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AKT1 — TSC22D3

Text-mined interactions from Literome

Grugan et al., J Steroid Biochem Mol Biol 2008 (Multiple Myeloma) : Addition of interleukin-6 (IL-6) or insulin-like growth factor ( IGF1 ), both which activate the PI3-kinase/AKT pathway and inhibit GC killing, blocked up regulation of GILZ by GC and PI3-kinase/AKT inhibitors ... In summary, these results identify GILZ as a mediator of GC killing, indicate a role of PI3-kinase/AKT in controlling GILZ regulation and suggest that the combination of PI3-kinase/AKT inhibitors and GCs may be a beneficial MM treatment
Redjimi et al., Molecular cancer 2009 (Ovarian Neoplasms) : To assess the effect of GILZ on proliferation and AKT activation, we used the BG-1 cell line derived from ovarian tumor cells as a cellular model ... We found that GILZ increased cell proliferation, phospho-AKT cellular content and AKT kinase activity ... Our findings clearly indicate that GILZ activates AKT , a crucial signaling molecule in tumorigenesis