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MAPK1 — UTP18
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Huwiler et al., Br J Pharmacol 2000
:
3. Time courses reveal that ATP and
UTP induce a rapid and transient activation of the
p38-MAPK activity with a maximal activation after 5 min of stimulation which declined to control levels over the next 20 min. 4
Tu et al., Br J Pharmacol 2000
(Glioma...) :
3. In
response to
UTP , both p42 and p44
MAPK were activated in a time- and concentration dependent manner using Western blot analysis with an anti-phospho-p42/p44 MAPK antibody ... Both DNA synthesis and phosphorylation of
MAPK in
response to
UTP were attenuated by tyrosine kinase inhibitors, genistein and herbimycin A, protein kinase C ( PKC ) inhibitors, staurosporine and GF109203X, and removal of Ca ( 2+ ) by addition of BAPTA/AM plus EGTA ... 5.
UTP induced [ ( 3 ) H ] -thymidine incorporation and p42/p44
MAPK phosphorylation was completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) ... Furthermore, we showed that overexpression of dominant negative mutants of Ras ( RasN17 ) and Raf ( Raf-301 ) completely suppressed MEK1/2 and p42/p44
MAPK activation
induced by ATP and
UTP ...
UTP mediated
MAPK activation was modulated by Ca ( 2+ ), PKC, and tyrosine kinase associated with cell proliferation in cultured C ( 6 ) glioma cells
Meshki et al., Am J Physiol Cell Physiol 2004
:
ATP and
UTP caused activation of p38
MAPK and ERK1/2 in human neutrophils
Montiel et al., Cell Physiol Biochem 2006
:
ATP, 2-meSATP,
UTP and UDP
cause a rapid and transitory increase in the phosphorylation of
MAPK/ERK
Chang et al., Cell Signal 2008
(MAP Kinase Signaling System) :
UTP and ATP
activated MAPK in a dose- and time dependent manner
Vázquez-Cuevas et al., Reproductive biology and endocrinology : RB&E 2010
(MAP Kinase Signaling System) :
It was found that
UTP increased
MAPK phosphorylation by up to 550 % with an EC50 of 3.34 +/- 0.92 and 1.41 +/- 0.67 microM, for p44 and p42, respectively ; these increases were blocked by suramin
Huwiler et al., Br J Pharmacol 1994
:
Activation of
mitogen activated protein kinase by both ATP and
UTP is dose-dependently attenuated by the P2-receptor antagonist, suramin
Graham et al., Biochem J 1996
:
We have investigated the mechanisms that bring about the termination of
mitogen activated protein kinase ( MAP kinase ) activation in
response to
UTP in EAhy 926 endothelial cells
Graham et al., Br J Pharmacol 1996
:
Stimulation by the nucleotides, ATP and
UTP of
mitogen activated protein kinase in EAhy 926 endothelial cells
King et al., Neuroscience 1996
:
UTP and 2-methylthioATP
stimulated mitogen activated protein kinase to the same extent as ATP, although UTP was less potent than either ATP or 2-methylthioATP
Patel et al., Biochem J 1996
:
2-Methylthio-ATP and
UTP , selectively activating P2Y1 and P2Y2 purinoceptors respectively, and ATP, a non-selective agonist at these two receptors,
stimulate the tyrosine phosphorylation of both
p42mapk and p44mapk, as revealed by Western blots with an antiserum specific for the tyrosine phosphorylated forms of the enzymes