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IGF1 — TMED7

Text-mined interactions from Literome

Dupont et al., Mol Pathol 2001 (Breast Neoplasms) : Whereas IGF-1 increases p21 expression and reduces p27 expression, oestradiol has no effect on p21
Lu et al., Int J Cancer 2004 (Breast Neoplasms) : We also found that the decrease in p27 ( Kip1 ) induced by IGF-I was accompanied by an increase in expression of Skp2, which is a ubiquitin ligase for p27 ( Kip1 ), and by increased Skp2 association with p27 ( Kip1 ) ... Finally, specific inhibitors of MAPK and PI3K suggest that the IGF-I mediated reduction in p27 ( Kip1 ) protein level by increased degradation predominantly involves the PI3K pathway