Gene interactions and pathways from curated databases and text-mining

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MTOR — TNF

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Baker et al., Mol Immunol 2009 : Pharmacologic inhibition of mTOR with rapamycin inhibited LPS induction of IL-10 mRNA and protein, and enhanced the expression of TF and the proinflammatory cytokine TNFalpha in WT PMs
Li et al., J Immunol 2011 (HIV Infections...) : Furthermore, mTOR inhibition augmented LA-induced TNF-a release through enhanced and prolonged phosphorylation of ERK1/2 and JNK1/2 MAPK, which was associated with time dependent MKP-1 destabilization ... Targeted gene silencing of MyD88 ( short hairpin RNA ) and mTOR ( RNA interference ) inhibition resulted in TLR-4 mediated 70-kDa ribosomal protein S6 kinase activation and enhanced TNF-a release, whereas IL-10 release was inhibited in both silenced and nonsilenced HIV ( + ) macrophages
Yarosh et al., Photodermatol Photoimmunol Photomed 2000 : However, UV-B also induced expression of membrane bound TNFalpha , and this was dependent on FRAP signaling
Zhang et al., Basic Res Cardiol 2012 (Calcium Signaling...) : The aim of this study was to investigate the role of Na/K-ATPase/mTOR signaling in myocardial TNF-a expression during endotoxemia
Gao et al., J Biol Chem 2003 (Insulin Resistance) : Phosphorylation of Akt and the mammalian target of rapamycin ( but not extracellular regulated kinase or PKCzeta ) in response to TNF-alpha was inhibited by aspirin treatment
Spentzas et al., International journal of inflammation 2012 : These findings suggest that NMDA induced TNF suppression can be augmented by concurrent mTOR inhibition
Rosner et al., Mutat Res 2008 (Alzheimer Disease...) : Recently, it has been recognized that mTOR is regulated by TNF-alpha and Wnt, both of which have been shown to play critical roles in the development of many human neoplasias
Dan et al., J Immunol 2008 : In this study, we have explored the involvement of both IKKalpha and IKKbeta in insulin- and TNF induced mTOR activation ... In MCF7 cells, TNF does not activate Akt and requires IKKbeta to activate mTOR
Tsou et al., J Cell Biochem 2010 : TNF-alpha also increased the Akt and mTOR phosphorylation