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ABCA1 — IL10
Text-mined interactions from Literome
Rubic et al., Cardiovasc Res 2006
(Atherosclerosis) :
Experiments with inhibitors, LXRalpha silencing and the LXRE reporter gene construct supported the proximal transmission of the
IL-10 effect on
ABCA1 by the IL-10 receptor/signal transducer and activator of transcription 3 ( STAT3 ) pathway and distal cross-talk to the LXRalpha and PPARalpha/retinoic acid X receptor (RXR) and cAMP/protein kinase A (PKA) pathways
Mei et al., Cell Biol Int 2007
:
This study investigates the
effects of tumour necrosis factor-alpha (TNF-alpha) and
interleukin-10 (IL-10) on
ABCA1 expression and cholesterol content in THP-1 macrophage derived foam cells ... In addition
IL-10 time-dependently decreased cholesterol accumulation by up-regulating ABCA1 expression and
inhibited the down-regulation of
ABCA1 by TNF-alpha in THP-1 macrophage derived foam cells, which may be one of the mechanisms of IL-10 contributing to its anti-atherosclerotic action