-inhibitory function of TGF-beta1
Roy et al., Circ Res 2003 (Hyperoxia) : The molecular signature response to perceived hyperoxia included ( 1 ) induction of p21, cyclin D1, cyclin D2, cyclin G1, Fos related antigen-2, and transforming growth factor-beta1, ( 2 ) lowered telomerase activity, and ( 3 ) activation of transforming growth factor-beta1 and p38 mitogen activated protein kinase
Gong et al., Cancer Res 2003 (Adenocarcinoma...) : TGF-beta 1 inhibited DNA synthesis and cyclin dependent kinase (CDK) activity after release from growth arrest in association with induction of the p21 CDK inhibitor, whereas cyclins, CDKs, and p27 protein levels remained relatively unchanged
Zhou et al., Endocrinology 2003 : An inhibitor of cyclin dependent kinase (cdk) , p15INK4b, was up-regulated at both transcript and protein levels in these cultures by TGF-beta1 in a dose related manner as determined by RT-PCR and Western blot analysis
Shi et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2004 : ( 2 ) 2 ng/ml TGF-beta1 could significantly inhibit the production of cyclin A, cyclin D1, CDK2 and CDK4, the protein levels were significantly lower than control group
Gonzalez et al., J Reprod Dev 2010 (Hyperplasia...) : The in vitro effect of TGF-beta1 ( 1 ng/ml ) plus progesterone ( 10 ( -6 ) M ) on purified Leydig cells from 3 week-old mice increased the immunocytochemically detected PCNA and stimulated the phosphorylation of Smad 1/5
Yu et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010 : The TGF-beta1 ( 5 ng/ml ) induced arrest of cells in G1 phase ( p < 0.05 ) compared with As2O3 alone and As2O3 combined with TGF-ß1, while there was no difference with control. P27 ( Kip1 ) expression was up regulated ( p < 0.05 ), cyclin E and BCL-2 expression was down-regulated ( p < 0.05 ) in TGFß1 treated group. BCl-2 expression was down regulated, endogenesis TGFß1 expression was up regulated ( p < 0.05 ), and the level of P27 ( kip1 ) and cyclin E were not changed in As2O3 treated group ( p > 0.05 )
Stieger et al., Diabetes Metab Res Rev 2011 (Diabetes Mellitus, Type 1...) : Common pathway components induced by high glucose and advanced glycation end-products are reactive oxygen species, cyclin dependent kinases ( p27 ( Kip1 ) ) and transforming growth factor-beta
Barlat et al., Oncogene 1995 : TGF-beta 1 and cAMP attenuate cyclin A gene transcription via a cAMP responsive element through independent pathways
Oberhammer et al., Carcinogenesis 1995 : As demonstrated by immunohistochemical detection of PCNA, TGF-beta 1 prevented induction of PCNA by epidermal growth factor (EGF)
Ko et al., Oncogene 1995 : Cyclin D3 levels were not affected by TGF-beta 1 during G1 traverse
Rao et al., J Biol Chem 1995 : Positive and negative regulation of D-type cyclin expression in skeletal myoblasts by basic fibroblast growth factor and transforming growth factor beta
Schoecklmann et al., Kidney Int 1997 : Moreover, TGF-beta1 significantly reduced cyclin E-associated histone H1 kinase activity in the presence of PDGF
Yoshizumi et al., J Biol Chem 1997 : The TGF-beta1 induced down-regulation of cyclin A promoter activity appeared to be mediated via the activating transcription factor (ATF) site, because mutation of this site abolished down-regulation ... TGF-beta1 induced down-regulation of cyclin A promoter activity was reversed by okadaic acid ( a phosphatase inhibitor ) and by cotransfection with plasmids expressing the cAMP dependent protein kinase catalytic subunit or the simian virus small tumor antigen ( Sm-t, an inhibitor of PP2A )
Quesnel et al., Blood 1998 (Myelodysplastic Syndromes) : p15(INK4b) gene is an inhibitor of cyclin dependent kinase (CDK) 4 and CDK6 whose expression is induced by transforming growth factor ( TGF ) beta